I would like to introduce some papers related to SyncroPatch.
A modern automated patch-clamp approach for high throughput electrophysiology recordings in native cardiomyocytes
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basic information
Designed to seamlessly integrate fully automated compound screening into the drug discovery process, it provides the highest performance in high-throughput screening of ion channels within the drug discovery, pharmacology, safety, pharmaceutical research and development, and exploratory screening departments. Additionally, by utilizing the 32-well mode, it can be optimized for small-scale compound screening and projects. ■ Simultaneous measurement of 384 cells ■ 20,000 data points per day ■ High giga-seal success rate ■ Supports diverse ion channel targets and enables rapid assay system development ■ Measurement of action potentials via current clamp is also possible ■ Extracellular/intracellular perfusion possible ■ High-speed external solution exchange (up to 110 µl/s) ■ Individual temperature control for the measurement section and 12 decks (temperature range: 10–37°C) ■ Compound plate preparation on the deck ■ Use of single & multi-well chips (in-house manufactured) ■ Borosilicate glass chips reduce compound adsorption ■ Approximately 8 hours of unmanned operation possible ■ Comes with powerful analysis software ■ Validated system for CiPA
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Applications/Examples of results
For more details, please refer to the PDF document or feel free to contact us. For inquiries about products, requests for demos, requests for catalogs, or any other inquiries, please feel free to contact us directly. Mail: info@nanion.jp
catalog（10）
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![[Measurement Example] ASIC3 | SyncroPatch 384PE](https://image.mono.ipros.com/public/catalog/image/01/55e/743610/IPROS92495899848528606941.jpeg?w=120&h=170)
![[Measurement Example] Nav1.5 | SyncroPatch 384i](https://image.mono.ipros.com/public/catalog/image/01/d26/743620/IPROS50860186923086299028.jpeg?w=120&h=170)
![[Measurement Example] HCN2 | SyncroPatch 384i](https://image.mono.ipros.com/public/catalog/image/01/d58/743624/IPROS78444219912437324393.jpeg?w=120&h=170)
![[Measurement Example] DRG Neurons | SyncroPatch 384](https://image.mono.ipros.com/public/catalog/image/01/47b/778787/IPROS65289700910919774271.jpeg?w=120&h=170)
![[Measurement Example] P2X3 and P2X2/3 Receptors | SyncroPatch 384](https://image.mono.ipros.com/public/catalog/image/01/7d0/778795/IPROS52295252045178902973.jpeg?w=120&h=170)
![[Measurement Example] TMEM175 | SyncroPatch 384](https://image.mono.ipros.com/public/catalog/image/01/564/778801/IPROS63641714250739935882.jpeg?w=120&h=170)
![[Measurement Example] TRP Channels | SyncroPatch 384](https://image.mono.ipros.com/public/catalog/image/01/a33/778807/IPROS02014275612822051712.jpeg?w=120&h=170)
Company information
Nanion Technologies is a scientific instrument manufacturer founded in 2002 in Munich, Germany, specializing in the automation of electrophysiology experiments. We enable the automation of electrophysiology experiments, supporting not only ion channel research but also a wide range of membrane protein-related studies. We offer a broad product lineup, including our industry-leading automated patch clamp system, transporter activity measurement systems, artificial lipid bilayer experimental devices, liposome production devices, and impedance, extracellular potential, and contraction force measurement systems for iPS-derived cardiomyocytes. These systems have been adopted by many universities, pharmaceutical companies, and research institutions both domestically and internationally, and are highly regarded. For inquiries about our products, requests for introductions, demo requests, or catalog requests, please contact us or our authorized distributors. Additionally, feel free to consult us about visiting our Tokyo lab (Meguro Ward) to see the systems and experiments. Mail: info@nanion.jp