Improving SEC analysis of proteins, in addition to lipid nanoparticles (LNP), nucleic acids, and viral vectors.
The Waters GTxResolve Premier SEC column enables superior and faster separations by minimizing particle size to the extreme. Additionally, the new HO-PEO bonding reduces both ionic and hydrophobic adsorption, and the stable bonding also achieves noise reduction in MALS. The column tube is treated with MaxPeak technology, eliminating concerns about metal adsorption. 【Features】 - High separation capability allows for the detection of low-concentration impurities, accelerating the analysis of aggregates and size variants. - Provides reproducible data with minimal lot-to-lot and column-to-column variation. - Cost reduction through extended column lifespan. - Reduces secondary interactions and decreases noise in multi-angle light scattering detectors (MALS). - Utilizes low-adsorption hardware necessary for improving the recovery rate of biopharmaceuticals.
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basic information
This is an LC column that can be used for size exclusion chromatography (SEC) of mRNA, LNP, viral vectors, and protein pharmaceuticals.
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Applications/Examples of results
Analysis of aggregates/size variants of active pharmaceutical ingredients and formulations for gene therapy Evaluation of aggregate content, integrity, heterogeneity, and purity
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Company information
Waters Corporation, headquartered in Milford, Massachusetts, USA, has played a pioneering role as a specialized manufacturer of liquid chromatography since its establishment in 1958. Actively engaged in the development of new products and technologies, it has grown into an international group company that supplies not only high-performance liquid chromatography but also mass spectrometers (MS) and thermal analysis instruments. Waters Japan started operations in 1973 (Showa 48) as the Japanese base of Waters Corporation. Inheriting the corporate ethos of the U.S. headquarters, we have made "Customer Success" our mission and continue to provide innovative technologies and lab solutions.