Fluorescent staining of lipid bilayers without false positives
Cutting-edge visualization using fluorescent staining The characteristics of Acoerela dye are its high quantum yield (>25%) and specificity. A significant increase in fluorescence intensity is observed only when the fluorescent dye binds to the target, during which the hydrophobicity of the environment surrounding the dye changes. The substantial difference in emission profiles between bound and unbound dyes underlies the "light-on" mechanism.
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■Water-soluble dye Acoerela dye is highly water-soluble and does not cause false positives that have been problematic in flow cytometry analysis of extracellular vesicles. Unlike the PKH26, DiR, and DiD dye families, it does not form micelles or nanoparticles when reconstituted in aqueous buffers.
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Applications/Examples of results
■High-precision tracking of extracellular vesicles using Aco-490: New possibilities for RBCEV ■Optimal dyes for staining extracellular vesicles ■Dyes for animal cell membranes ■NIR-II tumor tracking dye ■Gram-selective dyes for bacteria
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Our researcher customers are dedicated to their research day and night to "change the world" and "create the future." The products we handle reach the hands of researchers, contributing to the advancement of science and technology in Japan. Our company plays a role in creating such an exciting future and has been supporting researchers in the niche fields of environment, materials, and biotechnology as a top partner for 50 years since our establishment.