[Workshop Announcement] "New Technologies for EV, LNP, and Gene Introduction 2025: A Workshop to See, Touch, and Listen"

An innovative solution that enables analysis at the single particle level: Nano FCM Flare & Auto20 now available.

Innovative solution for analysis at the single particle level ★NanoFCM Flare★ 　Measurement of biological particles from 40nm 　For the production and evaluation of EVs, viruses, nucleic acid drugs, etc. ★NanoFCM Auto20★ High-throughput model equipped with auto-sampling and cleaning functions ■Capable of fluorescent detection of single molecules, phenotypes are quantified from marker intensity ■High-resolution size distribution comparable to TEM ■Measures the number concentration of all particles and fluorescently labeled particles ■Quantifies particle populations with up to two fluorescent labels

• Other physicochemical equipment
• Particle Counter
• Analytical Equipment and Devices

Exoid (TRPS) enables accurate and reliable zeta potential measurements compared to other methods.

Exoid (TRPS) enables accurate and reliable zeta potential measurements compared to other methods. 【Features】 ■ Simultaneous measurement of zeta potential and particle size for each particle ■ Unbiased results obtained through true zeta potential distribution ■ Measurement of charge at physiological strength in buffer ■ Measurement principle is the electrical resistance nanopulse method (TRPS) ■ Measurement of changes in surface charge *For more details, please refer to the materials or feel free to contact us.

• Other measurement, recording and measuring instruments

Extract high-purity extracellular vesicle extracts! Automatic recovery devices for extraction and cleaning are also available!

The "qEV Series" is an exosome extraction kit that can extract highly pure extracellular vesicle extracts. The "qEV Extracellular Vesicle Extraction Kit" has obtained the international standard for quality management of medical devices, ISO 13485. It allows for the separation and purification of exosomes and extracellular vesicles in just 15 minutes. The "AFC qEV Column Automatic Recovery Device" automates the process from extraction to cleaning, making the extraction of EVs much easier. 【Features】 ■ Kits can be selected based on research purposes and sample volume. ■ High-efficiency and high-precision analysis can be achieved when used with qNano. ■ Separation can be performed while maintaining the biological and morphological characteristics of EVs. ■ Improved sensitivity and accuracy for analysis and measurement. ■ Obtained the international standard for quality management of medical devices, ISO 13485. *For more details, please refer to the PDF materials or feel free to contact us.

• Separation device
• Other physicochemical equipment
• Analytical Equipment and Devices

Extraction to cleaning, making the work easier automatically!

The "AFC" is an automatic recovery device for qEV columns that simplifies the extraction process of extracellular vesicles (EVs) from extraction to cleaning. By automatically recovering fractions based on weight detection, it minimizes variability due to manual work, achieving greater reproducibility than ever before. Additionally, it features an RFID tag (an IC tag that can store information) to manage manufacturing and QA data, usage counts, and cleaning cycles. When used in conjunction with the qEV series "Extracellular Vesicle Extraction Kit" and the nanoparticle multi-analyzer "Exoid," it enables high recovery of extracellular vesicle extraction. 【Features】 ■ Fully automated extraction to cleaning, making EV extraction work easier ■ Automatic recovery of fractions based on weight detection, minimizing variability due to manual work ■ Achieves greater reproducibility than ever before * Please use qEV and AFC for basic research purposes only. They cannot be used for clinical or medical procedures. * For more details, please refer to the PDF materials or feel free to contact us.

• Separation device
• Other physicochemical equipment
• Analytical Equipment and Devices

Improvement of each step in the extracellular vesicle (EV) research workflow.

In EV research, accurate and efficient separation from biological samples is essential. Characterization and quantification of EVs are performed to confirm purity and consistency. Subsequently, biological activity is assessed through functional assays, and the potential for therapy is explored. Innovative products play a crucial role in this complex process.

• Staining Reagents

Fluorescent staining of lipid bilayers without false positives

Cutting-edge visualization using fluorescent staining The characteristics of Acoerela dye are its high quantum yield (>25%) and specificity. A significant increase in fluorescence intensity is observed only when the fluorescent dye binds to the target, during which the hydrophobicity of the environment surrounding the dye changes. The substantial difference in emission profiles between bound and unbound dyes underlies the "light-on" mechanism.

• Staining Reagents

Cell-friendly gene introduction: Next-generation transfection platform

Using the latest photoporation technology, a wide variety of cells, including iPS cells and CAR-T cells, can be introduced with various substances such as nucleic acids, proteins, and CRISPR/Cas9 RNPs. This method provides minimal damage during introduction, high survival rates, and achieves efficient transfection with high throughput. Photoporation is a gentle method for delivering payloads to cells based on the interaction between pulsed laser light and photothermal nanosenstizers. When laser light is applied to unique nanosenstizers adjacent to the cells, temporary pores are formed in the cell membrane through localized plasmonic reactions, allowing external payloads to enter the cytoplasm with minimal impact on cell survival and function. This technology serves as a next-generation transfection platform that efficiently, flexibly, and safely delivers various payloads to a wide range of cells, including primary cells, where transfection is challenging.

• Genetic Analysis Software

Cancer Biomarker Discovery 2026 is an online seminar focused on the latest biomarker discovery and analysis technologies in the field of cancer research. Advanced technologies that support the understanding, diagnosis, and treatment research of cancer, such as liquid biopsy, proteomics, and spatial omics analysis, will be introduced. This seminar primarily targets basic and clinical researchers involved in cancer research, as well as those interested in biomarker discovery and analysis. In our section, we will introduce the latest techniques in fluorescent imaging for spatial biology and spatial proteomics research, centered around the Invitrogen EVOS S1000 Spatial Imaging System. Unlike traditional microscopy, which is limited in multiplex immunostaining, our spectral unmixing technology enables simultaneous imaging of up to 9 colors, allowing for rapid data acquisition with minimized sample damage. Additionally, we will explain a practical workflow using direct conjugate antibodies and TSA-based Invitrogen Aluora amplification reagents, proposing high-reproducibility analysis methods that leverage spatial information. For research use only. Not for diagnostic use.

In spatial biology/spatial proteomics research, the coexistence of "high-quality multiplex fluorescence image acquisition" and "reliable quantitative analysis" is becoming increasingly important. This webinar, co-hosted by Thermo Fisher Scientific and Indica Labs, will introduce a practical workflow that allows for a comprehensive understanding from imaging to analysis. Recommended for: - Those interested in spatial biology/spatial proteomics research who want to systematically understand the entire process from imaging to analysis. - Those who are already conducting or considering the implementation of multiplex imaging (multiplex immunostaining). - Those who feel limited by traditional four-color fluorescence observation and wish to engage in higher-dimensional spatial information analysis. This is a free seminar, so please join us. *For research use only. Not for diagnostic use.

[Speaker] Shinya Okimoto, Founder & CEO of Okiwa Studio LLC [Lecture Topics] Part 1: The tectonic shifts in the display industry and the market potential of QDEL Part 2: Business solutions to the "three major technical challenges" for the practical application of QDEL Part 3: Winning strategies for Japanese companies: Targeting the "high value-added components" sector Part 4: Redefining the business portfolio towards 2030 Part 5: Q&A

[Lecturer] Mr. Kenji Kimura, Chief Researcher, Nuclear Group, Power Unit, Japan Energy Economics Research Institute (JEA), and Research Strategy Group, Research Strategy Unit [Key Lecture Content] In recent years, the role of nuclear power has been highlighted in the context of global warming countermeasures and energy security, and more recently, in response to the increased electricity demand due to the use of AI and the expansion of data centers. Under these circumstances, new movements are being observed in countries that utilize nuclear power. In the United States, investments in nuclear power by IT companies are becoming more active, while in Europe, measures are being promoted to enhance the feasibility of new projects. In Japan, the role of nuclear power has been clarified once again, and discussions surrounding specific institutional measures are gradually progressing. This lecture will provide an overview of these movements and organize the trends that should be noted in the future. [Lecture Items] 1. Global Situation and Nuclear Power 2. Trends in Other Countries 3. Trends in New Reactor Development 4. Domestic Trends and Challenges 5. Key Points to Watch After 2026 6. Q&A / Business Card Exchange

At our booth, we will mainly showcase the following products: 〇 Our original product T-Arm 〇 Tecnospiro's product Spider 〇 Knight Global's product Air Balancer 〇 A drone for equipment inspections ▽------------------------------------------------------------▽ From April 8 (Wednesday) to April 10 (Friday) at Port Messe Nagoya ■ Manufacturing World Nagoya (Booth Number: 16-40) https://www.manufacturing-world.jp/nagoya/ja-jp.html ■ Pre-registration for attendance is convenient! https://www.manufacturing-world.jp/nagoya/ja-jp/register.html?code=1603005193330205-52G △------------------------------------------------------------△ We look forward to your visit.