[Exhibition Information] 25th Annual Meeting of the Japanese Society for Protein Science

Easily measure channel activity at the molecular level.

【Measurement Target Examples】 Ion channels (voltage-dependent, ligand-dependent, temperature-sensitive), DNA nanopores, antimicrobial peptides, toxins, etc. In experiments using artificial lipid bilayers, the formation of lipid membranes, reconstitution of membrane proteins, and measurement of single-channel currents can be easily performed. Purified target membrane proteins (such as ion channels in vivo or artificial ion channels) can be reconstituted on artificially formed lipid bilayers, allowing for the evaluation of drug effects and functional/structural analysis. ■ Simultaneous formation and measurement of 4 channels of artificial lipid bilayers is possible ■ Lipid membranes can be formed with just pipetting operations ■ No need for microscope, vibration isolation table, manipulator, or Faraday cage ■ Direct reconstitution of target membrane proteins or membrane fusion with proteoliposomes ■ Temperature control (10–50°C) available (optional) ■ Palm-sized, easy connection via USB

• Other physicochemical equipment
• Analytical Equipment

Easily measure channel activity at the molecular level.

【Measurement Target Examples】 Ion channels (voltage-dependent, ligand-dependent, temperature-sensitive), DNA nanopores, antimicrobial peptides, toxins, etc. Experiments using artificial lipid bilayers allow for easy formation of lipid membranes, reconstitution of membrane proteins, and measurement of single-channel currents. It is possible to reconstitute purified target membrane proteins (such as ion channels found in vivo or artificial ion channels) on artificially formed lipid bilayers for drug action evaluation and functional/structural analysis. By rapidly and automatically forming 16-channel artificial lipid bilayers at once and conducting fully simultaneous measurements, researchers are freed from the burdens of the painting method in experiments using artificial lipid bilayers. ■ Simultaneous formation and measurement of 16-channel artificial lipid bilayers is possible ■ Automatic lipid membrane formation using a stirrer bar ■ No need for microscope, vibration isolation table, manipulator, or Faraday cage ■ Direct reconstitution of target membrane proteins or membrane fusion with proteoliposomes ■ Temperature control available (10–50°C)

• Other physicochemical equipment
• Analytical Equipment

Direct measurement of transporter currents in a label-free and real-time manner without using fluorescent probes or radiolabeled ligands.

Currently, the mainstream method for evaluating transporter activity is the uptake assay using RI-labeled substrates. However, there are several issues, such as the need for specialized experimental facilities, the complexity of waste liquid treatment, the fact that the desired substrates are not always commercially available as RI-labeled, and the measurement of endpoints after uptake. SURFE²R (Surface Electrogenic Event Reader) technology does not require RI labeling, specialized experimental facilities, or waste liquid treatment, and it allows for real-time evaluation of the activity of transporters (symporters, exchangers, unipoters) and pumps. ■ Direct measurement of transporter currents using Solid Supported Membrane (SSM) ■ Experiments can be conducted using membrane fragments prepared from biological membranes or proteoliposomes reconstituted with the target membrane proteins ■ Light stimulation is possible (optional) ■ An all-in-one device that integrates a dispensing machine, measurement section, and computer ■ 150 data points per day

• Other physicochemical equipment
• Analytical Equipment
• Other Analysis

Direct measurement of transporter currents in a label-free and real-time manner without using fluorescent probes or radiolabeled ligands.

Currently, the mainstream method for evaluating transporter activity is the uptake assay using RI-labeled substrates. However, there are several issues, such as the need for specialized experimental facilities, complicated waste disposal processes, the fact that the desired substrates are not always commercially available as RI-labeled, and that the endpoint is measured after uptake. The SURFE²R (Surface Electrogenic Event Reader) technology does not require RI labeling, does not need specialized experimental facilities or waste disposal, and allows for real-time evaluation of the activity of transporters (symporters, exchangers, unipoters) and pumps. ■ Direct measurement of transporter currents using Solid Supported Membrane (SSM) ■ Experiments can be conducted using membrane fragments prepared from biological membranes or proteoliposomes reconstituted with the target membrane proteins ■ Simultaneous measurement in 96 wells ■ 10,000 data points per day

• Other physicochemical equipment
• Analytical Equipment
• Other Analysis

A patch clamp system that incorporates a patch clamp amplifier, achieving miniaturization and reduction of installation costs, allowing for easy data acquisition and verification.

This is a world-class patch clamp system capable of performing gigaseal recordings, optimal for safety testing/toxicity testing/pharmacological testing/screening of compounds at the cellular level in the functional structural analysis of ion channels, research on related diseases, and drug development processes. ■ No experience with manual patch clamping or difficult operations required ■ No need for microscope/vibration isolation table/manipulator/Faraday cage/puller ■ 20 to 50 data points per day ■ Automation from gigaseal formation to whole cell formation ■ Compatible with voltage-dependent and ligand-dependent channels through pipetting ■ Measurement of action potentials using current clamp is also possible ■ Supports a wide range of applications, enabling rapid assay system development ■ Reduces compound adsorption with borosilicate glass chips

• Other physicochemical equipment
• Analytical Equipment
• Patch clamp system

Our company will be exhibiting at the "JECA FAIR 2026 - 74th Electrical Construction Industry Exhibition" held at Tokyo Big Sight from May 27 (Wednesday) to May 29 (Friday), 2026. At this exhibition, we will introduce products such as the coreless current sensor (for reference), the "PAL-Plus typeE / PAL-Plus typeE2" suitable for simple electric power measurement in factories and facilities, and the management software "CEW-M4" that visualizes and manages power consumption and surplus capacity of equipment. 【Main Exhibited Products】 - Wire-wound coreless current sensor (for reference) - PAL-Plus typeE / PAL-Plus typeE2 - CEW-M4 Please take a look at our solutions that are easy to implement even in confined spaces or where power outage work is to be avoided, and that help solve on-site challenges. We sincerely look forward to your visit.

Dear Sir or Madam, We hope this message finds you well and that your company continues to prosper. FUKUDA will be exhibiting at the 28th INTERPHEX Week Tokyo. At the exhibition, we will be showcasing 100% inspection equipment compliant with Container Closure Integrity Testing (CCIT) standards, as well as sampling inspection machines. We sincerely invite you to visit our booth at this opportunity and would greatly appreciate your attendance despite your busy schedule. Yours sincerely, [Dates] May 20 (Wed) - 22 (Fri), 2026 10:00-17:00 (JST) [Venue] Makuhari Messe, Japan 8 Hall Booth No. 41 - 36

Date: October 16 (Wednesday) to 18 (Friday), 2024, 10:00 AM to 5:00 PM Admission Fee: 1,000 yen (free admission with pre-registration) Location: Marine Messe Fukuoka, Hall A and Hall B Exhibit Booth Number: AS-41 Details: https://www.nikkanseibu-eve.com/mono/

Dear Sir or Madam, We hope this message finds you well and that your company continues to prosper. FUKUDA will be exhibiting at the AUTOMOTIVE ENGINEERING EXPOSITION 2026 YOKOHAMA. At this exhibition, we will be showcasing testing equipment such as Air Leak Tester for EV and Equipment Mounted Type Hydrogen Leak Detector. We sincerely hope you will take this opportunity to visit us. Yours sincerely, [Official Site] https://aee.expo-info.jsae.or.jp/en/yokohama/ [DATES] Wednesday, May 27, through Friday, May 29, 2026 10:00 a.m. - 5:00 p.m. [VENUE] PACIFICO Yokohama, Exhibition Hall, Booth No. ２７４ ※Online Exposition Website：Tuesday, May 19, through Tuesday, June 9, 2026

[Speaker] KPMG Consulting Co., Ltd. Sports Innovation Associate Partner Ryo Saki Sports Innovation Manager Yota Tsumura [Presentation Items] 1. Introduction to KPMG Consulting - Support stance and strengths in the fields of sports, urban development, and public-private partnerships 2. Understanding the Background and Current Situation Why the expansion of the sports market becomes a "business opportunity" 3. What Urban Development Centered on Sports Means Value creation starting from stadiums and arenas (sports complexes) Implementation of sports and open innovation 4. Organizing Discussion Points to Consider Participation Opportunities - Where can our business and assets be utilized? - Issues and decision-making points faced by business leaders - Learning from success and failure factors in advanced domestic and international cases - Organizing actions to start discussions from tomorrow 5. Closing - The potential of sports - The value/WILL that KPMG Consulting can provide 6. Q&A / Business Card Exchange