[Exhibition Information] 25th Annual Meeting of the Japanese Society for Protein Science

Easily measure channel activity at the molecular level.

【Measurement Target Examples】 Ion channels (voltage-dependent, ligand-dependent, temperature-sensitive), DNA nanopores, antimicrobial peptides, toxins, etc. In experiments using artificial lipid bilayers, the formation of lipid membranes, reconstitution of membrane proteins, and measurement of single-channel currents can be easily performed. Purified target membrane proteins (such as ion channels in vivo or artificial ion channels) can be reconstituted on artificially formed lipid bilayers, allowing for the evaluation of drug effects and functional/structural analysis. ■ Simultaneous formation and measurement of 4 channels of artificial lipid bilayers is possible ■ Lipid membranes can be formed with just pipetting operations ■ No need for microscope, vibration isolation table, manipulator, or Faraday cage ■ Direct reconstitution of target membrane proteins or membrane fusion with proteoliposomes ■ Temperature control (10–50°C) available (optional) ■ Palm-sized, easy connection via USB

• Other physicochemical equipment
• Analytical Equipment

Easily measure channel activity at the molecular level.

【Measurement Target Examples】 Ion channels (voltage-dependent, ligand-dependent, temperature-sensitive), DNA nanopores, antimicrobial peptides, toxins, etc. Experiments using artificial lipid bilayers allow for easy formation of lipid membranes, reconstitution of membrane proteins, and measurement of single-channel currents. It is possible to reconstitute purified target membrane proteins (such as ion channels found in vivo or artificial ion channels) on artificially formed lipid bilayers for drug action evaluation and functional/structural analysis. By rapidly and automatically forming 16-channel artificial lipid bilayers at once and conducting fully simultaneous measurements, researchers are freed from the burdens of the painting method in experiments using artificial lipid bilayers. ■ Simultaneous formation and measurement of 16-channel artificial lipid bilayers is possible ■ Automatic lipid membrane formation using a stirrer bar ■ No need for microscope, vibration isolation table, manipulator, or Faraday cage ■ Direct reconstitution of target membrane proteins or membrane fusion with proteoliposomes ■ Temperature control available (10–50°C)

• Other physicochemical equipment
• Analytical Equipment

Direct measurement of transporter currents in a label-free and real-time manner without using fluorescent probes or radiolabeled ligands.

Currently, the mainstream method for evaluating transporter activity is the uptake assay using RI-labeled substrates. However, there are several issues, such as the need for specialized experimental facilities, the complexity of waste liquid treatment, the fact that the desired substrates are not always commercially available as RI-labeled, and the measurement of endpoints after uptake. SURFE²R (Surface Electrogenic Event Reader) technology does not require RI labeling, specialized experimental facilities, or waste liquid treatment, and it allows for real-time evaluation of the activity of transporters (symporters, exchangers, unipoters) and pumps. ■ Direct measurement of transporter currents using Solid Supported Membrane (SSM) ■ Experiments can be conducted using membrane fragments prepared from biological membranes or proteoliposomes reconstituted with the target membrane proteins ■ Light stimulation is possible (optional) ■ An all-in-one device that integrates a dispensing machine, measurement section, and computer ■ 150 data points per day

• Other physicochemical equipment
• Analytical Equipment
• Other Analysis

Direct measurement of transporter currents in a label-free and real-time manner without using fluorescent probes or radiolabeled ligands.

Currently, the mainstream method for evaluating transporter activity is the uptake assay using RI-labeled substrates. However, there are several issues, such as the need for specialized experimental facilities, complicated waste disposal processes, the fact that the desired substrates are not always commercially available as RI-labeled, and that the endpoint is measured after uptake. The SURFE²R (Surface Electrogenic Event Reader) technology does not require RI labeling, does not need specialized experimental facilities or waste disposal, and allows for real-time evaluation of the activity of transporters (symporters, exchangers, unipoters) and pumps. ■ Direct measurement of transporter currents using Solid Supported Membrane (SSM) ■ Experiments can be conducted using membrane fragments prepared from biological membranes or proteoliposomes reconstituted with the target membrane proteins ■ Simultaneous measurement in 96 wells ■ 10,000 data points per day

• Other physicochemical equipment
• Analytical Equipment
• Other Analysis

A patch clamp system that incorporates a patch clamp amplifier, achieving miniaturization and reduction of installation costs, allowing for easy data acquisition and verification.

This is a world-class patch clamp system capable of performing gigaseal recordings, optimal for safety testing/toxicity testing/pharmacological testing/screening of compounds at the cellular level in the functional structural analysis of ion channels, research on related diseases, and drug development processes. ■ No experience with manual patch clamping or difficult operations required ■ No need for microscope/vibration isolation table/manipulator/Faraday cage/puller ■ 20 to 50 data points per day ■ Automation from gigaseal formation to whole cell formation ■ Compatible with voltage-dependent and ligand-dependent channels through pipetting ■ Measurement of action potentials using current clamp is also possible ■ Supports a wide range of applications, enabling rapid assay system development ■ Reduces compound adsorption with borosilicate glass chips

• Other physicochemical equipment
• Analytical Equipment
• Patch clamp system

[Speaker] Naomasa Shibuya, Department Manager Data Marketing Unit, Strategy and Platform Division East Japan Railway Company Marketing Headquarters [Key Lecture Content] East Japan Railway Company announced a new group management vision, "Yusho 2034," aimed at realizing a rich life for all people by July 2025. In addition to the railway transportation business, we will further expand lifestyle service businesses (non-railway) such as station facilities, station buildings, hotels, and real estate, promoting human-centered marketing focused on our customers. To achieve this, data marketing utilizing usage history from Suica and JRE Point members is essential. It is not enough to simply implement tools or acquire analytical techniques; it is crucial to cultivate personnel who understand the business and can conduct appropriate data analysis and strategy planning. We will also introduce the development of job-type personnel in data marketing, which we began recruiting in 2024. In this lecture, I will discuss the key points for advancing data marketing within a business company, incorporating case studies.

[Lecturers] Mitsubishi UFJ Research and Consulting Co., Ltd. Consulting Business Division Sustainability Business Unit, Sustainability Strategy Department, Group 1 Senior Manager Ryo Maeda Consultant Keiro Shimada [Key Lecture Content] Towards achieving carbon neutrality by 2050, Japan is advancing the introduction of a carbon pricing system. This lecture will explain the overview of carbon pricing and the price determination mechanisms for fossil fuel levies and specific business burdens, and will discuss future price forecasts and their impact on companies. Furthermore, it will organize the latest trends in GX-ETS Phase 2 and carbon credits, as well as issues related to credit supply and demand and utilization, and will propose measures that companies need to take in light of the introduction of the carbon pricing system. [Lecture Items] 1. Trends in the carbon pricing system 2. Trends in carbon credits 3. Required responses from companies 4. Q&A / Business card exchange

We will be exhibiting at the "International Frontier Industry Messe," one of the largest comprehensive exhibitions in western Japan. September 4 (Thursday) - 5 (Friday), 2025 Kobe International Exhibition Hall 2nd floor, Hall 1, Booth Number P-74 Inside the Aioi Chamber of Commerce booth We sincerely look forward to your visit.

In recent years, the pharmaceutical and medical industries have faced urgent challenges, including the digitization of standard operating procedures (SOPs) and the strengthening of continuous education and human resource development. In this webinar, we will introduce a comprehensive system that not only streamlines operations but also consistently supports education and human resource development by integrating Agatha's SOP management cloud solution "Agatha SOP" with "Ave-TMS," a training management system provided by BIO-TREND BIOPRODUCTS, with whom Agatha has recently signed a distribution agreement. [Program] Part 1: 14:00 - 14:20 "Introduction to Agatha Solutions" Agatha Inc. Sales & Marketing Department, Quality Group Part 2: 14:20 - 15:00 "Ave-TMS Demo Presentation" BIO-TREND BIOPRODUCTS Project Manager, Choi Woo-Chun *For Q&A, please fill out the survey displayed after the webinar, and we will respond later.

[Speaker] Toshio Kawamoto, Managing Director / Head of Cross Creation Group, NTT Data Management Research Institute, Business Transformation Unit, and Co-representative of Social Innovation Alliance Japan Denmark Takaaki Sukegawa, Senior Manager [Lecture Items] 1. Competitiveness and Governance in the Post-Generative AI Era - Toshio Kawamoto [13:00 - 14:00] 1. Introduction to NTT Data Management Research Institute 2. Major countries' perspectives on AI utilization 3. Considerations for companies when building AI governance 4. Examples of AI governance construction in Japan 5. Introduction of our company's achievements in related projects 6. Q&A / Business card exchange 2. On-Site AI Risk Management in Europe ~Introduction to Trends in AI Utilization in Europe and Advanced Centralized AI Risk Management Solutions~ - Takaaki Sukegawa [14:10 - 15:10] 1. Overview of centralized AI risk management 2. Detailed approach 3. Introduction of case studies applying the approach 4. Q&A / Business card exchange