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  6. Transporter activity measurement device SURFE²R N1

Transporter activity measurement device SURFE²R N1

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SURFE²R N1

last updated:Apr 30, 2025

ナニオンテクノロジーズジャパン 東京ラボ(東京大学内)
ナニオンテクノロジーズジャパン 東京ラボ(東京大学内)
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Direct measurement of transporter currents in a label-free and real-time manner without using fluorescent probes or radiolabeled ligands.

Currently, the mainstream method for evaluating transporter activity is the uptake assay using RI-labeled substrates. However, there are several issues, such as the need for specialized experimental facilities, the complexity of waste liquid treatment, the fact that the desired substrates are not always commercially available as RI-labeled, and the measurement of endpoints after uptake. SURFE²R (Surface Electrogenic Event Reader) technology does not require RI labeling, specialized experimental facilities, or waste liquid treatment, and it allows for real-time evaluation of the activity of transporters (symporters, exchangers, unipoters) and pumps. ■ Direct measurement of transporter currents using Solid Supported Membrane (SSM) ■ Experiments can be conducted using membrane fragments prepared from biological membranes or proteoliposomes reconstituted with the target membrane proteins ■ Light stimulation is possible (optional) ■ An all-in-one device that integrates a dispensing machine, measurement section, and computer ■ 150 data points per day

    Other physicochemical equipmentAnalytical EquipmentOther Analysis
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Transporter activity measurement device SURFE²R N1

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N1.jpg
  • Related Link - https://www.ipros.jp/news/detail/77559?hub=151+463…

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【Examples of Application Results】 Forced Expression Systems: h NaK-ATPase, h PepT1, rbSGLT1, hSGLT1-xx, m EAAC1, h NCX1-3, h NCKX1, h NIS, h PAT1, h CNT1, rOCT2, h OCT2, h GAT1, CLCs, CliC, HR, ChR, A-M2, P2X Bacteria: melB, NhaA, putP, Kdp-ATPase, BR, F0F1-ATPase, Ydgr, YhiP, CICEC, A-M2 Tissues: nAChR Torpedo, NaK-ATPase, NCX (Heart PM), HK-ATPase (Stomach PM), Ca-ATPase (ER/SR), H-ATPase, CLC (Synaptic vesicles), Complex I, II, III, IV, V, ANT, OxPhos (Mitochondria) 【Application】List of Validated Targets for SURFE²R https://www.ipros.jp/news/detail/77559?hub=151+4633609

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For more details, please refer to the PDF document or feel free to contact us. For inquiries about products, requests for demos, requests for catalogs, or any other inquiries, please feel free to contact us directly. Mail: info@nanion.jp

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Comprehensive Catalog: Electrophysiology Experimental Equipment Catalog vol. 6

Comprehensive Catalog: Electrophysiology Experimental Equipment Catalog vol. 6

CATALOG
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Transporter activity measurement device SURFE²R N1

Transporter activity measurement device SURFE²R N1

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Validated Target List: Transporter Activity Measurement Device

Validated Target List: Transporter Activity Measurement Device

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[Measurement Example] TMEM175 | SURFE²R 96SE

[Measurement Example] TMEM175 | SURFE²R 96SE

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[Workshop Announcement] Electrophysiology Experiment Workshop 2025

  • Seminar・Event

You can experience actual measurements and demonstrations using our various products. For more details about the products, please refer to the related products below. *Capacity: Approximately 10 to 20 people *Due to limited lab space, depending on the number of participants, there may be a possibility of dividing into two sessions, morning and afternoon. *Participants who register for the workshop will be contacted again once the details are finalized.

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[Seminar Announcement] Membrane Physiology Symposium Japan 2025

  • Seminar・Event

We are pleased to announce that Nanion Technologies Japan Co., Ltd. will co-host the Membrane Physiology Symposium Japan 2025 in collaboration with Professor Hideaki Kato's laboratory at the University of Tokyo's Advanced Research Center. Following the symposium, we will also hold a modest networking event, and we warmly invite you to participate. For details on the program and other information, please refer to the related PDF documents. Speakers (in alphabetical order): - Dr. Kenji Akiyoshi | Keio University, Faculty of Pharmacy - Dr. Shuutarou Katsurabayashi | Fukuoka University, Faculty of Pharmacy - Dr. Hideaki Kato | University of Tokyo, Advanced Research Center - Dr. Tomoya Kubota | Osaka University Graduate School of Medicine - Dr. Shin Hamamoto | University of Tokyo Graduate School of Agricultural and Life Sciences - Dr. Yuichiro Miyaoka | Tokyo Metropolitan Institute of Medical Science - Dr. Chai-Ann Ng | Victor Chang Cardiac Research Institute - Dr. Alexandre Santinho | Oria Bioscience - Dr. Will Seibertz | Nanion Technologies GmbH - Dr. Martin Ziller | Nanion Technologies GmbH

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[Seminar Announcement] Ion Channel Forum 2023

  • Seminar・Event

We are pleased to announce that Nanion Technologies Japan Co., Ltd. will be hosting the Ion Channel Forum 2023 in person for the first time in four years, in collaboration with Tokyo Women's Medical University. Following the forum, we will hold a modest networking event at a hotel in Tokyo. Additionally, we plan to conduct a workshop on electrophysiology using our various products the following day. Scheduled speakers (in alphabetical order): Dr. Tadashi Kimura | Veneno Technologies Co., Ltd. Dr. Takaaki Sogabe | Center for Life Creation Research, Temperature Biology Research Group Dr. Kiyoshi Takasago, Dr. Hatsue Furukawa | Axcelead Drug Discovery Partners, Inc. Dr. Takuma Takada | Advanced Research Institute for Medical Science, Tokyo Women's Medical University Dr. Hiroyuki Takeda | ProteoScience Center, Ehime University, Department of Proteo-Drug Discovery Science Dr. Tomoya Tsukazaki | Nara Institute of Science and Technology, Graduate School of Advanced Science and Technology, Bioscience Area, Structural Life Science Dr. Masafumi Doi | Daiichi Sankyo RD Novare Co., Ltd., Biological Evaluation Research Department, Discovery ADMET Group

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[Exhibition Information] 25th Annual Meeting of the Japanese Society for Protein Science

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We would like to inform you that we will be exhibiting our products at the 25th Annual Meeting of the Japanese Society for Protein Science. If you plan to attend, please feel free to stop by. ❚ 25th Annual Meeting of the Japanese Society for Protein Science Date: June 18 (Tuesday) - June 20 (Thursday), 2025 Venue: Acurie Himeji Exhibition Booth: For details, please visit the official website of the Japanese Society for Protein Science. URL: https://aeplan.jp/pssj2025/ ❚ Products to be Exhibited - Transporter Measurement Device | SURFE2R N1 This device allows for label-free and real-time direct measurement of transporter currents without using fluorescent probes or radiolabeled ligands. - Artificial Lipid Bilayer Experimental Device | Orbit mini This device simplifies the challenging tasks of forming lipid membranes, reconstructing membrane proteins, and measuring single-channel currents in experiments using artificial lipid bilayers, all with just a micropipette. - Liposome Preparation Device | Vesicle Prep Pro This single device enables easy preparation of liposomes without hassle, accommodating various lipid conditions (such as DPhPC, DPPC, DOPC, etc.).

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ナニオンテクノロジーズジャパン

ナニオンテクノロジーズジャパン 東京ラボ(東京大学内)

Pharmaceuticals and Biotechnology

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Nanion Technologies is a scientific instrument manufacturer founded in 2002 in Munich, Germany, specializing in the automation of electrophysiology experiments. We enable the automation of electrophysiology experiments, supporting not only ion channel research but also a wide range of membrane protein-related studies. We offer a broad product lineup, including our industry-leading automated patch clamp system, transporter activity measurement systems, artificial lipid bilayer experimental devices, liposome production devices, and impedance, extracellular potential, and contraction force measurement systems for iPS-derived cardiomyocytes. These systems have been adopted by many universities, pharmaceutical companies, and research institutions both domestically and internationally, and are highly regarded. For inquiries about our products, requests for introductions, demo requests, or catalog requests, please contact us or our authorized distributors. Additionally, feel free to consult us about visiting our Tokyo lab (Meguro Ward) to see the systems and experiments. Mail: info@nanion.jp

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