[Seminar Announcement] Ion Channel Forum 2023

An automated patch clamp system capable of meeting all needs, from small-scale screening projects to high-throughput screening.

Designed to seamlessly integrate fully automated compound screening into the drug discovery process, it provides the best performance in high-throughput screening of ion channels in drug discovery, pharmacology, safety, pharmaceutical research and development, and exploratory screening departments. Additionally, by using the 32-well mode, it can be optimized for small-scale compound screening and projects. ■ Simultaneous measurement of 384 cells ■ 20,000 data points per day ■ High giga-seal success rate ■ Supports a variety of ion channel targets and enables rapid assay system development ■ Measurement of action potentials using current clamp is also possible ■ Extracellular/intracellular perfusion is possible ■ High-speed external solution exchange (up to 110 µl/s) is possible ■ Measurement section and 12 decks can be individually temperature controlled (temperature range: 10–37°C) ■ Compound plate preparation on the deck is possible ■ Single & multi-well chips available (in-house manufactured) ■ Borosilicate glass chips reduce compound adsorption ■ Approximately 8 hours of unmanned operation is possible ■ Comes with powerful analysis software ■ Validated system for CiPA

• Other physicochemical equipment
• Analytical Equipment
• Patch clamp system

No pipetting operations are required during the experiment. It is equipped with a benchtop dispensing device that can automatically measure up to 48 cells continuously in an auto patch clamp system.

This is a tabletop-sized auto patch clamp system that can simultaneously measure up to 8 cells with giga-seal formation. With easy experimental setup, stable whole-cell recordings, and sophisticated software, it enables highly efficient compound ion channel screening. ■ Equipped with a dispensing device, allowing for fully automated experiments (measurements) ■ Simultaneous measurement of 4 cells / 8 cells (up to 48 cells can be measured continuously) ■ 250 to 600 data points per day ■ Automation from giga-seal formation to whole-cell formation ■ Compatible with voltage-dependent and ligand-dependent channels ■ Measurement of action potentials using current clamp is also possible ■ Dynamic clamp capability (optional) ■ Temperature control and extracellular/intracellular perfusion possible ■ Cooling plate allows for cooling of cells and compounds ■ Borosilicate glass chips reduce compound adsorption ■ Comes with excellent analysis software

• Other physicochemical equipment
• Analytical Equipment
• Patch clamp system

A world-class patch clamp system that is easy to operate for anyone, allowing for simple data acquisition and verification.

This is a patch clamp system of the world's smallest class that can perform gigaseal recordings, optimal for safety testing/toxicity testing/pharmacological testing/screening of compounds at the cellular level in the functional structural analysis of ion channels, research on related diseases, and drug development processes. 【Features】 ■ No need for manual patch clamp experience or difficult operations ■ No need for microscope, vibration table, manipulator, Faraday cage, or puller ■ 20 to 50 data points per day ■ Automation from gigaseal formation to whole cell formation ■ Compatible with voltage-dependent, ligand-dependent, and temperature-dependent channels ■ Options available for research on channel rhodopsins and mechanosensitive channels using light stimulation ■ Measurement of action potentials using current clamp is also possible ■ Supports a wide range of applications and enables rapid assay system development ■ Reduces compound adsorption with borosilicate glass chips ■ Optional temperature control (10 to 50°C), capable of extracellular/intracellular perfusion ■ Can be integrated with amplifiers such as HEKA and Axon *For details, please refer to the catalog available for download in PDF.

• Other physicochemical equipment
• Analytical Equipment
• Patch clamp system

A patch clamp system that incorporates a patch clamp amplifier, achieving miniaturization and reduction of installation costs, allowing for easy data acquisition and verification.

This is a world-class patch clamp system capable of performing gigaseal recordings, optimal for safety testing/toxicity testing/pharmacological testing/screening of compounds at the cellular level in the functional structural analysis of ion channels, research on related diseases, and drug development processes. ■ No experience with manual patch clamping or difficult operations required ■ No need for microscope/vibration isolation table/manipulator/Faraday cage/puller ■ 20 to 50 data points per day ■ Automation from gigaseal formation to whole cell formation ■ Compatible with voltage-dependent and ligand-dependent channels through pipetting ■ Measurement of action potentials using current clamp is also possible ■ Supports a wide range of applications, enabling rapid assay system development ■ Reduces compound adsorption with borosilicate glass chips

• Other physicochemical equipment
• Analytical Equipment
• Patch clamp system

Easily measure channel activity at the molecular level.

【Measurement Target Examples】 Ion channels (voltage-dependent, ligand-dependent, temperature-sensitive), DNA nanopores, antimicrobial peptides, toxins, etc. In experiments using artificial lipid bilayers, the formation of lipid membranes, reconstitution of membrane proteins, and measurement of single-channel currents can be easily performed. Purified target membrane proteins (such as ion channels in vivo or artificial ion channels) can be reconstituted on artificially formed lipid bilayers, allowing for the evaluation of drug effects and functional/structural analysis. ■ Simultaneous formation and measurement of 4 channels of artificial lipid bilayers is possible ■ Lipid membranes can be formed with just pipetting operations ■ No need for microscope, vibration isolation table, manipulator, or Faraday cage ■ Direct reconstitution of target membrane proteins or membrane fusion with proteoliposomes ■ Temperature control (10–50°C) available (optional) ■ Palm-sized, easy connection via USB

• Other physicochemical equipment
• Analytical Equipment

Easily measure channel activity at the molecular level.

【Measurement Target Examples】 Ion channels (voltage-dependent, ligand-dependent, temperature-sensitive), DNA nanopores, antimicrobial peptides, toxins, etc. Experiments using artificial lipid bilayers allow for easy formation of lipid membranes, reconstitution of membrane proteins, and measurement of single-channel currents. It is possible to reconstitute purified target membrane proteins (such as ion channels found in vivo or artificial ion channels) on artificially formed lipid bilayers for drug action evaluation and functional/structural analysis. By rapidly and automatically forming 16-channel artificial lipid bilayers at once and conducting fully simultaneous measurements, researchers are freed from the burdens of the painting method in experiments using artificial lipid bilayers. ■ Simultaneous formation and measurement of 16-channel artificial lipid bilayers is possible ■ Automatic lipid membrane formation using a stirrer bar ■ No need for microscope, vibration isolation table, manipulator, or Faraday cage ■ Direct reconstitution of target membrane proteins or membrane fusion with proteoliposomes ■ Temperature control available (10–50°C)

• Other physicochemical equipment
• Analytical Equipment

Direct measurement of transporter currents in a label-free and real-time manner without using fluorescent probes or radiolabeled ligands.

Currently, the mainstream method for evaluating transporter activity is the uptake assay using RI-labeled substrates. However, there are several issues, such as the need for specialized experimental facilities, the complexity of waste liquid treatment, the fact that the desired substrates are not always commercially available as RI-labeled, and the measurement of endpoints after uptake. SURFE²R (Surface Electrogenic Event Reader) technology does not require RI labeling, specialized experimental facilities, or waste liquid treatment, and it allows for real-time evaluation of the activity of transporters (symporters, exchangers, unipoters) and pumps. ■ Direct measurement of transporter currents using Solid Supported Membrane (SSM) ■ Experiments can be conducted using membrane fragments prepared from biological membranes or proteoliposomes reconstituted with the target membrane proteins ■ Light stimulation is possible (optional) ■ An all-in-one device that integrates a dispensing machine, measurement section, and computer ■ 150 data points per day

• Other physicochemical equipment
• Analytical Equipment
• Other Analysis

Direct measurement of transporter currents in a label-free and real-time manner without using fluorescent probes or radiolabeled ligands.

Currently, the mainstream method for evaluating transporter activity is the uptake assay using RI-labeled substrates. However, there are several issues, such as the need for specialized experimental facilities, complicated waste disposal processes, the fact that the desired substrates are not always commercially available as RI-labeled, and that the endpoint is measured after uptake. The SURFE²R (Surface Electrogenic Event Reader) technology does not require RI labeling, does not need specialized experimental facilities or waste disposal, and allows for real-time evaluation of the activity of transporters (symporters, exchangers, unipoters) and pumps. ■ Direct measurement of transporter currents using Solid Supported Membrane (SSM) ■ Experiments can be conducted using membrane fragments prepared from biological membranes or proteoliposomes reconstituted with the target membrane proteins ■ Simultaneous measurement in 96 wells ■ 10,000 data points per day

• Other physicochemical equipment
• Analytical Equipment
• Other Analysis

Measurement of impedance and extracellular potential of iPS-derived cardiomyocytes.

This is a hybrid cardiotoxicity screening device capable of impedance measurement and extracellular potential measurement similar to MEA. It can detect not only cardiomyocytes but also the minute contractions of cancer cells and liver cells due to the effects of compounds. ■ Simultaneous measurement of impedance and extracellular potential ■ 96-well simultaneous measurement ■ Label-free measurement ■ Long-term monitoring capability ■ Electrical pacing & optical pacing (optional) ■ Comes with an incubation system (temperature, humidity, and CO2 control) ■ Includes multifunctional and excellent data analysis and graph creation software ■ Validated human iPS cells: iCell, iCell², AXOL CM, Cardiosight-S, MiraCell Cardiomyocytes, etc. ■ Compact desktop size: W20.5 x D18 x H11.7cm / 3.5kg (main unit)

• Other physicochemical equipment
• Other Analysis

The Langeendorff method has been transformed into the latest high-throughput technology, allowing for the measurement of contractile force in cardiomyocytes under physiological conditions similar to the natural environment of cardiac tissue.

The FLEXcyte 96, which transforms the conventional Langendorff method into the latest high-throughput technology, can measure the contractile force (mN/mm²) of cardiomyocytes for cardiotoxicity and safety evaluation, as well as drug screening, under physiological conditions similar to the native cardiac tissue environment, without missing even slight responses to cytotoxicity, regardless of whether in the chronic or acute phase, simultaneously in 96 wells. ■ Simultaneous measurement in 96 wells ■ Label-free measurement ■ Long-term monitoring possible ■ Optical pacing (optional) ■ Comes with an incubation system (temperature, humidity, CO2 control) ■ Includes multifunctional excellent data analysis and graphing software ■ Validated human iPS cells: iCell, iCell², AXOL CM, Cardiosight-S, MiraCell Cardiomyocytes, etc. ■ Compact desktop size: W20.5 x D18 x H11.7cm / 3.5kg (main unit)

• Other physicochemical equipment
• Other Analysis

[Speaker] Daisuke Imaizumi, President and CEO, Infra Commons Inc. [Key Lecture Content] The "Software-Defined Warfare" led by the U.S. Department of Defense is establishing a new model of warfare centered on AI, autonomous drones, and real-time command and control. This seminar will explain the U.S. strategic shifts, including the Replicator concept, JADC2, and the rise of Palantir and Anduril, while delving into the essence of the structural transformation facing Japan's defense industry. Through the establishment of Anduril's Japanese subsidiary, the "purely domestic drone" concept, and Palantir's data infrastructure and generative AI deployment, we will present how companies like Mitsubishi Heavy Industries, Kawasaki Heavy Industries, Fujitsu, and NEC can play a central role in Japan-U.S. collaboration. We will provide practical insights for existing industries to carve out paths as "co-creation partners" rather than "enemies" in the AI and software-driven era. This is a must-see lecture for rethinking the future of the defense industry.

[Key Lecture Content] 1. Quantum Technology Opening the Future: The Cutting Edge of Quantum Communication Promoted by the Ministry of Internal Affairs and Communications Yuichiro Yano, Deputy Director, Research Promotion Office, Technology Policy Division, International Strategy Bureau, Ministry of Internal Affairs and Communications 1. Basics of Quantum Technology and the Role of the Ministry of Internal Affairs and Communications 2. The Future Brought by Quantum Technology and Government Strategy 3. Research and Development and Quantum Security Bases 4. Social Implementation of Quantum Technology and Use Cases 5. International Initiatives and Future Prospects 6. Q&A / Business Card Exchange 2. The Value and Potential of Quantum Cryptography in the Post-Quantum Era Go Kato, Director, Quantum ICT Research Laboratory, Future ICT Research Institute, National Institute of Information and Communications Technology 1. The Origin of the Security of Quantum Cryptography 2. Current Status of Quantum Cryptography Devices 3. Current Issues and Potential of Quantum Cryptography Technology 4. Long-term Prospects for Future Technological Development of Quantum Cryptography 5. Q&A / Business Card Exchange

[Key Lecture Content] 1. Trends and Future Prospects of Physical AI Hiroshi Kondo, Deputy Director and Expert, Advanced Technology Lab, Japan Research Institute, Ltd. 1. What is Physical AI? 2. Technological trends of generative AI behind Physical AI 3. Examples and research trends of Physical AI 4. Future prospects 5. Q&A / Business card exchange 2. The Future Opened by Physical AI: NVIDIA's Initiatives and Prospects Ken Arai, Senior Manager, Robotics Developer Relations, Enterprise Business Division, NVIDIA Corporation 1. What does NVIDIA perceive as "Physical AI"? 2. Accelerated computing supporting technological evolution 3. The role of digital twins and the importance of synthetic data generation 4. Learning and inference of Physical AI models 5. Implementation examples of Physical AI 6. Q&A / Business card exchange

We are pleased to announce the archive distribution of our seminar titled "New Plan 'Mojitori Plus' Debuts! From Paper to Data! The First Step in Internal DX with Mojitori." 'Mojitori' allows you to convert text from photos, images, PDF files, and more into data, automatically inputting it into various fields in kintone. In this seminar, we will clearly explain the basic functions and usage of Mojitori. Additionally, we will provide detailed explanations about the Plus plan and the document-focused Mojitori, which were added in the major update in November. 【Recommended for】 - Those who are struggling with frequent transcription errors due to manual data entry. - Those who wish to digitize documents currently stored on paper. 【Timetable】 - Overview of Mojitori's functions - Overview of Mojitori Plus's functions - Details and pricing of each plan - Q&A session We look forward to your registration.

Innovating material development at the nano level through high-speed molecular simulation and machine learning With the advancement of molecular simulation technology, it has become possible to handle nano-level phenomena through computer simulations. Additionally, the combination of simulation and machine learning is expanding the range of possibilities. Schrödinger supports the enhancement of analytical power, efficiency, and reduction of development time in your material development using the latest molecular simulation and machine learning technologies, as well as techniques that integrate both. At our exhibition booth, specialized technicians will explain the latest technologies and answer questions from attendees. *During the event, we will hold a seminar at our booth. Theme: "Seeing Inside Materials at the Nano Level" - New Material Development through Simulation and Machine Learning We will introduce examples of predicting physical property values of various materials on a computer. You can experience each software firsthand. 【Exhibition Information】 Exhibition Name: nano tech Dates: January 28-30, 2026 Venue: Tokyo Big Sight, West Hall 3 Booth Number: 3W-H07 Exhibition Zone: [Materials] Material Zone