Experiment on the production of medical radioactive substances using a linear accelerator.
Social Infrastructure (Saitama University Research Seed Collection 2025-27 p.1)
Keywords: atomic nucleus, radioactive materials, accelerator, nuclear data, radiation therapy, radiation diagnosis
The atomic nucleus is located at the center of the atom and is composed of numerous neutrons and protons. The interactions between the constituent particles and the overall movement of the nucleus exhibit various properties. Phenomena such as nuclear fission and the emission of gamma rays arise from the individuality of the atomic nucleus. The fission of heavy nuclei, such as uranium, releases a significant amount of energy, which is applied in power generation. In the medical field, radiation is utilized, and medical radioactive materials (RIs) used for cancer treatment and diagnosis are produced domestically using accelerators. The commonly used 99Mo is generated in reactors and has a short half-life (66 hours), and while it is airlifted from overseas, there is always a concern that supply may be interrupted due to disasters or other issues. To secure a domestic supply line for medical RIs, it is essential to establish efficient and pure methods for producing alternative RIs. Using the linear accelerator at the RIKEN research institute, we are investigating practical and efficient incident energies for the production of new medical RIs. By employing activation methods and layered foil techniques, we can examine the energy dependence of the production cross-section all at once.
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Shuichiro Ebata, Assistant Professor Graduate School of Science and Technology, Department of Materials Science, Fundamental Materials Area 【Recent Research Themes】 ● Calculation of the charge polarization distribution of fission fragments using microscopic mean-field models ● Theoretical study of nuclear structure through photoreactions ● Structure of deformed atomic nuclei in the shape of a pear
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【Appeal Points to the Industry】 ● Exploration of new medical radioisotopes (RIs) applicable to both treatment and diagnosis ● Exploration of effective production methods for medical RIs ● There are few groups in the world obtaining nuclear data for medical RIs ● Patent "Method for Producing Radioactive Yttrium and Radioactive Pharmaceutical" Publication No. 2017-090366 【Examples of Practical Application, Use Cases, and Utilization】 ● The production cross-section of Neodymium-140, an alternative RI candidate for PET scans, was obtained by bombarding Praseodymium-141 with deuterons ● The acquired data has been included in the IAEA database, serving as a foundation for international nuclear development
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Target holder installed at the linear accelerator of the RIKEN Institute.
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The Saitama University Open Innovation Center is a center that functions as a liaison office for industry-academia-government collaboration. It consists of three departments: the Industry-Academia-Government Collaboration Department, the Intellectual Property Department, and the Startup Support Department, each staffed with coordinators well-versed in various fields. The center's activities include solving technical challenges in companies, supporting the implementation of joint research, and conducting technology transfer aimed at introducing and utilizing Saitama University's intellectual property.
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