We will explore the mechanisms and applications of enzymes!
Monozukuri (Saitama University Research Seed Collection 2025-27 p.39)
Keywords: metal, enzyme, cofactor, X-ray crystallography, PLP, porphyrin, cluster, catalyst, redox
Enzymes are said to be excellent catalysts that enable highly active and regio- and stereoselective transformations under mild conditions of normal temperature and pressure. However, what kinds of enzyme reactions can be realistically utilized? To effectively harness enzymes for targeted reactions, it is important to understand their characteristics from a molecular perspective. We are conducting research focused on understanding enzymes and enzyme reactions from a chemical viewpoint, as well as exploring the utilization of enzymes with non-natural substrates. In particular, we are creating new added value in "metalloenzymes" and "PLP enzymes," which are expected to be utilized due to their ability to perform complex reactions.
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Takashi Fujishiro, Professor Graduate School of Science and Engineering, Department of Life Sciences, Molecular Biology Area 【Recent Research Themes】 ● Biosynthesis of metal cofactors ● Molecular evolution and diversity of metalloenzymes, development of new reactions ● Utilization of PLP enzyme reactions for substance production
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【Appeal Points to the Industry】 ●We have extensive research achievements in metal enzymes and PLP enzymes.
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The three-dimensional structure of the Ni-inserting enzyme CfbA in the biosynthesis of Ni-borifirin and the Ni-insertion catalytic reaction.
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The Saitama University Open Innovation Center is a center that functions as a liaison office for industry-academia-government collaboration. It consists of three departments: the Industry-Academia-Government Collaboration Department, the Intellectual Property Department, and the Startup Support Department, each staffed with coordinators well-versed in various fields. The center's activities include solving technical challenges in companies, supporting the implementation of joint research, and conducting technology transfer aimed at introducing and utilizing Saitama University's intellectual property.