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  6. Cleaning evaluation: Microbial TOC recovery rate and linearity

Cleaning evaluation: Microbial TOC recovery rate and linearity

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last updated:May 26, 2025

セントラル科学
セントラル科学
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[Application Note] Reducing Microbial Contamination Risks with TOC

In the food and beverage industry, effective cleaning of manufacturing equipment is essential to deliver high-quality and safe products to consumers. It is particularly important to appropriately reduce the risk of contamination by microorganisms. According to the FDA, the primary cause of product recalls in the food and beverage industry in 2017 was product contamination by microorganisms. Therefore, proper cleaning processes are required to reduce microbial contamination. Additionally, it is important to have means to verify the effectiveness of the cleaning process. TOC (Total Organic Carbon) is a widely adopted non-specific analytical method for detecting potential contaminants such as product residues, detergents, and microorganisms. To use TOC, it is necessary to consider the recovery rates and linearity of substances that may remain after cleaning. While testing for chemical contaminants and compounds using TOC is common, there is limited information regarding the recovery rates of microorganisms. By using the Sievers M9 TOC analyzer, it is possible to detect microbial residues at lower concentrations than visual inspection in cleaning evaluations. TOC analysis is effective for measuring residues, monitoring cleaning processes, and reducing overall risks. This enables more accurate and efficient microbial management in the cleaning evaluation of manufacturing equipment.

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Cleaning evaluation: Microbial TOC recovery rate and linearity

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  • Related Link - https://aqua-ckc.jp/cleaningvaridation
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Cleaning validation

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Cleaning evaluation: Microbial TOC recovery rate and linearity

Cleaning evaluation: Microbial TOC recovery rate and linearity

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TOC Analyzer for Pharmaceuticals Sievers M9

TOC Analyzer for Pharmaceuticals Sievers M9

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セントラル科学

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Since our establishment in 1967, we have been dedicated to the development and dissemination of water quality measurement devices that anyone can use quickly, easily, and with high precision. In today's world, where the effective use of water, a limited resource, is required alongside environmental conservation, we aim to be a total solution provider that responds to all water environments by utilizing our water quality measurement devices, technology, and services. Furthermore, leveraging the latest technology and years of know-how, we are committed to delivering user-friendly and reliable water quality measurement devices more affordably, quickly, and widely.

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