Utilizing the power of microorganisms.
Life (Saitama University Research Seed Collection 2025-25 p.116)
Keywords: Microbial utilization, microbial breeding, fermentation production, microbial environmental purification.
The cellulase complex "cellulosome" derived from anaerobic bacteria can efficiently decompose plant cell walls (biomass) and holds the potential to contribute to a circular society in the future. However, the production strains of cellulosomes are anaerobic, making cultivation difficult. Therefore, we are working on the secretion production of cellulosomes using Bacillus subtilis (a relative of natto bacteria), which has been studied alongside Escherichia coli for a long time and has accumulated various insights. There is also the possibility of secreting other useful proteins using Bacillus subtilis.
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Satoshi Matsuoka, Associate Professor Graduate School of Science and Technology, Department of Life Sciences, Field of Molecular Biology 【Recent Research Themes】 ● Analysis of the molecular mechanisms of glycolipids involved in the cell membrane permeability of Bacillus subtilis ● Analysis of the lipid composition and stress response of Escherichia coli ● Secretion production of useful proteins by Bacillus subtilis ● Breeding of useful natto bacteria through modification of membrane lipid composition
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【Appeal Points to the Industry】 ● Fermentation production of useful substances using Bacillus subtilis ● Isolation and identification of microorganisms (bacteria) ● Doi RH, Matsuoka S. "Structure, Function, and Utilization of the Cellulase Complex 'Cellulosome'" BioScience and Industry 65(3), 121-125. (2007) 【Examples of Practical Applications, Case Studies, and Utilization】 ● Secretion production of cellulase using Bacillus subtilis ● Production of useful substances by microorganisms (bacteria) ● Potential applications in environmental purification using microorganisms (bacteria)
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Production of cellulase secretion derived from anaerobic bacteria using Bacillus subtilis.
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The Saitama University Open Innovation Center is a center that functions as a liaison office for industry-academia-government collaboration. It consists of three departments: the Industry-Academia-Government Collaboration Department, the Intellectual Property Department, and the Startup Support Department, each staffed with coordinators well-versed in various fields. The center's activities include solving technical challenges in companies, supporting the implementation of joint research, and conducting technology transfer aimed at introducing and utilizing Saitama University's intellectual property.