Tohoku Univ. Technology : Ammonia Adsorbent and removal method : T19-084
Reductions in glucose levels are suppressed, and cultivate cells more efficiently
In recent years, there has been a demand for mass culture of cells in fields such as pharmaceutical manufacturing. Ammonia accumulating in the culture medium must be removed in order for cells to grow stably during culture. Ammonia is known as a typical waste product that adversely affects cells. Until now, waste products were removed from the culture using the principle of dialysis. However, in order to remove waste products sufficiently, the volume of the component preparation liquid tank was set to be more than 10 times the volume of the cell culture tank, so there was a problem that the required volume of liquid was enormous and costly. The present invention made it possible to provide a new ammonia removal technology. Embodiments of the present invention are an ammonia adsorbent and an ammonia removal method. The ammonia adsorbent of the present invention comprises at least one substance among L-type zeolite, ferrierite, ZSM-5 type zeolite, a strong acid cation exchange resin and a Prussian blue type complex. Thus, cells can be cultured more efficiently.
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The revenue generated from technology transfer is reinvested as new research funding for universities and researchers, and is utilized to create further research outcomes. To ensure the smooth operation of this cycle, known as the "Intellectual Creation Cycle," we will vigorously promote technology transfer. The types of seeds we handle include patents, know-how, databases, and programs. We have established a collaborative framework by signing basic technology transfer agreements with the following universities (as of June 1, 2025): Tohoku University, Hirosaki University, Iwate University, Akita University, Fukushima University, Yamagata University, Tohoku Gakuin University, Iwate Medical University, Fukushima Medical University, Aizu University, Miyagi University, Hokkaido University, Muroran Institute of Technology, and Showa Medical University.
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