Comprehensive characterization for the development and manufacturing of safe and highly effective vaccines.
Efficient evaluation of potency, safety, and stability using light scattering detectors and LC-MS.
To quickly deliver safe and highly effective vaccines to the market, thorough characterization analysis is necessary. By using light scattering detectors, a wealth of information can be obtained regarding the vaccine's size, aggregation, stability, interactions, composition, and conformation. By combining MALS (Multi-Angle Light Scattering) and DLS (Dynamic Light Scattering), information about the conformation (shape and structure) of molecules can be derived from the ratio of Rh (hydrodynamic radius) to Rg (radius of gyration). Furthermore, by combining separation techniques such as SEC (Size Exclusion Chromatography) and FFF (Field Flow Fractionation), high-resolution size and molecular weight distribution measurements can be achieved. In LC-MS, peptide mapping allows for the confirmation of primary sequences and monitoring of post-translational modifications. By clicking [Submit], you are deemed to have agreed that Waters will use and process the information provided on this site in accordance with Waters' Terms of Use and Privacy Notice. Terms of Use and Privacy Notice www.waters.com/legalandprivacy
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basic information
Related Products - Multi-Angle Light Scattering (MALS) Detector DAWN Series - Dynamic and Static Light Scattering Measurement Device DynaPro NanoStar 2 - Light Scattering/Zeta Potential Measurement Device DynaPro ZetaStar - Field Flow Fractionation (FFF) Eclipse - Low Adsorption UPLC System ACQUITY Premier - Column for Gene Therapy Drug Analysis GTxResolve (Wide Pore SEC Column Suitable for Analyzing Macromolecules and Aggregates like Vaccines)
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Applications/Examples of results
- Aggregate content - Purity - Full/Empty of LNPs and AAVs If you have any requests for application notes, demo analyses, etc., please feel free to contact us.
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Company information
Waters Corporation, headquartered in Milford, Massachusetts, USA, has played a pioneering role as a specialized manufacturer of liquid chromatography since its establishment in 1958. Actively engaged in the development of new products and technologies, it has grown into an international group company that supplies not only high-performance liquid chromatography but also mass spectrometers (MS) and thermal analysis instruments. Waters Japan started operations in 1973 (Showa 48) as the Japanese base of Waters Corporation. Inheriting the corporate ethos of the U.S. headquarters, we have made "Customer Success" our mission and continue to provide innovative technologies and lab solutions.
