Direct measurement of the mass of giant molecules ranging from megadaltons to gigadaltons with just a few µL of sample.
By clicking [Send], you are deemed to have agreed that Waters will use and process the information provided on this site in accordance with the Waters Terms of Use and Privacy Notice. Terms of Use and Privacy Notice www.waters.com/legalandprivacy CDMS stands for Charge Detection Mass Spectrometer, which separates individual ions and simultaneously captures both m/z and charge to calculate the true mass of molecules with unparalleled accuracy. It can directly and accurately measure large and heterogeneous molecular species, such as viruses and protein complexes, that traditional techniques cannot handle. 【Features】 - Accurate - Direct measurement of charge and mass for individual ions without the need for deconvolution. - Fast - Results can be obtained in less than 10 minutes, streamlining workflows and accelerating decision-making. - Clear - Reliable identification of empty particles, partial particles, and complete particles of viral vector capsids. - High sensitivity - Detectable with up to 1/100th of the sample amount compared to traditional methods.
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basic information
Ionization method: nanoESI Mass range: >50MDa Detector: Electrostatically linear ion trap Type: Benchtop type
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Applications/Examples of results
High-precision and accurate mass measurement of ultra-high mass modalities such as gene therapy drugs, viral vectors, virus-like particles (VLP), RNA, protein complexes, and vaccines.
Detailed information
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It is now possible to directly measure the mass of large molecules that could not be measured until now. High-mass molecules (with a molecular weight of over 100 M Da), such as viruses and protein complexes, which could not be addressed by conventional mass spectrometry techniques, can now be measured directly and with high precision.
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Benefits obtained from the use of Xevo CDMS. Charge Detection Mass Spectrometry (CDMS) complements traditional measurement methods.
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An example of AAV characterization using CDMS. Subpopulations of capsids are separated and identified by accurate mass. The peak area ratio allows for the quantification of empty particles, partial particles, and full particles. A 2D charge and m/z plot enables a clearer assessment.
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Company information
Waters Corporation, headquartered in Milford, Massachusetts, USA, has played a pioneering role as a specialized manufacturer of liquid chromatography since its establishment in 1958. Actively engaged in the development of new products and technologies, it has grown into an international group company that supplies not only high-performance liquid chromatography but also mass spectrometers (MS) and thermal analysis instruments. Waters Japan started operations in 1973 (Showa 48) as the Japanese base of Waters Corporation. Inheriting the corporate ethos of the U.S. headquarters, we have made "Customer Success" our mission and continue to provide innovative technologies and lab solutions.
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