Tohoku Univ. Technology ：Supercritical & Subcritical Fluid System：T22-178
High-Productivity, High-Quality Manufacturing for Pharmaceutical and Food Ingredients
The inventors have developed a unique subcritical solvent separation method using three green solvents—CO₂, ethanol, and water—to enable safe, eco-friendly production of pharmaceutical and food ingredients. Conventional supercritical and subcritical processes often face slurry freezing and clogging due to adiabatic expansion, reducing productivity and increasing maintenance time and cost. The proposed system prevents these issues by creating a controlled pressure difference between gas and liquid phases in the separation column, enabling a safer and more efficient extraction and manufacturing process. ◎High productivity enabled by continuous separation and collection ◎Handles slurry without clogging, reducing pretreatment time and preventing degradation of target compounds ◎No harmful organic solvents, ensuring safer and cleaner operations
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The revenue generated from technology transfer is reinvested as new research funding for universities and researchers, and is utilized to create further research outcomes. To ensure the smooth operation of this cycle, known as the "Intellectual Creation Cycle," we will vigorously promote technology transfer. The types of seeds we handle include patents, know-how, databases, and programs. We have established a collaborative framework by signing basic technology transfer agreements with the following universities (as of June 1, 2025): Tohoku University, Hirosaki University, Iwate University, Akita University, Fukushima University, Yamagata University, Tohoku Gakuin University, Iwate Medical University, Fukushima Medical University, Aizu University, Miyagi University, Hokkaido University, Muroran Institute of Technology, and Showa Medical University.
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