Small volume dissolution and membrane permeation measurement system 'μDISS・μFLUX'
Pion µDISS・μFLUX
Immediate data acquisition with fewer APIs. Significantly reduces time and costs from measurement to analysis, contributing to cost reduction in formulation research and improved evaluation speed.
The μDISS and μFLUX are small-volume measurement systems that can evaluate solubility and membrane permeability with a small amount of API. They allow testing to proceed even in the early stages of development when the API is limited. ■ μDISS It enables dissolution testing on a small scale. Since dissolution data can be obtained immediately after measurement, sampling and waiting times are minimized. By shortening the process up to data analysis, it contributes to speeding up the overall research. ■ μFLUX It can simultaneously evaluate solubility and membrane permeability, allowing for a more realistic prediction of in vivo absorption. It enables the understanding of differences in absorption even with small amounts of API, and by reducing the workload, it achieves efficiency in both time and cost. It also allows for the examination of multiple conditions and comparative tests without difficulty. Both systems are suitable evaluation solutions for research environments that want to obtain materials for formulation design and formulation consideration more quickly and reliably. For more details, please check the "Download Catalog" below or feel free to contact us.
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basic information
* Achieving solubility measurement with a small sample By connecting to Rainbow, in-situ UV measurements can be performed without sampling, enabling solubility measurements with a small volume. This allows for solubility measurement without losing valuable APIs in the early stages. * Evaluation of supersaturation duration is possible By connecting to Rainbow, it is also possible to evaluate supersaturation. Real-time concentration detection makes it easy to assess the duration of supersaturation. * Obtaining data with high correlation to PK data Results from testing different formulations of APIs with µFLUX have shown a significant correlation between the concentration in the µFLUX acceptor chamber during animal experiments and the AUC of the plasma concentration profile when compared to published PK data. * Evaluation of Food Effect By changing the test solution used on the donor side to FaSSIF and FeSSIF, it is possible to validate the Food Effect.
Price range
P7
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Applications/Examples of results
For more details, please refer to the catalog or feel free to contact us.
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Company information
Physio-Machina Co., Ltd. is a company that primarily sells products such as formulation development equipment and dissolution testers, conducts validation and calibration of peripheral devices, and engages in the import and export of software and various equipment. Additionally, it actively provides translation and interpretation of technical documents and seminars, as well as support for the creation of SOPs and conducts training sessions.
![[Case Study of Membrane Permeability Measurement System] Evaluation of Membrane Permeability Using μFLUX](https://image.mono.ipros.com/public/product/image/39f/2001515385/IPROS17391245031734486152.png?w=280&h=280)
