It has been announced that VX-150 and VX-548 target the Nav1.8 ion channel, showing potential for pain relief.
The paper using QPatch Compact focuses on the study of the inhibition of the Nav1.8 ion channel by two new analgesic compounds, VX-150 and VX-548.
The Nav1.8 channel is a major target in sensory neurons that detect pain and is extremely important for pain-related therapies.
This research, conducted by a professor's laboratory at Harvard Medical School, utilized the QPatch Compact semi-automated patch clamp system to perform voltage clamp recordings and analyze the effects of these compounds on Nav1.8 sodium currents.
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