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THz-Raman(R) Spectroscopy Probe

Raman probe for low wavenumber region measurement manufactured by Coherent (formerly Ondax)

We handle Raman probes for low wavenumber region measurements manufactured by Coherent (formerly Ondax). Peaks appear in the fingerprint region, which is called 200 to 1800 cm-1, representing the molecular structure of substances, including functional groups, geometric isomers, conformations, hydrogen bonding, and the state of chemical structures. The region below 200 cm-1 is referred to as the low wavenumber region. Peaks that represent structural information, such as the crystal form of compounds, appear, and it is known that in the low wavenumber region, the intensity of Raman scattered light is stronger than that in the fingerprint region. 【Applications of THz-Raman(R) Probe】 - Evaluation of physical properties such as polymorphism of pharmaceutical active ingredients - Evaluation of content uniformity of active ingredients in formulations - Crystal transformation of active ingredients - Co-crystal screening - Evaluation of polymorphism in fats and oils *For more details, please download the PDF or feel free to contact us.

  • Analytical Equipment and Devices

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Wide-area Raman probe

It is effective for measuring the Raman spectrum of samples with uneven dispersion of components.

In 2019, Raman spectroscopy was included in the seventeenth revision of the Japanese Pharmacopoeia as "Raman Spectral Measurement Method." This spectroscopy is known to be effective for the quantitative evaluation of active ingredients in a non-contact and non-destructive manner. In recent years, in addition to reflection methods, there have been numerous reports indicating its effectiveness in transmission methods and in evaluating the polymorphism of active ingredients. While there are reports suggesting that near-infrared spectroscopy is effective for process management, particularly in the quantification of active ingredients, there are also reports indicating that it is difficult to quantitatively evaluate active ingredients that are unevenly dispersed. Therefore, we conducted an evaluation and examination of the practicality of a wide-area Raman probe capable of collecting Raman scattered light from a broad range of areas for the quantitative evaluation of multiple crystal forms of active ingredients.

  • Spectroscopic Analysis Equipment

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PROXIMAL BALLPROBE Non-contact Wide Area Probe

Non-contact Raman probe that enables measurement of Raman spectra over a wide range.

The wide-area probe has an effective aperture diameter of 8mm, which is wider than that of a standard probe, allowing for the broad collection of Raman scattered light from samples. Additionally, the working distance (focal length) is 3cm, enabling non-contact measurements in the biopharmaceutical, pharmaceutical, and food sectors, thereby reducing the risk of cross-contamination and foreign matter intrusion during measurement.

  • Raman Spectrophotometer
  • Other photoanalytical instruments

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TH-Raman Probe for low wavenumber region measurement

The Raman spectrum in the low-frequency region can be measured non-contactly and non-destructively.

The TH-RamanProbe system consists of a control unit made up of a laser light source and power supply, and a probe that irradiates the sample with laser light and receives Raman scattered light from the sample. A special notch filter that cuts the excitation laser is built into the probe section. The probe, equipped with a sapphire lens that has high throughput, is available in two types: short focus and long focus, depending on the measurement purpose.

  • Analytical Equipment and Devices

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Single-use Raman probe

Biopharmaceuticals, pharmaceuticals, cell culture, Raman probes for fermentation measurement.

• Accurate and reproducible measurements are possible • Disposable probes for batch use in case of high costs • Can be sterilized by autoclave, SIP, EtO, or gamma radiation • Compatible with standard Pg13.5 ports • Specifications such as probe length can be customized

  • Raman Spectrophotometer

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