Immunoglobulin preparation with 10 times higher anti-inflammatory effect.
We propose an immunoglobulin preparation with significantly higher anti-inflammatory effects compared to conventional immunoglobulin preparations, along with its manufacturing method.
Intravenous immunoglobulin (IVIG) preparations have recently seen an increasing demand as treatments for autoimmune diseases such as Kawasaki disease. However, there are concerns about future supply issues since the raw materials are derived from plasma components obtained from many healthy donors. The new immunoglobulin preparation introduced here exhibits approximately ten times the anti-inflammatory effect compared to conventional products, which could significantly reduce the amount of raw materials used and also considerably lower costs. [Features] - A manufacturing method for galactosyl non-fucosylated (G2) serum IgG has been established. - (G2) IgG is a natural component found in the blood of healthy individuals, and by binding to the FcγIIIa receptor on natural killer (NK) cells, it suppresses immune overreaction and inflammation. - Its efficacy has been confirmed through experiments conducted on mice.
- 企業：山口ティー・エル・オー
- 価格：Other
