Methods for artificially controlling the blood-brain barrier function - Overcoming refractory neurological disorders.
We have discovered functional molecules that artificially and reversibly open and close the blood-brain barrier.
*Looking for partner companies for joint development* The blood-brain barrier (BBB) has an important function in preventing harmful substances from entering the brain and maintaining a healthy environment within it. However, due to the presence of the BBB, water-soluble drugs administered peripherally cannot be delivered to the brain, and conversely, it has not been possible to restore the function of the BBB once it has opened due to pathological conditions such as neurodegenerative diseases. Recently, Yamaguchi University has established a method to artificially and reversibly open and close the BBB. By identifying the key factors involved in the opening and closing of the BBB and utilizing its physiological functions, it is now possible to reversibly open the BBB under conditions with minimal concerns about side effects, paving the way for drug delivery to the brain, which has been challenging. Additionally, restoring the function of the pathologically opened BBB is expected to improve disease conditions. <Target Diseases> - Closing an opened BBB: cerebral infarction, diabetic retinopathy, Alzheimer's disease, Parkinson's disease, etc. - Opening a closed BBB: brain tumors, neurological diseases, etc. <Benefits for Companies> - The development of new, highly safe therapeutic drugs is now possible through a novel mechanism that allows for the artificial and reversible opening and closing of the BBB.
- Company：山口ティー・エル・オー
- Price：Other
