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For the pharmaceutical industry! 'Virus safety testing' using electron microscopy.

Safety testing using transmission electron microscopy! We have years of accumulated experience and achievements!

At the Flower Market Electron Microscopy Technology Research Institute, we offer contract services for "Virus Safety Testing" using electron microscopy. Under strict management in compliance with GLP/GMP, we conduct virus safety tests. For example, when producing biopharmaceuticals using CHO cells, it is necessary to perform electron microscopy observations in the retrovirus negative test based on the test items outlined in ICH Q5A and Q5D. Based on our years of accumulated experience and achievements, we provide our customers with highly reliable data. 【Features】 ■ Safety testing using transmission electron microscopy ■ Years of accumulated experience and achievements ■ Providing customers with highly reliable data *For more details, please refer to the PDF materials or feel free to contact us.

  • Contract Analysis

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[Case Analysis] Pathogenic Escherichia coli O-157

Analyzing a bacterium known as one of the causes of collective food poisoning using ×30,000 magnification with 1: TEM and 2: SEM!

We would like to introduce a case study of the analysis of "pathogenic Escherichia coli O-157" conducted by our company. "O-157" has recently become known as one of the bacteria responsible for foodborne outbreaks, and elucidating the mechanism of its verotoxin production is an urgent task. Bacteria have a cell wall surrounding them, making it difficult for chemicals such as fixatives to penetrate. The sample preparation method is fundamentally similar to that of animal tissues, but the image quality can be improved by extending the processing time and performing fixation at room temperature. 【Analysis Overview】 ■ Target of Analysis: Pathogenic Escherichia coli O-157 ■ Sample Preparation Method: Essentially similar to animal tissues - Image quality is improved by extending processing time and performing fixation at room temperature. *For more details, please refer to the PDF document or feel free to contact us.

  • Contract Analysis

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[Data] Case Study of Material System Analysis

It is possible to prepare sections ranging from 30nm to 5μm! This document introduces several case studies of material analysis!

This document is a collection of case studies summarizing material analysis conducted by Hanai Corporation's Electron Microscope Technology Research Institute. The "Ultra Microtome" is suitable for producing high-quality ultra-thin sections and cross-sections across a wide range of fields, including biological tissues, metal plating layers, inorganic deposition layers, and nanoparticles. Our company has started offering contract analysis services. We will conduct material analysis in collaboration with partner organizations. [Published Cases] - Structural analysis of liposomes - Structural analysis of HIPS - Structural analysis of lens cross-sections - Cross-sectional observation of candy bags - Morphological observation of metal particles using the dispersion method (metal microparticles/metal-supported carbon) *For more details, please refer to the PDF document or feel free to contact us.

  • Contract Analysis
  • Electron microscope
  • Other microscopes

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[Case Analysis] Hepatocytes (Pig Liver)

Insert photo ×7,000 Analysis of the cell membrane (×100,000)! It can be seen that the cell membrane has a double structure approximately 7nm wide.

We would like to introduce a case study of the analysis of 'hepatocytes (pig liver)' conducted by our company. The liver has many functions, including lipid and protein synthesis, metabolism and removal of drugs, and energy storage, most of which are composed of hepatocytes. There are also other components such as bile canaliculi (BC) and blood vessels (HS), within which blood cells (EC, Kf) can be observed. The inserted photo shows an enlargement of the cell membranes of adjacent cells, revealing that each cell membrane has a double structure approximately 7nm wide. Additionally, hepatocytes possess typical organelles that are often referenced when explaining the structure and function of general cells. [Analysis Overview] ■ Analysis Subject: Hepatocytes (pig liver) ■ It is evident that each cell membrane has a double structure approximately 7nm wide. ■ Hepatocytes have typical organelles that are frequently cited when explaining the structure and function of general cells. *For more details, please refer to the PDF document or feel free to contact us.

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