東洋発酵 List of Products and Services

- It is a material extracted from six carefully selected strains of koji mold (Aspergillus oryzae, Aspergillus luchuensis). - It contains over 200 beauty ingredients, including 20 types of amino acids and B vitamins. - It promotes the mRNA expression of profilaggrin, which is the precursor of NMF (Natural Moisturizing Factor). - It enhances the mRNA expression of hyaluronic acid synthase (HAS3) in epidermal keratinocytes. - It increases the mRNA expression of Kallikrein-7 (KLK7), which promotes the shedding of corneocytes during turnover. - It promotes skin turnover through the ATP production enhancement effect in epidermal keratinocytes. - It stimulates collagen production in fibroblasts. - The promoting effect on turnover in humans has been confirmed. - In a continuous use trial of skin koji water cosmetics in humans, improvements in stratum corneum moisture content, increased KLK7 activity, reduced stratum corneum shedding, as well as reductions in wrinkles, enhanced skin brightness, and increased skin elasticity were confirmed. Features of skin koji water, examples of cosmetic concepts, and examples of developed products. https://www.toyohakko.com/products/hadakojisui/

• Organic Natural Materials

"Protect your skin from external stimuli and achieve healthy, youthful skin!" - The ingredient is made from black rice "Kita no Murasaki," fermented with tofu-derived red koji mold (Monascus purpureus). - It complies with Chinese INCI standards and can be incorporated into cosmetics for the Chinese market. - It is a natural ingredient with a natural index of 1.0 (in accordance with ISO 16128). <Overview of Functional Features> 'Anti-inflammatory' Suppresses excessive production of NO and IL-6 during inflammation. (Patent pending) 'Antioxidant' Has the ability to eliminate reactive oxygen species and protect cells from reactive oxygen species and UVB. 'Hydration' Promotes the expression of hyaluronic acid synthase (HAS3) genes. 'Improvement of Barrier Function' Has a promoting effect on involucrin production. 'Anti-wrinkle and Firmness Improvement' Promotes collagen production in fibroblasts. 'Improvement of Turnover Function' Promotes the proliferation of epidermal keratinocytes. For features, benefits of incorporation, examples of cosmetic development, and informational videos about RICETECT, visit here: https://www.toyohakko.com/products/ricetect/

• Organic Natural Materials

"UNIFINE" is a fermented isoflavone anti-glycation ingredient that converts soybean-derived isoflavones into hydroxyl isoflavones through fermentation. Hydroxyl isoflavones not only have significantly greater antioxidant power than pre-fermentation isoflavones but also possess the ability to suppress the generation of glycation reaction products and promote their decomposition. This ingredient is suitable for product planning aimed at anti-aging, glycation countermeasures, and anti-metabolic syndrome measures. 【Features】 - A fermented ingredient made from soybean extract containing isoflavones, fermented with koji mold. - An anti-glycation ingredient with hydroxyl isoflavones as the active component (Patent No. 5318339). - Suppression and decomposition of glycation reaction products (CML, 3DG, pentosidine). - Anti-diabetic (improvement of glucose tolerance) and anti-obesity (suppression of fat accumulation) effects (patent pending). - Anti-glycation effects in the body through oral intake, suppression of carbonyl protein generation, and skin beautifying effects. - Effectiveness in suppressing glycation-related hair loss (patent pending). - Antioxidant capacity (DPPH, OH radical scavenging ability). - Cosmetic ingredient "UNIFINE-CO" is also available. For more details, please refer to the catalog or feel free to contact us.

• Organic Natural Materials

"ROSE CRYSTA-70" (High Concentration Rose Polyphenol) is a functional ingredient concentrated from polyphenols extracted from rose petal extract. It is an extract powder that is extracted, concentrated, and spray-dried from wild rose petals, containing over 70% polyphenols derived from rose petals. It has effects such as suppressing fat absorption after meals, inhibiting blood sugar level increases, improving skin elasticity, and whitening effects. [Features] ■ Suppresses fat absorption during meals ■ Works to inhibit blood sugar level increases after meals ■ Improves indicators of metabolic syndrome ■ Powerful antioxidant activity from polyphenols [Consumer Ingredient Introduction Page] https://toyohakko-healthcare.com/rose_crysta70/ For more details, please refer to the catalog or feel free to contact us.

• Organic Natural Materials

"ROSE CRYSTA" (Rose Petal Extract) is an anti-allergy material standardized with the active ingredient eugenol. It is an extract powder obtained from the petals of wild rose species, spray-dried, using approximately 220,000 rose petals for every 1 kg of this product. By inhibiting the binding of IgE to IgE receptors and suppressing the release of histamine, it makes allergy symptoms less likely to occur. It can also be used in combination with other ingredients that have different mechanisms, such as red clover extract and lactic acid bacteria. [Features] - Material suitable for Type I allergies - Confirmed IgE-IgE receptor inhibitory activity (Patent No. 4097300) - Suppresses the release of histamine, alleviating sneezing, runny nose, and itching - Expected to be effective not only during pollen seasons but also for perennial allergy symptoms - Whitening and skin beautifying effects For more details, please refer to the catalog or feel free to contact us.

• Organic Natural Materials

"IMMUNOL" is a material that has been fermented and powdered using plant-derived ingredients from acetic acid bacteria isolated from fruit (persimmons). The active component, glycolipid (lipopolysaccharide: LPS), is a structural component of the cell walls of Gram-negative bacteria, including acetic acid bacteria. It is expected to normalize the immune balance in the body and promote natural healing and skin metabolism. [Features] ■ Activates natural immunity ■ Activates macrophages, which are phagocytic cells Further activation of macrophages can be expected when used in combination with lactic acid bacteria. ■ Has the effect of suppressing IgE antibody-dependent allergies (Type I allergies), particularly expected to alleviate symptoms of hay fever and atopic dermatitis. ■ Promotes proliferation in fibroblasts and enhances hyaluronic acid production ■ We also offer a cosmetic ingredient "IMMUNOL-CO." For more details, please refer to the catalog or feel free to contact us.

• Organic Natural Materials

It is a plant-derived beauty ingredient fermented with natto bacteria from rice bran extract and soybean extract. It promotes the production of human type I collagen and hyaluronic acid in fibroblasts. 【Features】 ■ A plant-derived beauty ingredient comparable to placenta for anti-wrinkle and firmness improvement. ■ In human monitor tests, skin hydration and elasticity improvements have been confirmed, providing a noticeable effect on skin condition. (Patent No. 6332941) ■ Improves cardiovascular diseases, coldness, and swelling (improves blood flow and blood pressure). ■ Improves various symptoms of menopausal disorders (patent pending). ■ It has been shown to have a stronger acetaldehyde metabolism effect than curcumin, the active ingredient in turmeric, making it less likely to cause hangovers. ■ Maintains power during exercise (anti-fatigue effect). Effect of suppressing the accumulation of lactic acid, a fatigue substance, after exercise. Patent No. 5855375 ■ Reduces oxidative stress in the body. ■ Reduces triglycerides in blood vessels. ■ Available as a cosmetic ingredient. 【Explanation Video】 https://youtu.be/fv16LGEJjtY 【For General Consumers】 https://toyohakko-healthcare.com/celabio_f/

• Organic Natural Materials

"SENSEPUR" is a deodorizing material for bowel movements extracted through fermentation using biotechnology from plants and grains. It normalizes the intestinal flora, promotes intestinal movement, addresses constipation, positively affects the skin, normalizes nutrient absorption, and suppresses unpleasant odors through fermented extracts of rice bran and tree extracts (yucca extract, kiraya extract). Additionally, both yucca and kiraya contain a high amount of saponins, which are believed to exert direct deodorizing effects by capturing volatile oil-soluble components. 【Features】 ■ Suppression of odor intensity, odor concentration, and unpleasant odors ■ Refreshes the stomach and skin ■ Etiquette material for bad breath, body odor, and bowel odor ■ Good stability, can be blended in various forms ■ Balances intestinal flora 【Consumer Ingredient Introduction Page】 https://toyohakko-healthcare.com/sensepur/ *For more details, please refer to the catalog or feel free to contact us.

• Organic Natural Materials

"SOLWEED" is a health food made by mixing and extracting "mekabu" and the Canadian seaweed "ascophyllum," which is then spray-dried as is. Mekabu and ascophyllum contain useful minerals and are known for their blood coagulation prevention effects, cholesterol-lowering effects, as well as immune activation and anti-tumor effects due to components like fucoidan. This product has excellent heat stability, making it ideal for drinks that require heat sterilization and for high-temperature sterilized retort processing. 【Features】 ■ Excellent heat stability ■ Blood coagulation prevention effects, cholesterol-lowering effects ■ Immune activation and anti-tumor effects due to components like fucoidan ■ Inhibition of Salmonella binding to macrophages ■ Suppression of Helicobacter pylori proliferation For more details, please refer to the catalog or feel free to contact us.

• Organic Natural Materials

"YUKIME" is a fermented liquid made from sprouted brown rice grown without pesticides, using yeast for fermentation. It features not only moisture retention and penetration capabilities but also includes unique ingredients such as pesticide-free Yuki Hikari brown rice and Laccase yeast. By utilizing these attractive qualities, we can create a skincare product line focused on moisturizing. 【Features】 ■ Mild aging fermentation ■ Improves the skin's inherent strength from within ■ Enables a brand strategy specialized in moisturizing ■ Rich variety of formulations ■ Trademark logo mark available to guide to the YUKIME special site For features of YUKIME, benefits of incorporating YUKIME, examples of formulated cosmetics, and explanatory videos, visit here: https://www.toyohakko.com/products/yukime/

• others

"UNIFINE-CO" is a fermented isoflavone anti-glycation material that converts soybean-derived isoflavones into hydroxyl isoflavones through fermentation. By fermenting with koji mold, its functionality is enhanced, making it ideal for product planning aimed at anti-aging. We also offer food-grade raw material "UNIFINE." 【Features】 - Fermented material made from soybean extract containing isoflavones, fermented with koji mold - Anti-glycation material with hydroxyl isoflavones as the active ingredient (Patent No. 5318339) - Confirmed suppression of the production of glycation reaction products (CML, 3DG, pentosidine) - Confirmed degradation effect on anti-glycation products - Preventive effect against sagging caused by collagen glycation - Suppression of skin browning due to glycation - Suppression of the generation of carbonyl proteins, which are considered a cause of yellowing - Antioxidant ability (DPPH, OH radical scavenging ability) - Tyrosinase inhibition, collagenase inhibition For more details, please refer to the catalog or feel free to contact us.

• Organic Natural Materials

"CELABIO" is a highly safe plant-based material made from soybean extract and rice bran fermented with natto bacteria. 【Features】 ■ Highly safe plant-based natural material ■ Excellent cell activation effect (Patent No. 3625501) ■ Promotion of collagen production ■ Promotion of hyaluronic acid synthesis ■ Confirmed anti-wrinkle effect (number and volume of wrinkles, skin elasticity) in human trials (conducted by an external testing organization) ■ Confirmed improvement effect on skin condition at dermatology clinics ■ Synergistic effects confirmed when used in combination with other materials. Synergistic effect with retinol (Patent No. 4945556) Synergistic effect with soybean peptides and silk peptides (Patent No. 4945692) For more details, please refer to the catalog or feel free to contact us.

• Organic Natural Materials

"IMMUNOL-CO (for cosmetics)" is a material fermented using plant-derived ingredients from acetic acid bacteria isolated from fruit (persimmon). 【Features】 ■ Activates natural immunity ■ Suppresses allergy symptoms through immune activation ■ Promotes skin turnover by activating immunity ■ Activates macrophages, which are phagocytic cells ■ By activating fibroblasts and promoting the production of hyaluronic acid, it is thought to help maintain skin moisture and barrier function. ■ A food-grade ingredient "IMMUNOL" is also available. For more details, please refer to the catalog or feel free to contact us.

• Organic Natural Materials

This is an original patented ingredient fermented with lactic acid bacteria derived from Danish cheese, using rose petal extract. It has beauty effects such as whitening action, prevention of skin aging due to UV rays, and antioxidant effects. 【Features】 ● It is a patented material (Patent No. 5274525) that is expected to have a whitening effect by inhibiting the production of melanin through the inhibition of tyrosinase. ● It suppresses the production of carbonyl proteins, which are considered a cause of "yellowing." ● Antioxidant effects (DPPH, OH radical scavenging ability) and the ability to reduce skin cell damage caused by reactive oxygen species have been confirmed. ● It has been confirmed to suppress skin cell damage and collagen destruction caused by UV irradiation. ● Other skin-beautifying effects such as collagenase inhibition, hyaluronidase inhibition, and elastase inhibition have been confirmed. For examples of cosmetics containing LACTIBIO ROSE, which has a natural origin index of over 95%, click here: https://www.toyohakko.com/products/hakko_rose/

• Organic Natural Materials

"ROSE CRYSTA-CO" (Rose Extract) is a functional cosmetic ingredient for comprehensive beauty, extracted and refined from rose petals using hot water. It prevents wrinkles by inhibiting the enzyme "hyaluronidase," maintains firm skin, and suppresses skin inflammation caused by sunburn and other factors. We have confirmed its antibacterial effect against acne-causing bacteria and its antioxidant properties that address various skin troubles. [Features] - Firmness and moisture effect on the skin (hyaluronidase inhibition activity) - Sunscreen effect for the skin (UV protection effect from polyphenols) - Suppression of acne bacteria proliferation - Prevention of skin oxidation (antioxidant effect) - Tested on humans with patch tests - Listed in the standards for quasi-drugs For more details, please refer to the catalog or feel free to contact us.

• Organic Natural Materials