Skin fermentation extract "Skin Koji Water" that regulates skin metabolism.

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last updated：Jan 26, 2024

東洋発酵

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It regulates skin metabolism and supports skin renewal.

- It is a material extracted from six carefully selected strains of koji mold (Aspergillus oryzae, Aspergillus luchuensis). - It contains over 200 beauty ingredients, including 20 types of amino acids and B vitamins. - It promotes the mRNA expression of profilaggrin, which is the precursor of NMF (Natural Moisturizing Factor). - It enhances the mRNA expression of hyaluronic acid synthase (HAS3) in epidermal keratinocytes. - It increases the mRNA expression of Kallikrein-7 (KLK7), which promotes the shedding of corneocytes during turnover. - It promotes skin turnover through the ATP production enhancement effect in epidermal keratinocytes. - It stimulates collagen production in fibroblasts. - The promoting effect on turnover in humans has been confirmed. - In a continuous use trial of skin koji water cosmetics in humans, improvements in stratum corneum moisture content, increased KLK7 activity, reduced stratum corneum shedding, as well as reductions in wrinkles, enhanced skin brightness, and increased skin elasticity were confirmed. Features of skin koji water, examples of cosmetic concepts, and examples of developed products. https://www.toyohakko.com/products/hadakojisui/

Related Link - https://www.toyohakko.com/material/hadakojisui/

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【Safety Test Data】 Concentration: Aspergillus culture ■ Ames test: Negative (Concentration: 200%) ■ Skin irritation test (alternative method OECD TG439): Non-irritating (Concentration: 200%) ■ Eye irritation test (alternative method OECD TG492): Non-irritating (Concentration: 200%) ■ Phototoxicity test (alternative method OECD TG495): Negative (Concentration: 200%) ■ Human patch test (24-hour occlusion, 20 subjects): Safe product (Concentration: 200%) ■ Human skin sensitization test (RIPT, 50 subjects): No cumulative irritation or sensitization (Concentration: 200%)