イナリサーチ List of Products and Services

Inari Research supports toxicity testing from the screening stage to the entry into clinical trials (clinical studies). We propose test designs tailored to the regulations and drugs of each country. 【Immediate Hypersensitivity Tests】 ■ Active Systemic Anaphylaxis Test (ASA Test) ■ Passive Cutaneous Anaphylaxis Test (PCA Test) ■ Heterologous Passive Cutaneous Anaphylaxis Test (Hetero-PCA Test) 【Delayed-Type Hypersensitivity Tests】 ■ DTH Skin Reaction Test ■ Popliteal Lymph Node Test (PLNA Test) ■ Skin Sensitization Tests - Maximization Method, Adjuvant and Patch Method, Buehler Method, etc. - Local Lymph Node Assay (LLNA Method) ■ Skin Phototoxicity Test *For more details, please refer to the PDF materials or feel free to contact us.

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We conduct searches for the dependence of drugs with central nervous system effects. From screening various drugs to application testing, we can perform tests tailored to your needs. We carry out highly accurate tests in accordance with domestic and international regulations and guidelines. Based on years of experience and achievements, we also offer consultations and consulting services regarding drug dependence in pharmaceutical development. 【Drug Self-Administration Experiments】 ■ Search for the presence or absence of reinforcing effects of test drugs and the central nervous system effects that manifest at self-administered doses. - Drug self-administration experimental methods via intravenous or gastric routes in macaques. - Intravenous self-administration experimental methods in rats. *For more details, please refer to the PDF materials or feel free to contact us.

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We conduct searches for the dependence of drugs with central nervous system effects. We can perform tests tailored to your needs, from screening various drugs to application tests. We carry out highly accurate tests in accordance with domestic and international regulations and guidelines. Based on years of experience and achievements, we also offer consultations and consulting services regarding dependence in pharmaceutical development. 【Drug Discrimination Tests】 ■ We search to see if the changes in internal sensations caused by the drug (discriminative stimulus effects) are similar to those of known representative addictive drugs (generalization). - Drug discrimination tests using macaques - Drug discrimination tests using rats *For more details, please refer to the PDF materials or feel free to contact us.

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We conduct searches for the dependence of drugs with central nervous system effects. From screening various drugs to application testing, we offer tests tailored to your needs. We carry out highly accurate tests in accordance with domestic and international regulations and guidelines. Based on years of experience and achievements, we also provide consultations and consulting services regarding dependence in pharmaceutical development. 【Conditioned Place Preference Test (CPP)】 ■ By conditioning changes in internal sensations during drug administration to the environment, we detect the preference for the drug (reward effect). ■ Conducted simply and quickly using rats. ■ Suitable for basic research on psychological dependence. *For more details, please refer to the PDF materials or feel free to contact us.

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We conduct searches for the dependence of drugs with central nervous system effects. From screening various drugs to application tests, we can perform tests tailored to your needs. We carry out highly accurate tests in accordance with domestic and international regulations and guidelines. Based on years of experience and achievements, we also offer consultations and consulting services regarding dependence in pharmaceutical development. 【Physical Dependence Formation Test】 ■ After repeated administration of the test substance, a withdrawal period is observed to check for the presence and intensity of withdrawal symptoms, thereby searching for the potential for physical dependence formation. - Physical dependence formation test using macaques - Physical dependence formation test using rats *For more details, please refer to the PDF materials or feel free to contact us.

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We will examine and establish measurement methods used in safety tests (TK) and pharmacokinetic tests (PK). Translation of measurement methods conducted at other facilities is also possible. 【Examination and Establishment of New Analytical Methods】 ■ Target: Test substances and their metabolites in biological samples such as blood, urine, feces, and tissue homogenates ■ Methods: Protein precipitation, solid-phase extraction, liquid-liquid extraction, etc. ■ Measurement conditions: LC-MS/MS and HPLC, etc. *For more details, please refer to the PDF document or feel free to contact us.

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Prior to safety tests (TK) and pharmacokinetic tests (PK), we conduct analytical method validation in accordance with domestic and international guidelines. We propose appropriate validation items ranging from simple validation to full validation. We can also accommodate various regulations (reliability standards, GLP standards). 【Analytical Method Validation】 ■ Target: Measurement of test substances and their metabolites in biological samples such as blood, urine, feces, and tissue homogenates ■ Methods: Protein precipitation, solid-phase extraction, liquid-liquid extraction, etc. ■ Measurement conditions: LC-MS/MS and HPLC, etc. *For more details, please refer to the PDF materials or feel free to contact us.

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At Inari Research, we measure and analyze the concentrations of test substances and metabolites in biological samples obtained through safety tests (TK) and pharmacokinetic tests (PK). GLP compliance is possible. We also have extensive analysis experience in multi-site studies. We conduct ISR (Incurred Sample Reanalysis) in accordance with guidelines. If you provide kits or antibodies, we can also perform measurements using immunoassay methods. 【Concentration Measurement in Biological Samples】 ■ Targets: Measurement of test substances and their metabolites in biological samples such as blood, urine, feces, and tissue homogenates. ■ Methods: Protein precipitation, solid-phase extraction, liquid-liquid extraction, etc. ■ Measurement Conditions: LC-MS/MS and HPLC, etc. *For more details, please refer to the PDF document or feel free to contact us.

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At Inari Research, we conduct analyses of test substances and dosing solutions used in safety testing. GLP-compliant implementation is possible. We also have a track record of analyses in multi-site studies. 【Analysis of Test Substances】 ■ Method validation ■ Concentration verification, uniformity, stability, and characterization analysis 【Regarding Concentration Verification, Uniformity, Stability, and Characterization Analysis】 ■ Concentration verification and stability/uniformity testing of dosing solutions - Using HPLC, spectrophotometers, ELISA kits, etc. ■ Characterization analysis and stability of test substances (active ingredients and formulations) - Using HPLC, TLC, spectrophotometers, pH meters, Karl Fischer moisture meters, osmotic pressure meters, etc. *For more details, please refer to the PDF document or feel free to contact us.

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Inari Research supports toxicity testing necessary for new chemical substance registration applications from the screening stage. We conduct tests using standard test species such as mice, rats, rabbits, dogs, and primates, as well as alternative methods using cultured cells, which have been increasingly required both domestically and internationally in recent years. Our company is a GLP-compliant facility and has obtained certification from AAALAC International (the Association for Assessment and Accreditation of Laboratory Animal Care International). We conduct in vivo/in vitro tests that comply with regulations related to the review and manufacturing of chemical substances (Chemical Substances Control Law) and the Labor Safety and Health Law (Safety and Health Law), as well as regulations concerning new chemical substance applications in various countries. Additionally, we offer consulting on toxicity evaluation based on the regulations of each country. [General Toxicity Testing] - We handle tests from acute toxicity to subchronic and chronic toxicity testing. - The test supervisor communicates with clients while conducting the tests. - Various necessary inspections and their evaluations are supported by experienced researchers and technicians. *For more details, please refer to the PDF materials or feel free to contact us.

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Inari Research supports toxicity testing necessary for the registration of new chemical substances from the screening stage. We conduct tests using standard test subjects such as mice, rats, rabbits, dogs, and primates, as well as alternative methods using cultured cells, which have been increasingly required both domestically and internationally in recent years. Our company is a GLP-compliant facility and has obtained certification from AAALAC International (the Association for Assessment and Accreditation of Laboratory Animal Care International). We conduct in vivo/in vitro tests that comply with regulations related to the review and manufacturing of chemical substances (Chemical Substances Control Law) and the Occupational Safety and Health Act, as well as regulations concerning new chemical substance applications in various countries. Additionally, we offer consulting services regarding toxicity evaluation based on the regulations of each country. 【Genotoxicity Tests】 ■ Bacterial reverse mutation test (Ames test) using cells ■ Mammalian bone marrow chromosome aberration test (rats) ■ Micronucleus test using mice and rats (bone marrow, peripheral blood, liver) and blood exposure certification tests are also possible ■ Chromosome aberration test using mammalian cultured cells/human lymphocytes *For more details, please refer to the PDF materials or feel free to contact us.

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Inari Research supports toxicity testing necessary for the registration of new chemical substances from the screening stage. We conduct tests using standard test subjects such as mice, rats, rabbits, dogs, and primates, as well as alternative methods using cultured cells, which have been increasingly required both domestically and internationally in recent years. Our company is a GLP-compliant facility and has obtained certification from AAALAC International (the Association for Assessment and Accreditation of Laboratory Animal Care International). We conduct in vivo/in vitro tests that comply with regulations related to the review and manufacturing of chemical substances (Chemical Substances Control Law) and the Industrial Safety and Health Act, as well as regulations concerning new chemical substance applications in various countries. Additionally, we offer consulting services regarding toxicity evaluations based on the regulations of different countries. 【Phototoxicity Testing】 ■ 3T3 Cells ■ Compliant with OECD Test Guidelines *For more details, please refer to the PDF materials or feel free to contact us.

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Inari Research supports toxicity testing necessary for the registration of new chemical substances from the screening stage. We conduct tests using standard test species such as mice, rats, rabbits, dogs, and monkeys, as well as alternative methods using cultured cells, which have been increasingly required both domestically and internationally in recent years. Our company is a GLP-compliant facility and has obtained certification from AAALAC International (the Association for Assessment and Accreditation of Laboratory Animal Care International). We conduct in vivo/in vitro tests that comply with regulations related to the review and manufacturing of chemical substances (Chemical Substances Control Law) and the Occupational Safety and Health Law, as well as regulations concerning new chemical substance applications in various countries. Additionally, we offer consulting services regarding toxicity evaluations based on the regulations of each country. 【Reproductive and Developmental Toxicity Testing】 ■ Teratogenicity Tests (Mice, Rats, Rabbits) ■ Reproductive Toxicity Tests (Rats) ■ Reproductive/Developmental Toxicity Screening Tests (Rats) ■ Combined Tests of Repeated Dose Toxicity and Reproductive Developmental Toxicity Screening Tests (Rats) *For more details, please refer to the PDF materials or feel free to contact us.

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Inari Research supports toxicity testing necessary for the registration of new chemical substances from the screening stage. We conduct tests using standard test subjects such as mice, rats, rabbits, dogs, and monkeys, as well as alternative methods using cultured cells, which have been increasingly required both domestically and internationally in recent years. Our company is a GLP-compliant facility and has obtained certification from AAALAC International (the Association for Assessment and Accreditation of Laboratory Animal Care International). We conduct in vivo/in vitro tests that comply with regulations related to the examination and manufacturing of chemical substances (Chemical Substances Control Law) and the Occupational Safety and Health Law, as well as regulations concerning new chemical substance applications in various countries. Additionally, we offer consulting services regarding toxicity assessments based on the regulations of each country. 【Carcinogenicity Testing】 ■ Long-term carcinogenicity tests using mice and rats (preliminary tests, main tests) - Can be conducted via oral (forced, mixed feed), dermal, or subcutaneous routes of administration. ■ Short-term carcinogenicity tests - Short-term carcinogenicity tests using genetically modified mice are also possible. *For more details, please refer to the PDF materials or feel free to contact us.

• Contract Inspection

Inari Research supports toxicity testing necessary for the registration of new chemical substances from the screening stage. We conduct tests using standard test subjects such as mice, rats, rabbits, dogs, and primates, as well as alternative methods using cultured cells, which have been increasingly required both domestically and internationally in recent years. Our company is a GLP-compliant facility and has obtained certification from AAALAC International (the Association for Assessment and Accreditation of Laboratory Animal Care International). We conduct in vivo/in vitro tests that comply with regulations related to the review and manufacturing of chemical substances (Chemical Substances Control Law) and the Industrial Safety and Health Act, as well as regulations concerning new chemical substance applications in various countries. Additionally, we offer consulting services regarding toxicity evaluations based on the regulations of each country. 【Irritation Tests】 ■ Evaluation of corrosiveness and irritancy using rabbits - Acute dermal irritation/corrosion test - Acute ocular irritation/corrosion test ■ In vitro tests using cultured cells as an alternative method - In vitro skin irritation test - In vitro eye irritation test *For more details, please refer to the PDF materials or feel free to contact us.

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Inari Research supports toxicity testing necessary for the registration of new chemical substances from the screening stage. We conduct tests using standard test subjects such as mice, rats, rabbits, dogs, and monkeys, as well as alternative methods using cultured cells, which have been increasingly required both domestically and internationally in recent years. Our company is a GLP-compliant facility and has obtained certification from AAALAC International (Association for Assessment and Accreditation of Laboratory Animal Care International). We conduct in vivo/in vitro tests that comply with regulations related to the review and manufacturing of chemical substances (Chemical Substances Control Law) and the Labor Safety and Health Law, as well as regulations concerning new chemical substance applications in various countries. Additionally, we offer consulting services regarding toxicity evaluations based on the regulations of different countries. 【Skin Sensitization Tests】 ■ Skin Sensitization Tests (Guinea Pig) - Maximization Method - Buehler Method ■ Skin Sensitization: Local Lymph Node Assay (Mouse) - LLNA Method (BrdU-FC) *For more details, please refer to the PDF document or feel free to contact us.

• Contract Inspection

We support the toxicity tests required for the registration application of new pesticides and formulations from the screening stage. We conduct tests using standard test subjects such as mice, rats, rabbits, dogs, and primates, as well as alternative methods using cultured cells, which have been increasingly requested both domestically and internationally in recent years. Inari Research is a GLP-compliant facility and has obtained certification from AAALAC International (the Association for Assessment and Accreditation of Laboratory Animal Care International). We conduct in vivo/in vitro tests in accordance with the regulations related to new pesticide applications and safety evaluations of pesticide formulations in various countries, as well as OECD guidelines. Additionally, we offer consulting on toxicity evaluations based on the regulations of each country. 【General Toxicity Tests】 - Conduct acute toxicity tests, as well as subchronic and chronic toxicity tests. - The test supervisor communicates with clients while conducting the tests. - Various necessary examinations and their evaluations are supported by experienced researchers and technicians. *For more details, please refer to the PDF document or feel free to contact us.

• Contract Inspection

We support the toxicity tests required for new pesticide and formulation registration applications from the screening stage. We conduct tests using standard test subjects such as mice, rats, rabbits, dogs, and primates, as well as alternative methods using cultured cells that are increasingly demanded both domestically and internationally. Inari Research is a GLP-compliant facility and has obtained certification from AAALAC International (the Association for Assessment and Accreditation of Laboratory Animal Care International). We conduct in vivo/in vitro tests that comply with regulations related to new pesticide applications and safety evaluations of pesticide formulations in various countries, as well as OECD guidelines. Additionally, we offer consulting on toxicity evaluations based on the regulations of each country. 【Genotoxicity Tests】 ■ Bacterial reverse mutation test (Ames test) using cells ■ Chromosomal aberration test using mammalian cultured cells/human lymphocytes ■ Micronucleus test using mice and rats (bone marrow, peripheral blood, liver) *Blood exposure proof tests can also be conducted ■ Mammalian bone marrow chromosomal aberration test (rat) *For more details, please refer to the PDF materials or feel free to contact us.

• Contract Inspection

We support the toxicity tests required for new pesticide and formulation registration applications from the screening stage. We conduct tests using standard test subjects such as mice, rats, rabbits, dogs, and primates, as well as alternative methods using cultured cells that are increasingly required both domestically and internationally. Inari Research is a GLP-compliant facility and has obtained certification from AAALAC International (the Association for Assessment and Accreditation of Laboratory Animal Care International). We conduct in vivo/in vitro tests in accordance with the regulations related to new pesticide applications and safety evaluations of pesticide formulations in various countries, as well as OECD guidelines. Additionally, we offer consulting on toxicity evaluations based on the regulations of each country. 【Reproductive and Developmental Toxicity Tests】 ■ Teratogenicity tests (mice, rats, rabbits) ■ Reproductive toxicity tests (rats) ■ Reproductive/developmental toxicity screening tests (rats) ■ Combined tests of repeated dose toxicity tests and reproductive developmental toxicity screening tests (rats) *For more details, please refer to the PDF materials or feel free to contact us.

• Contract Inspection

We support the toxicity tests required for new pesticide and formulation registration applications from the screening stage. We conduct tests using standard test subjects such as mice, rats, rabbits, dogs, and primates, as well as alternative methods using cultured cells that have been increasingly requested both domestically and internationally in recent years. Inari Research is a GLP-compliant facility and has obtained certification from AAALAC International (the Association for Assessment and Accreditation of Laboratory Animal Care International). We conduct in vivo/in vitro tests in accordance with regulations related to new pesticide applications and safety evaluations of pesticide formulations in various countries, as well as OECD guidelines. Additionally, we offer consulting services regarding toxicity evaluations based on the regulations of each country. 【Carcinogenicity Tests】 ■ Long-term carcinogenicity tests using mice and rats (preliminary tests, main tests) - Can be conducted via oral (forced, mixed feed), dermal, subcutaneous, and other routes of administration. ■ Short-term carcinogenicity tests - Short-term carcinogenicity tests using genetically modified mice are also possible. *For more details, please refer to the PDF materials or feel free to contact us.

• Contract Inspection

We support the toxicity tests required for new pesticide and formulation registration applications from the screening stage. We conduct tests using standard test subjects such as mice, rats, rabbits, dogs, and primates, as well as alternative methods using cultured cells that are increasingly required both domestically and internationally. Inari Research is a GLP-compliant facility and has obtained certification from AAALAC International (the Association for Assessment and Accreditation of Laboratory Animal Care International). We conduct in vivo/in vitro tests in accordance with regulations related to new pesticide applications and safety assessments of pesticide formulations in various countries, as well as OECD guidelines. Additionally, we offer consulting services regarding toxicity assessments based on the regulations of each country. 【Irritation Tests】 ■ Evaluation of corrosiveness and irritability using rabbits - Acute dermal irritation/corrosiveness test - Acute ocular irritation/corrosiveness test ■ In vitro tests using cultured cells as alternative methods are also available - In vitro dermal irritation test - In vitro ocular irritation test *For more details, please refer to the PDF materials or feel free to contact us.

• Contract Inspection

We support the toxicity tests required for new pesticide and formulation registration applications from the screening stage. We conduct tests using standard test subjects such as mice, rats, rabbits, dogs, and primates, as well as alternative methods using cultured cells, which have been increasingly demanded both domestically and internationally in recent years. Inari Research is a GLP-compliant facility and has obtained certification from AAALAC International (the Association for Assessment and Accreditation of Laboratory Animal Care International). We conduct in vivo/in vitro tests that comply with regulations related to new pesticide applications and safety assessments of pesticide formulations in various countries, as well as OECD guidelines. Additionally, we offer consulting services regarding toxicity assessments based on the regulations of each country. 【Skin Sensitization Tests】 ■ Skin Sensitization Test (Guinea Pig) - Maximization Method - Buehler Method ■ Skin Sensitization: Local Lymph Node Assay (Mouse) - LLNA Method (BrdU-FC) *For more details, please refer to the PDF materials or feel free to contact us.

• Contract Inspection

We support the toxicity tests required for new pesticide and formulation registration applications from the screening stage. We conduct tests using standard test subjects such as mice, rats, rabbits, dogs, and primates, as well as alternative method tests using cultured cells that are increasingly required both domestically and internationally. Inari Research is a GLP-compliant facility and has obtained certification from AAALAC International (Association for Assessment and Accreditation of Laboratory Animal Care International). We conduct in vivo/in vitro tests in accordance with regulations related to new pesticide applications and safety evaluations of pesticide formulations in various countries, as well as OECD guidelines. Additionally, we offer consulting services regarding toxicity evaluations based on the regulations of each country. 【Safety Tests for Pesticide Formulations】 ■ Acute Oral Toxicity Test (Mice, Rats) ■ Acute Dermal Toxicity Test (Mice, Rats) ■ Skin Irritation Test (Rabbits) ■ Eye Irritation Test (Rabbits) ■ Skin Sensitization Test (Mice, Guinea Pigs) *For more details, please refer to the PDF materials or feel free to contact us.

• Contract Inspection

Equipped with various analytical instruments, we are capable of conducting extensive inspections. Experienced clinical laboratory technicians perform the testing operations, and we have a system in place that allows for the following tests to be conducted at all times. 【Clinical Test Contents】 ■ Blood cell counts (red blood cell count, white blood cell count, platelet count, hemoglobin level, hematocrit value) and simultaneous measurement of white blood cell differential classification (ratio and actual numbers) and reticulocyte count using hematology testing equipment. ■ Reticulocyte count using ultra-biological staining specimens and calculation of white blood cell differential classification (ratio) using smear staining specimens, as well as blood smear observation are also possible. *For more details, please refer to the PDF document or feel free to contact us.

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Equipped with various analytical instruments, we are capable of conducting extensive inspections. Experienced clinical laboratory technicians carry out the testing operations, and we have a system in place to continuously perform the following tests. 【Clinical Test Details】 ■ Measurement of prothrombin time, fibrinogen levels, activated partial thromboplastin time, and coagulation factor activity using a blood coagulation measurement device ■ Measurement of D-dimer and others ■ Measurement of platelet aggregation ability using a platelet aggregation measurement device *For more details, please refer to the PDF document or feel free to contact us.

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Equipped with various analytical instruments, we are capable of conducting a wide range of tests. Experienced clinical laboratory technicians carry out the testing operations, and we are always prepared to perform the following tests: 【Clinical Test Details】 ■ Measurement of nucleated cell counts in the femur of rats, and the ribs of dogs and monkeys ■ Calculation of bone marrow cell fractions (ratios) using bone marrow smear samples *For more details, please refer to the PDF document or feel free to contact us.

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Equipped with various analytical instruments, we are capable of conducting extensive inspections. Experienced clinical laboratory technicians carry out the testing operations, and we have a system in place that allows us to perform the following tests at all times. 【Clinical Test Contents】 ■ Quantification of proteins, enzymes, low molecular nitrogen compounds, carbohydrates, lipids, electrolytes, pigments, etc., using biochemical automatic analyzers. *For more details, please refer to the PDF document or feel free to contact us.

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Equipped with various analytical instruments, we are capable of conducting a wide range of tests. Experienced clinical laboratory technicians carry out the testing operations, and we have a system in place that allows us to perform the following tests at all times. 【Clinical Test Details】 ■ Measurement of protein fractions and CK isoenzymes using agarose gel electrophoresis with an automatic electrophoresis device. *For more details, please refer to the PDF document or feel free to contact us.

• Contract Inspection

Equipped with various analytical instruments, a wide range of inspections is possible. Experienced clinical laboratory technicians conduct the testing operations, and we have a system in place that allows for the following tests to be performed at all times. 【Clinical Testing Details】 ■ Various tests using commercially available ELISA kits (Troponin I, Kim-1, etc.) *For more details, please refer to the PDF document or feel free to contact us.

• Contract Inspection

Equipped with various analytical instruments, we are capable of conducting a wide range of tests. Experienced clinical laboratory technicians carry out the testing operations, and we are always prepared to perform the following tests: 【Clinical Test Contents】 ■ Various tests using commercially available ELISA kits (OC, PYD, DPD, NTX, CTX, etc.) *For more details, please refer to the PDF document or feel free to contact us.

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Equipped with various analytical instruments, we are capable of conducting a wide range of tests. Experienced clinical laboratory technicians carry out the testing operations, and we have a system in place that allows us to perform the following tests at all times. 【Clinical Test Details】 ■ Measurement of lymphocyte subsets (T cells [CD4, CD8], B cells, NK cells) using a flow cytometer. *For more details, please refer to the PDF document or feel free to contact us.

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Equipped with various analytical instruments, we are capable of conducting a wide range of tests. Experienced clinical laboratory technicians carry out the testing operations, and we are always prepared to perform the following tests: 【Clinical Test Details】 ■ Blood gas analysis (pH, O2, CO2) using a blood gas analyzer *For more details, please refer to the PDF document or feel free to contact us.

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Equipped with various analytical instruments, we are capable of conducting a wide range of tests. Experienced clinical laboratory technicians carry out the testing operations, and we have a system in place to perform the following tests at all times. 【Clinical Test Contents】 ■ Measurement of urine volume, color observation, specific gravity measurement, osmotic pressure measurement, qualitative and semi-quantitative tests using test strips, quantification of electrolytes in urine, etc. ■ Quantification of various urinary components such as protein and NAG. *For more details, please refer to the PDF document or feel free to contact us.

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Equipped with various analytical instruments, we are capable of conducting a wide range of tests. Experienced clinical laboratory technicians carry out the testing operations, and we have a system in place to perform the following tests at all times. 【Clinical Test Contents】 ■ Stool Tests ■ Hemolytic Tests ■ Blood and Organ Sampling ■ Sampling *For more details, please refer to the PDF document or feel free to contact us.

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Inari Research's necropsy and specimen preparation are conducted by technicians with over 10 years of practical experience and extensive training. Pathological histological examinations are carried out by qualified professionals, including certified toxicologic pathologists, certified veterinary pathologists, and certified toxicologists, who also perform toxicological assessments. Additionally, we hold regular pathology conferences involving our pathology consultants. 【Pathological Examination Contents】 ■Specimen Preparation - Light microscopy specimens (including routine preparation of organs, continuous sections, and large brain sections) - Specimen preparation for electron microscopy (TEM) - Frozen section specimen preparation (cryostat) - Special stains (PAS stain, PAM stain, iron stain, Masson's trichrome stain, azan stain, elastica van Gieson stain, fat stain, etc.) - Immunohistochemical staining (Ki67, PCNA, Desmin, CD31, CD45, Nephrin, WT-1, α-SMA, LAMP-2, etc.) *For more details, please refer to the PDF document or feel free to contact us.

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Inari Research's necropsy and specimen preparation are carried out by technicians with over 10 years of practical experience and thorough training. Pathological histological examinations are conducted by qualified professionals, including certified toxicologic pathologists, certified veterinary pathologists, and certified toxicologists, who also perform toxicity assessments. Additionally, regular pathology conferences involving our pathology advisors are held. [Pathology Examination Contents] ■ Examinations using optical and electron microscopy - General toxicity tests - Carcinogenicity tests - Special toxicity tests (such as irritation tests) - Pharmacological efficacy tests - Pathological models (such as arthritis and nephritis) - Image analysis (such as anti-tumor and efficacy evaluations) *For more details, please refer to the PDF document or feel free to contact us.

• Contract Inspection

Inari Research's necropsy and specimen preparation are conducted by technicians with over 10 years of practical experience and extensive training. Pathological histological examinations are carried out by qualified professionals, including certified toxicologic pathologists, certified veterinary pathologists, and certified toxicologists, who also perform toxicological assessments. Additionally, we hold regular pathology conferences involving our pathology advisors. [Response to Peer Review] - Collaboration with designated peer review institutions - We can introduce reliable and reputable peer review facilities (e.g., Lunapas Toxicologic Pathology Institute) - Our pathologists can serve as reviewers for tests conducted at other facilities for peer review - In accordance with regulations, we implement documentation in study protocols and maintain related materials *For more details, please refer to the PDF materials or feel free to contact us.*

• Contract Inspection

Inari Research Co., Ltd. is a company that develops support services for the development of pharmaceuticals and other products, as well as engaging in environmental business. We utilize the know-how cultivated through the operation of experimental animal facilities to design and sell animal experiments, chemical experiments, and related facility design and construction, as well as air conditioning systems suitable for the same room, air purification equipment, and wastewater treatment facilities. We also handle various experimental instruments and equipment, as well as engineering services, and have a wide range of delivery achievements in industries such as pharmaceutical companies, public research institutions, universities, non-clinical trial contract organizations, hospitals, semiconductor factories, food factories, and livestock-related companies, along with environmental-related products. [Business Activities] ■ Non-clinical trial business ■ Clinical trial business ■ Environmental business For more details, please refer to our catalog or feel free to contact us.

• Other environmental equipment

The "INA NOTES July 2016 Special Edition" is a publication by Inari Research Co., Ltd., which engages in the installation and sale of air conditioning systems, scrubbers (gas removal devices), breeding equipment, experimental instruments, and more. This publication introduces the events of the 43rd Annual Meeting of the Japanese Society of Toxicology SEND Symposium, as well as an overview of the presentations by the Inari Research SEND team at the JSOT SEND Symposium. [Contents] ■ 43rd Annual Meeting of the Japanese Society of Toxicology SEND Symposium ■ Three days that began and ended with SEND ■ General presentations related to SEND (posters) ■ JSOT Inari Research Science Evening ■ Information on SEND seminars sponsored and co-hosted by Inari Research ■ Inari Research's SEND support services *The downloadable version is a "digest edition." If you would like the "full edition," please feel free to contact us.

• Testing Equipment and Devices

The "INA NOTES April 2015 First Issue" is a publication by Inari Research Co., Ltd., which conducts safety testing and pharmacological efficacy testing for the development of pharmaceuticals, medical devices, pesticides, food, and other chemical substances. This publication features a special section on the pharmaceutical development support alliance concept and initiatives related to the marmoset testing project, along with photographs. [Contents] ■ Introduction to INA NOTES ■ Milestones of the 40th Anniversary ■ Pharmaceutical Development Support Alliance Concept: Full-scale Launch ■ Initiatives for the Marmoset Testing Project ■ Recent Events *The downloadable version is a "digest edition." If you would like the "full edition," please feel free to contact us.

• Testing Equipment and Devices

"INA NOTES December 2015 No.2" is a publication by Inari Research Co., Ltd., which conducts safety testing and pharmacological efficacy testing for the development of pharmaceuticals, medical devices, pesticides, food, and other chemical substances. This publication includes a report on the response and background following the successful FDA SEND trial application, a participation report from the Japanese Society of Toxicology Annual Meeting, and information on the marmoset testing project, accompanied by photographs. [Contents] ■ HOT TOPIC Successful FDA SEND trial application ■ Participation report from the 42nd Japanese Society of Toxicology Annual Meeting ■ Marmoset testing project for small primates - Report No. 2 ■ Latest technology information *The downloadable version is a "digest version." If you would like the "full version," please feel free to contact us.

• Testing Equipment and Devices

"INA NOTES June 2016 No.3" is a publication by Inari Research Co., Ltd., which conducts safety testing and efficacy pharmacology testing for the development of pharmaceuticals, medical devices, pesticides, food, and other chemical substances. This publication includes a report on participation in the 15th Annual Meeting of the Japanese Society for Regenerative Medicine, as well as research presentation reports from the 7th Annual Meeting of the Japanese Society for Safety Research, and information on the marmoset testing project, accompanied by graphs and photographs. [Contents] ■ Efforts towards animal welfare and alternative methods ■ Participation report: 15th Annual Meeting of the Japanese Society for Regenerative Medicine ■ Research presentation report: 7th Annual Meeting of the Japanese Society for Safety Research ■ Marmoset testing project for small primates - Report No. 3 - ■ Recent events, etc. *The downloadable version is a "digest version." If you would like the "full version," please feel free to contact us.

• Testing Equipment and Devices

"INA NOTES December 2016 No.4" is a publication by Inari Research Co., Ltd., which conducts safety testing and pharmacological efficacy testing for the development of pharmaceuticals, medical devices, pesticides, food, and other chemical substances. This publication includes the latest technology information, a feature on drug dependence testing, and initiatives related to marmoset testing, presented with diagrams and photographs. [Contents] ■ SEND NEWS ■ Latest Technology Information ■ Feature: Drug Dependence Testing ■ Series: Initiatives in Marmoset Testing ■ TOPICS ■ Announcements *The downloadable version is a "Digest Edition." If you would like the "Complete Edition," please feel free to contact us.

• Testing Equipment and Devices

"INA NOTES December 2017 No.5" is a publication by Inari Research Co., Ltd., which conducts safety testing and pharmacological efficacy testing for the development of pharmaceuticals, medical devices, pesticides, food, and other chemical substances. This publication features the latest technological information, a special section on drug dependency testing, and initiatives related to the marmoset testing project, along with diagrams and photographs. [Contents] ■ SEND Reports: Initiatives for SEND by pathologists ■ Series: Initiatives of the marmoset testing project ■ Special Feature: AAALAC International Site visit and international trends in animal welfare ■ Conference participation report ■ TOPICS ■ Announcements *For more details, please refer to the PDF document or feel free to contact us.

• Testing Equipment and Devices