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The "RS Liposome 3.0 Complex" is a high-performance penetrating cosmetic ingredient that combines "RS Liposome 3.0," which is liposome-encapsulated human stem cell culture fluid RemyStem, with the penetrating peptide vitamin C derivative "Pentide-C." "Pentide-C" has been confirmed to suppress the secretion of the inflammatory marker "TNF-α" secreted by monocytes stimulated with LPS, demonstrating anti-inflammatory effects. Additionally, it has been confirmed that the exosomes from RemyStem, when pre-added to keratinocytes, suppress damage caused by H2O2 and enhance the cells' antioxidant effects. 【Features】 ■ A material combining RS Liposome 3.0 and Pentide-C ■ Double penetration of the penetrating peptide vitamin C derivative and functional materials ■ Promotion of collagen production in fibroblasts ■ Anti-inflammatory effects of Pentide-C and antioxidant effects of RemyStem ■ Whitening effects and suppression of melanin production *For more details, please refer to the PDF document or feel free to contact us.

"Pentide-C" is a stabilized vitamin C derivative that combines peptides with the hydroxyl group of vitamin C. Since vitamin C and peptides are linked by peptide bonds, after being taken up by cells, this bond undergoes hydrolysis by proteases. As a result, vitamin C becomes free, and data shows that its bioavailability is higher at low concentrations compared to pure vitamin C. [Features] ■ Penetration into the skin ■ Uptake by cells ■ Collagen production ■ Inhibition of melanin production ■ Antibacterial against Staphylococcus aureus *For more details, please refer to the PDF document or feel free to contact us.

Do you have any of these concerns? - With conventional vitamin C derivatives, the mechanism of penetration into the skin and the release of free vitamin C is unclear. - I am looking for ingredients that can effectively work even at low concentrations while minimizing irritation. Pentide-C solves these issues. 【Feature 1】High bioavailability and innovative mechanism It penetrates the cell membrane regardless of the expression of vitamin C transporters, and vitamin C is effectively utilized within the cells as the peptide bonds are cleaved by intracellular enzymes (peptidases). This high bioavailability has been recognized, winning a gold award in the technology category at CITE JAPAN 2021. 【Feature 2】Collagen production ability from low concentrations Due to its high cell permeability, it shows collagen synthesis induction activity in human fibroblasts from a low concentration of 0.08µM. This is due to its unique mechanism that allows vitamin C to become free quickly, independent of transporters. *For more details, please download the PDF or feel free to contact us.