ソフィオンバイオサイエンス List of Products and Services

Our company is jointly developing a new protocol that enables efficient screening studies to identify modulators of Kv7.2/Kv7.3 channel activity using spider venom peptides. This will advance the understanding of gain-of-function mutations in channel-related epilepsy and potential therapies. *For more details, please refer to the related links. Feel free to contact us for more information.*

One in three adults experiences chronic pain in their lives, and the effectiveness of treatments is limited, leading to a worsening opioid crisis. Understanding the balance between pain and chronic pain, as well as methods for pain treatment, is becoming increasingly important. Ion channels play a central role in both the physiological pain response and the pathophysiological changes underlying chronic pain. These specialized protein structures embedded in the cell membrane control the flow of ions such as sodium (Na+), potassium (K+), and calcium (Ca2+) across the cell membrane. The movement of these ions generates electrical signals that propagate along neurons and ultimately reach the brain, where they are recognized as pain. *For more detailed information, please refer to the related links. Feel free to contact us for further inquiries.*

The paper using QPatch Compact focuses on the study of the inhibition of the Nav1.8 ion channel by two new analgesic compounds, VX-150 and VX-548. The Nav1.8 channel is a major target in sensory neurons that detect pain and is extremely important for pain-related therapies. This research, conducted by a professor's laboratory at Harvard Medical School, utilized the QPatch Compact semi-automated patch clamp system to perform voltage clamp recordings and analyze the effects of these compounds on Nav1.8 sodium currents. *For more details, you can view the related links. Please feel free to contact us for more information.*

As summer comes to an end and the signs of autumn are felt, we bring you the quarterly overview from Sophion users. The third quarter has also been a very busy period for the Sophion platform in ion channel research. Many themes are covered, including Nav, Kv, Cav, ligand-gated ion channels, neurological diseases, cancer, infectious diseases, safety pharmacology, as well as toxins and antidotes, so you are sure to find something that catches your eye. From an excellent list of publications, we would like to highlight three particularly valuable and interesting developments. *For more details on the articles, please refer to the related links. Feel free to contact us for more information.*

The recipients of the Sophion research grant are utilizing the grant to conduct research on chemotherapy drugs targeting Nav1.7 currents, further deepening their studies on sodium channels and cancer by using Sophion's automated patch clamp system. They are an assistant professor at Istanbul Medipol University and are currently affiliated with our laboratory in Copenhagen, conducting research alongside senior researcher Kim Boddum. We had a discussion about the research and its objectives. *For more detailed information, please refer to the related links. Feel free to contact us for further inquiries.*