日本ビュッヒ List of Products and Services

Spray drying is an attractive continuous process that transforms liquids (solutions, emulsions, slurries, pastes, or melts) into micron-sized particles, allowing for adjustments in spray volume, shape, porosity, concentration, and chemical composition. It is widely used in fields such as materials, chemicals, food, and pharmaceuticals. Typical applications include: ■ Coatings (titania, alumina, zirconia, yttria coatings) ■ Advanced ceramics (such as new superconducting ceramics) ■ Toners and magnetic tapes ■ Inhalable dry powders ■ Nanoparticle drugs, among others. *For more details, please refer to the catalog or contact us.

What is needed for innovation is to realize a vision. Büchi has demonstrated this concept over the past few decades through innovative products in the field of evaporation and separation. As a result of the continuous development of experimental methods and technologies, we have been able to complete this revised edition of the "Laboratory Assistant." This book will help provide a broader and deeper understanding of widely used laboratory equipment such as rotary evaporators, vacuum pumps, and melting point measurement devices. All the equipment illustrated in this book is Büchi's products. Each chapter of this book is written using general expressions to apply as much as possible to products from other companies. We hope that readers will find the content of the "Laboratory Assistant" interesting and that it will help solve challenging issues in the laboratory. We encourage you to have this book at hand.

Products with groundbreaking features are emerging one after another, such as yogurt containing beneficial bacteria that reach the intestines, fabric softeners that release a stronger fragrance when moved, facial cleansers infused with anti-aging ingredients, and oral medications with long-lasting effects. The technology of "microencapsulation" plays a significant role in this development. The 'B-390/B-395 Pro' is a device that instantly produces uniform, spherical capsules ranging from 0.15 to 2 mm, using materials such as alginates, gelatin, and fats as membranes. Inside the capsules, various components such as enzymes, drugs, cells, microorganisms, flavors, fragrances, oils, and vitamins are encapsulated, allowing for efficient development research to control dissolution time and locations. It is used for adjusting the components and functions of pharmaceuticals, foods, cosmetics, and more. ★ Currently, we are offering a free explanation of encapsulation technology and a collection of application examples for various industries! 【Applications】 - <Pharmaceuticals> Drug delivery systems that deliver active ingredients to specific locations - <Food> Enhancing the value of food materials by mixing multiple components - <Biological Research> Cell transplantation through the encapsulation of animal cells - <Cosmetics> Encapsulation of odor components, etc.

The "B390/B395 Pro" is a encapsulation device that uses polymers such as gelatin, pectin, and alginates to create extremely small capsules ranging from 0.15 to 2 mm. The capsules can encapsulate various components such as enzymes, drugs, cells, microorganisms, flavors, aromas, oils, and vitamins, allowing for stabilization and protection of the ingredients. Through controlled release, it is also possible to manage the dissolution time and release points of the components. It can produce up to 6000 capsules per second and is used for adjusting the components and functions of pharmaceuticals, food, cosmetics, and more. 【Applications】 - <Pharmaceuticals> Drug delivery systems that deliver components to specific locations - <Food> Enhancing the value of food materials by mixing multiple components - <Biological Research> Cell transplantation through the encapsulation of animal cells - <Cosmetics> Encapsulation of fragrance components and more *For more details, please download the catalog or contact us.

ProxiMate is a newly developed near-infrared analyzer for rapid component analysis of food and feed. Its robust and compact design, along with an intuitive operation screen, makes it ideal for use in manufacturing environments. Additionally, it offers a wide range of application packages for component analysis of food and feed. ProxiMate enables the streamlining of production and the acceleration of quality control. 【Features】 ■ Analysis of diverse samples A rich selection of application packages is available. Complicated settings are unnecessary, allowing anyone to easily perform component analysis. ■ Exceptional durability ProxiMate is designed to function effectively even under the most severe conditions. Measurements are unaffected by fluctuations in temperature and humidity. With an IP66 protection rating, ProxiMate can withstand being sprayed with water using a pressure hose. ■ Easy operation It supports intuitive touchscreen operation. The software design, focused on usability, allows anyone to easily perform application settings, device settings, and sample measurements. *For more details, please download the PDF or contact us.

The "Lyovapor L-200Pro/L-200" is a freeze dryer suitable for research and development prior to production. The "L-200Pro" is a compact tabletop model for laboratory use, yet it has control functions equivalent to those of large-scale pilot production machines, allowing for efficient and smooth preliminary testing. Additionally, the shelves where samples are placed are equipped with built-in heaters, which independently supply thermal energy lost from the samples during sublimation at each shelf level, achieving accurate control with good reproducibility and fast drying processes. 【Features】 ■ Ideal for process control and development of freeze drying ■ Intuitive and easy operation ■ Adjustable angle ■ Supports Japanese language display ■ Freely customizable according to usage purposes *For more details, please refer to the PDF materials or feel free to contact us.

The "Lyovapor L-300Pro/L-300" is a freeze dryer with unlimited processing capacity. The "L-300" has no restrictions on the "amount" that can be continuously operated, and it regularly removes ice from two cooling condensers without interrupting the freeze-drying process in a vacuum state. Additionally, the adhered ice is alternately removed at regular intervals, keeping the cooling surfaces exposed without being covered by thick ice, which consistently maintains high cooling capacity and significantly contributes to speeding up the freeze-drying process. 【Features】 ■ No upper limit on trap capacity ■ Intuitive and easy operation ■ Adjustable angle ■ Japanese language support ■ Freely customizable according to usage purposes *For more details, please refer to the PDF document or feel free to contact us.

The "FlashPure Series" is a cartridge column for flash purification that meets various needs with a rich lineup. We offer a wide range from low-cost types to high-end types focused on separation capability, with various sizes, stationary phases, particle sizes, and packing material types available. ★ A campaign is currently underway until March 2024! Be sure to take advantage of this opportunity♪ 【Campaign Target Products (Excerpt)】 ■ High-performance flash cartridges ▶ FlashPure EcoFlex Silica 12g x 18 pieces ▶ FlashPure EcoFlex Silica 25g x 12 pieces ■ Economical flash cartridges ▶ Flash Pure Select Silica 12g x 18 pieces ▶ Flash Pure Select Silica 25g x 12 pieces

The B-585 is a compact drying device designed with a space-saving design that pursues diverse possibilities in the lab. It is suitable for drying very small to small samples and quickly transitioning to reproducible analysis. With optional units, it can perform drying, distillation, sublimation, and freeze-drying all in one device. 【Features】 - Compact space-saving design - Capable of drying, distillation, sublimation, and freeze-drying in one unit - Transparent structure allows for visual confirmation of samples - Fast heating rate - Three-step program settings based on temperature and time (control of the vacuum pump's power On/Off is also possible) *For more details, please refer to the PDF document or feel free to contact us.

The V-600 is a robust and chemically resistant three-stage PTFE diaphragm vacuum pump that operates very quietly despite its large displacement. It has a displacement of 3.1 m³/h and a vacuum level of 1.5 mbar. With a high degree of flexibility, it can be easily connected to BUCHI laboratory rotary evaporators or industrial evaporators, making it suitable as a vacuum source. 【Features】 ■ Window for confirming contamination ■ Washable pump ■ Quiet operation at 40 dB ■ Easy maintenance (cleaning and diaphragm replacement) ■ Speed control operation via interface I-300/I-300Pro (speed control is also possible with vacuum controllers V-850/V-855) ■ Improved resistance in acidic environments compared to the V-710 *For more details, please refer to the PDF document or feel free to contact us.

This document is a technical material regarding spray drying of advanced materials. Various advanced materials, including ceramics, are used in electronics, medical, aerospace, automotive, and other fields. It introduces how spray dryers are used in the research and development of advanced materials, as well as their importance. [Contents (excerpt)] ■ Groups within a wide range of advanced materials ■ Manufacturing process of ceramics ■ Importance of spray drying method in the production of advanced materials ■ Production of advanced materials using spray drying method ■ Research using BUCHI mini spray dryer *For more details, please refer to the PDF document or feel free to contact us.

ProxiMate is a near-infrared analyzer that allows for the analysis of components in samples in their original state using near-infrared light, in just 15 seconds. Its intuitive operation screen and robust, compact design make it suitable for use in manufacturing environments. Additionally, it offers a wide range of application packages for the analysis of components in food and feed, enabling increased production efficiency and faster quality control. 【Advantages of Implementation】 ■ Measurement possible with glass or plastic petri dishes ■ Color information can be obtained simultaneously ■ Equipped with AutoCal, an automatic calibration curve creation function ■ Compact and does not require a specific installation location ■ Hygienic, high safety, and user-friendly design compliant with EHEDG standards *For more details, please refer to the PDF materials or feel free to contact us.

Easy operation! Does your sample contain compounds without UV absorption? Equipped with both a UV detector and ELSD, it performs fractionation by triggering both simultaneously. Additionally, it can handle higher flow rates and pressures than conventional models (up to 30 MPa). From crude purification to full-scale high-pressure fractionation, purification can be performed with easy operation. 【Features】 ■ SLIM & SAFETY ■ Ensures safety with a closed fraction collection section ■ Built-in UV detector and ELSD ■ Capable of handling high flow rates and pressures ■ Purification can be performed with easy operation *For more details, please refer to the PDF materials or feel free to contact us.

Related Device: Fractionation Chromatography System Pure C-815 Cholesterol and its esters, which are components of biological membranes, are utilized as industrial raw materials in cosmetics, pharmaceuticals, and liquid crystals. When performing gradient fractionation purification for compounds that are difficult to detect with UV detectors, methods are selected using low wavelength UV detection such as 210 nm or ELSD (Evaporative Light Scattering Detector). ELSD is a fractionation purification method that overcomes the disadvantages of UV-triggered fractionation due to the absence of baseline drift and T0 peaks. By adopting ELSD & UV double triggering, it enables complementary fractionation purification using both ELSD and UV. 【Issues with Low Wavelength UV Triggered Fractionation】 ■ The baseline drifts due to the solvent's own absorption used in the mobile phase, making it difficult to detect sample peaks. ■ Baseline rises consistently during gradient steps, leading to the baseline being recognized as a peak, which significantly increases purification time and fraction volume. *For more details, please refer to the PDF document or feel free to contact us.

Related Products: Fractionation Chromatography System Pure C-815 To achieve high-purity precision purification of mid-sized compounds such as peptides, reverse phase LC is commonly applied, and simple rough purification after synthesis or extraction is generally performed using methods like SPE (solid-phase extraction). In rough purification using SPE, adjusting the pH of the solvent allows for easy separation of anions, cations, and non-ions, but separating components of the same ionic type is challenging. Rough purification by flash chromatography enables selective and rapid separation and purification of target compounds through optimization of mobile phase and gradient conditions. 【Mechanism of Rough Purification by SPE】 ■ Easy separation of anions, cations, and non-ions ■ Difficult separation of components of the same ionic type (anions, cations, non-ions) *For more details, please refer to the PDF document or feel free to contact us.

This poster introduces tips on how to shorten the working time involved in "freeze-drying" while ensuring it is done "reliably." It includes topics such as "the freeze-drying process," "effective process control," "requirements for vacuum pumps," and "detection of the end point of drying." We encourage you to take a look. 【Contents (partial)】 ■ Shortening experimental work time through optimization of process parameters ■ Effective process control ■ Cooling condenser ■ Requirements for vacuum pumps ■ Correlation between temperature and vapor pressure of ice *For more details, please refer to the PDF document or feel free to contact us.

The "Rotavapor R-180" is a rotary evaporator equipped with robust performance, an intuitive design, and essential safety features. Designed with durability in mind, it meets the reliable IP42 standard for protection against water droplets. The electric lift allows for smooth and precise height adjustments, automatically raising the flask during power outages to protect the samples. 【Features】 ■ Organizes the workspace for safer operation with a cable holder and tube holder ■ Compact, cordless design of the heating bath ■ Electric lift that automatically raises the flask during power outages ■ Intuitive user interface for efficiently conducting the distillation process ■ Multifunctional combination clip that easily attaches the rotating flask with a snap-lock mechanism ■ Space-saving design (option to mount the vacuum interface I-180 on top) *For more details, please refer to the related links or feel free to contact us.

The "Pure C-900" is an entry-level preparative chromatography model suitable for first-time flash chromatography. The connected devices are automatically recognized due to its modular design, allowing for flexible combinations of peripheral equipment based on application and budget. The time required for preparative purification is about 1/5 that of using an open column, saving both effort and time. Would you like to significantly improve the efficiency of your preparative purification? 【Features】 ■ Easy connection ■ Convenient pre-packed cartridges ■ Reduces consumption and exposure to organic solvents ■ Increased speed and reproducibility with pump-driven liquid delivery and two-solvent gradient elution ■ Powerful pump with a maximum flow rate of 300 mL/min and pressure resistance of 50 bar (5 MPa) ■ UV (254, 275, 325, 365 nm fixed four wavelengths) trigger detects peak elution and automatically collects fractions *For more details, please download the PDF or feel free to contact us.

The S-300 is a professional-grade tabletop spray dryer for laboratories that excels in reproducibility of processing and sample protection, enabling safe and efficient spray drying. It has undergone a full model change for the first time in about 20 years since our conventional model, the B-290. New features such as automatic operation mode and data storage functions have been added to improve work efficiency and enhance management. Customization of functions is also possible, including an auto mode that automates routine tasks and high-temperature support up to 250°C. 【Features】 ■ Options available to automate routine tasks from heating to operation and completion ■ Management of gas spray and pump speed based on actual measurements to improve processing reproducibility ■ Remote control accessible via mobile devices or PCs ■ Complete compatibility with our conventional models ■ Safe handling of organic solvents possible in conjunction with the inert loop S-395 *Product catalogs and technical materials related to spray drying are currently available. You can view them from the "PDF download" section.

The PTFE diaphragm vacuum pump 'V-300', which excels in chemical resistance, is characterized by its very quiet operation and economical performance. With a displacement of 1.8m³/h and a vacuum level of 5mbar, this product is ideal for combination with rotary evaporators. It allows for centralized control of vacuum levels. 【Features】 ■ Speed Control - Quiet operation - Precise pressure control possible ■ Use of High-Quality Materials - High chemical resistance ■ Expandability - Easy connection to the Rotavapor R-300 system ■ Visual Confirmation of Membrane - Allows for visual inspection of any mixed solvents or contaminants ■ Secondary Condenser - Prevents the release of solvents into the atmosphere For more details, please refer to the catalog or feel free to contact us.

The "Rotavapor R-300" is a rotary evaporator equipped with the latest features such as a "Foam Detection and Anti-Bumping Function" that detects foaming and automatically releases the vacuum to eliminate bubbles, and "Remote Monitoring" that allows the display of running parameters on mobile devices. In addition to improved distillation speed due to high-performance baths and pumps, it allows for easy operation with quick start by simply setting the bath temperature. 【Introducing Amazing Features】 ■ Foam Detection and Anti-Bumping Function ■ Remote Monitoring ■ Automatic Distillation ■ Speed Distillation ■ Centralized Control Interface

We would like to introduce our "Melting Point Measurement Device M-560/M-565 Special Campaign 2023." For customers who want to capture melting videos and melting curves on a PC, we have prepared Set C, which includes the "Melting Point Measurement Device M-565," "Sample Loader," and "Melting Point Monitor Software" at a special price, along with other sets that can be chosen based on specific needs. Campaign Period: From August 2023 to the end of December 2023 【Target Products (Excerpt)】 <Set C / For customers who want to capture melting videos and melting curves on a PC> ■ Contents - Melting Point Measurement Device M-565 - Sample Loader - Melting Point Monitor Software ■ Regular Price: ¥2,517,000 → Campaign Price: ¥1,680,000 (Tax included: ¥1,848,000) *For more details, please refer to the PDF document or feel free to contact us.

The "Rotavapor R-80" is an energy-efficient rotary evaporator among its peers. It is an affordable, environmentally friendly solution that efficiently utilizes lab space while meeting our high-quality standards. 【Features】 ■ Fastest rotation speed in Büchi's history ■ Gentle vacuum control reduces the risk of bumping ■ User-friendly interface ■ Easy-to-maintain, cable-free water bath ■ Sophisticated design of oil-free vacuum pump *For product details, please refer to the PDF document or feel free to contact us.

The "Lyovapor L-250/L-250Pro" is a freeze dryer equipped with a cooling condenser that reaches -85°C. It is suitable for samples that may contain residual organic solvents such as acetonitrile, and is also ideal for samples that are easy to melt. Additionally, it uses a non-fluorinated device that has a low environmental impact. 【Features】 ■ Maximum dehumidification capacity: 5kg ■ Compatible with samples that may contain residual organic solvents ■ Uses environmentally friendly non-fluorinated substances ■ Graphical display of the drying process ■ Detection of drying endpoint for flask samples ■ Remote control and monitoring *For more details, please refer to the PDF document or feel free to contact us.

◆◇◆ Lineup ◆◇◆ ◆M-560 Basic type model for visual measurement - A model dedicated to visual measurement of melting and boiling points, an attractive priced melting point measurement device - Suitable for laboratories that require only visual measurement and have a relatively small number of sample specimens - Equipped with a bright and large magnifying lens - Visual measurement of melting and boiling points - Frequency display for boiling point measurement - Temperature calibration SOP function included (calibration with 4 types of reference materials) - Fast heating and cooling rates - Wide temperature range from room temperature to 400°C - Simultaneous measurement of 3 samples possible - Supports IQ/OQ/validation/tracability (optional) - Complies with the Japanese Pharmacopoeia General Rule 13, and adheres to pharmacopoeias such as EP (European Pharmacopoeia) and USP (United States Pharmacopeia)

The Pure series is a space-saving, smartly designed preparative chromatography system. Some models are equipped with an ELSD that does not miss peaks even with samples that have no UV absorption. Standard features include mobile phase residual, waste liquid, and solvent leak sensors. *Excluding C-805. The operation is simple, allowing for separation condition settings, control, and monitoring on a single screen. Parameters can be changed even during preparative purification. 【Features】 ■ Space-saving design ■ By using a solvent container stand, the mobile phase can be positioned at the top of the device ■ High safety ■ The fraction collector's door and ventilation system prevent exposure to solvent vapors ■ Simple operability *For more details, please download the PDF or feel free to contact us.