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  4. Application Note: High Reliability and High Precision Injection of Supercritical Carbon Dioxide Using a Coriolis Flow Controller
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  • Dec 19, 2025
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Dec 19, 2025

Application Note: High Reliability and High Precision Injection of Supercritical Carbon Dioxide Using a Coriolis Flow Controller

ITWジャパン ITWジャパン
Hot Melt Extrusion (HME) is a method that uses heat and pressure to melt polymers and extrude them into molds in a continuous process. HME is widely applied in the plastics industry and has recently been used in pharmaceutical formulations and drug delivery systems. The HME process is used to mix active pharmaceutical ingredients (APIs) with polymers and other excipients at high temperatures and pressures. The extruded material can be cut or crushed into micro-pellets for filling into capsules or compressing into tablets. Highlights: Measurement and control of mass flow rate of supercritical CO2 Achieving accurate flow rates even at low temperatures (below -30°C) Process Solution: Due to the high reliability of Brooks Instrument's Quantim Coriolis mass flow measurement and control for fluids, systems using this mass flow can measure and control the mass flow rate of the liquid CO2 being injected, rather than the pump's operating speed. In the HME process, when CO2 is maintained above its critical temperature and critical pressure, it enters a supercritical state.
Flow scheme
Flow scheme
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Highly Reliable and Accurate Supercritical Carbon Dioxide Injection Using a Coriolis Flow Controller
Hot melt extrusion (HME) is a method that uses heat and pressure to melt polymers and extrude them into molds in a continuous process. HME is widely applied in the plastics industry and has recently been used in pharmaceutical formulations and drug delivery systems. The HME process is used to mix active pharmaceutical ingredients (APIs) with polymers and other excipients at high temperatures and pressures.

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quantim-qmc-analog-hart-rs485-compression-front-538x538.png

Coriolis mass flow controller/meter "QuantimQMC"

The new 3rd generation Quantim QMC Coriolis flow meter is suitable for applications involving the measurement and control of small flow rates of gases and liquids.

The Quantim® QMC Coriolis mass flow controller and meter provide extremely accurate, stable, and reproducible measurement and control for very low flow rates of gases and liquids. This third-generation new Quantim QMC Coriolis mass flow controller and meter contribute to shortening the scale-up period from lab to pilot plant to production by enhancing process quality, production yield, and throughput. The new Quantim QMC Coriolis mass flow series is compatible in terms of mounting dimensions and functionality with the old models of Quantim from Brooks Instrument. 【Features】 ■ True mass flow measurement ■ Accurate density measurement ■ Additional I/O options: 0-10 Vdc, 0-20 mA, RS485 S-Protocol ■ A wide range of seal materials, certificates, and certification options ■ Easily accessible service port *For more details, please refer to the related link page or feel free to contact us.

  • Flow Meter
  • Flow Control

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Enhancement of drug delivery systems through high-precision measurement and control of supercritical CO2 using a Coriolis mass flow meter.

Enhancement of drug delivery systems through high-precision measurement and control of supercritical CO2 using a Coriolis mass flow meter.

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Comprehensive Catalog Product Guide 'flow-pressure-vapor-guide'

Comprehensive Catalog Product Guide 'flow-pressure-vapor-guide'

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【Metal Crack Repair】We repair cracks in metal products without applying heat.

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The "Mechanical Stitch Method" by Nichinichisui Road Machinery Co., Ltd. is a new technique that allows for the repair of metal cracks without the application of heat. By using special bolts and reinforcement plates, cracks are physically removed, and repairs are made without causing any thermal impact to the base material. Repairs can be carried out in environments where open flames cannot be used. Since no heat is applied, the disassembly of equipment is minimized. ◎ For more details, please contact us. ◎ If a detailed technical explanation is needed, please contact us.

Mar 20, 2026

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Aluminum casting repair: Metal crack repair without applying heat.

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The "Mechanical Stitching Method" by Nichinichisui Road Machinery Co., Ltd. is a new technique that allows for the repair of metal cracks without the application of heat. By using special bolts and reinforcement plates, cracks are physically removed, and repairs are made without causing any thermal impact on the base material. Repairs can be carried out in environments where open flames cannot be used. Since no heat is applied, the disassembly of equipment is minimized. ◎ For more details, please contact us. ◎ If a detailed technical explanation is needed, please contact us.

Mar 20, 2026

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AAEON ArrowLake equipped industrial COM module Type 6 standard

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Features: ● Equipped with Intel Core Ultra 7 255H/7 155H/5 225H/5 125H ● LPDDR5x 16GB/32GB/64GB onboard ● M.2 NVMe 256GB onboard ● USB 2.0 x 8, USB 3.2 (10Gbps) x 4 ● PCIe Gen 4 [x8] x 1, PCIe Gen 3 [x1] x 4, PCIe Gen 3 [x4] x 1 (2 lanes co-lay with SATA; BOM option) ● 2.5GbE x 2 ● COM-HPC Mini standard, size 95mm x 70mm ● Optional items ECB-980A: Development carrier board HPC-ARHm-FAN01: CPU fan HPC-ARHm-HSP01: Heat spreader (Note: heat dissipation is required in the enclosure)

Mar 19, 2026

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AAEON ArrowLake-equipped industrial COM module COM-HPC R1.2 Mini standard

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Features: ● Equipped with Jetson AGX Orin 32GB/64GB ● Gigabit LAN ×1, 10Gigabit LAN ×1 ● USB 3.2 Gen 2 (Type-A) ×4 ● DB-9 connector ×1 (for DIO 8 channels) ● DB-9 connector ×2 (supports RS-232/422/485: Rx/Tx/RTS/CTS) ● Jetpack 6.0.0 pre-installed

Mar 19, 2026

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AAEON Amston Lake equipped industrial COM module NANOCOM-ASL Type 10 standard

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Features: ● Equipped with Intel Atom x7835RE/x7433RE ● LPDDR5x 8GB/16GB onboard ● eMMC 32GB/64GB onboard ● LVDS x 1, DDI x 1 ● USB 2.0 x 8, USB 3.2 Gen 2 x 2 ● PCIe x1 x 4 ● COMe Type 10 standard, 84mm x 55mm size ● Operating temperature -40 to 85℃ ● Optional items ECB-920A-0001: Development carrier board NANOCOM-ADN-FAN01: CPU fan NANOCOM-ADN-HSP01: Heat spreader (※ Heat dissipation is required in the enclosure)

Mar 19, 2026

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