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Fully synthetic (Chemically Defined) medium for the production of exosomes from human mesenchymal stem cells (MSCs)!

MSH-EV medium is a fully synthetic medium for the production of exosomes from human mesenchymal stem cells (MSCs). It has minimal contamination with microparticles, making exosome purification easier. It can support both expansion culture and exosome production in the same medium.

• Human cells

This is a serum-free medium that does not contain components derived from other species (xeno-free) and shows superior proliferation compared to 20% FBS supplemented αMEM medium.

This is a serum-free medium that does not contain components derived from non-human animal sources (xeno-free) (it does not contain bovine fetal serum (FBS) or human platelet lysate). The protein components consist solely of recombinant proteins expressed in microorganisms and human serum-derived albumin (pharmaceutical grade).

• Culture medium

Directly usable for mycoplasma detection tests based on each protocol!

Features of our Mycoplasma Detection Test Liquid Medium - Composition based on biological product standards - Demonstrates growth capability that meets the performance testing criteria of the Japanese Pharmacopoeia and biological product standards - Ready-to-use liquid medium that can be directly used for Mycoplasma detection tests based on various official standards - Usable for one year when stored at -20°C or below - Manufactured domestically

• Other cell research

Obtained a materials eligibility confirmation letter for regenerative medicine products from PMDA!

This product shows a higher proliferation support capability than the basic medium when supplemented with "UltraGRO" (AventaCell BioMedical product) and MSF-Supplement A.

• Culture medium

We can provide samples of human mesenchymal stem cell culture media (low serum, serum-free), exosome production media, etc.!

Shimadzu Diagnostics offers unique media developed in-house. Samples are available for all, so please feel free to contact us.

• Culture medium

Our culture medium products have obtained the Material Qualification Certificate for Regenerative Medicine Products!

The human mesenchymal stem cell proliferation medium MSF-BM and the serum-free culture medium DCO-K for immune cell therapy research have obtained the "Confirmation of Material Suitability for Regenerative Medicine Products" from the PMDA (Pharmaceuticals and Medical Devices Agency). Both media have been confirmed to comply with the standards for biological raw materials, allowing them to be used safely as raw materials for regenerative medicine products. For inquiries regarding the confirmation of material suitability for regenerative medicine products (PMDA): https://www.pmda.go.jp/review-services/f2f-pre/consultations/0035.html They are listed in the "List of Products that Have Obtained Confirmation" on the FIRM (Regenerative Medicine Innovation Forum) website. https://firm.or.jp/standard/support-s/1732/

• Culture medium

It is possible to achieve high sensitivity and rapid detection of viruses as described in the law concerning the assurance of safety in regenerative medicine and other related fields!

The gene detection kit VirFinder for virus denial testing can detect eight types of viruses listed in the law concerning the assurance of safety in regenerative medicine and other fields.

• Other Culture

Available as an alternative method to culture methods and DNA staining methods in mycoplasma detection tests!

"Myco Finder" is a solid-phase kit that simplifies the complex procedures of mycoplasma detection tests and allows for rapid testing. Since the reagents are solid-phased on the test strip, they only need to be dissolved during testing, which reduces the risk of contamination. Furthermore, with the adoption of high-speed amplification enzymes, the detection time is shorter than before, taking less than one hour from the start of amplification, allowing for results to be determined within a day. 【Features】 ■ No reagent preparation required ■ Detection time is within one hour from the start of amplification ■ High sensitivity ■ Can be stored in a cool place (2–8°C) *For more details, please refer to the catalog or feel free to contact us.

• Other purification and extraction

We will support you with all our strength! Please let us know your concerns regarding cell culture!

We would like to introduce our "Contract Manufacturing Service for Cell Culture Media." Manufacturing is possible in facilities where airborne particles and microorganisms are controlled. The raw materials used comply with biological origin material standards. Operations are managed based on the ISO 9001 quality management system. 【Features】 ■ Capable of producing both powdered and liquid media ■ Thorough manufacturing and quality control ■ We also offer analytical services as an option to provide suitable media - Simultaneous analysis of 95 components contained in the media - Effective when you want to know important indicators for managing cell culture processes and components that provide hints for media improvement *For more details, please refer to the PDF document or feel free to contact us.

• Culture medium

Important indicators for cell culture process management and tips for medium improvement! Simultaneous analysis of 95 components contained in the medium.

The "Cell Culture Medium Analysis Service" conducts component analysis using LCMS to examine changes in medium components before and after culture, as well as metabolites secreted by cells. This service is effective when you want to know about the components, providing data to achieve a suitable medium for the cells you use. We provide medium samples, so please feel free to contact us. 【Features】 ■ Simultaneous analysis of 95 components contained in the medium ■ Important indicators for managing cell culture processes and hints for medium improvement ■ Provision of medium samples ■ Custom manufacturing based on analysis results - GMP grade and research grade options available *For more details, please refer to the PDF materials or feel free to contact us.

• Culture medium

● The production time for casting prototypes can be shortened! Since model making is not required, the production time for prototypes, which previously took about a month, can be significantly reduced. ● Model costs can be reduced! By directly creating sand molds from 3D data, there is no need for model production costs. If changes to the model are necessary, they can be addressed by modifying the 3D data. ● Similar products with different shapes and dimensions can be prototyped simultaneously! Different products, such as similar shapes or variations in dimensions, can be created in a single molding process. This allows for the verification of multiple types in a short period.

The "Mechanical Stitching Method" by Nichinichisui Road Machinery Co., Ltd. is a new technique that allows for the repair of metal cracks without the application of heat. By using special bolts and reinforcement plates, cracks are physically removed, and repairs are made without affecting the base material with heat. Repairs can be carried out in environments where open flames cannot be used. Since no heat is applied, the disassembly of equipment is minimized. ◎ For more details, please contact us. ◎ If a detailed technical explanation is needed, please contact us.

Dear Sir/Madam, I would like to express my congratulations on the continued prosperity of your company. Thank you very much for your exceptional support. We would like to inform you that our company will be closed for winter holidays during the following period. We apologize for any inconvenience this may cause and kindly ask for your understanding. 1. Winter Holiday Period From Thursday, December 28, 2023, to Thursday, January 4, 2024. 2. Business Operations After the Winter Holiday Period We will resume normal operations from Friday, January 5, 2024.

● This is a leak testing device for small electronic components that does not use fluorinated inert liquids (PFAS-free). ● There is no longer a need for unstable visual confirmation through liquid immersion testing. It adopts a quantitative testing method that allows for stable pressure leak testing. ● It is a tabletop leak testing device specifically for gross leaks, with accuracy equal to or greater than that of liquid immersion testing. ● The detectable range is approximately 1×10⁻² Pa·m³/s to 1×10⁻⁶ Pa·m³/s (varies depending on the target product). ● It is suitable for sealed structures ranging from a few millimeters to a maximum of 80 × 70 mm. Please feel free to contact us for more information!

● The production time for casting prototypes can be shortened! Since model production is not required, the time needed to create prototypes, which previously took about a month, can be significantly reduced. ● Model costs can be reduced! By directly producing sand molds from 3D data, there is no need for model production costs. If changes to the model are necessary, they can be addressed by modifying the 3D data. ● Similar products with different shapes and dimensions can be prototyped simultaneously! With one molding process, different products with similar shapes or varying dimensions can be molded at the same time. This allows for the verification of multiple types in a short period.