<Maurice Data> Overcoming challenges in the analysis of large biomolecules at Maurice - Rapid analysis of IgM proteins using Turbo CE-SDS cartridges -

The immunoglobulin M (IgM) molecule has a pentameric or hexameric structure that provides particularly high binding strength, allowing it to bind to antigens present at low concentrations, which has led to active research into its therapeutic potential.
Currently, there are over 100 IgM-based therapeutics undergoing clinical trials for the treatment of various diseases. Examples include Imvotamab (non-Hodgkin lymphoma), IgM-8444 (colorectal cancer), and IgM-7354 (solid tumors).
The large size of the IgM molecule (approximately 950 kDa) can pose challenges in characterization.
We introduce an analysis method for IgM proteins using capillary electrophoresis sodium dodecyl sulfate (CE-SDS) with Turbo CE-SDS cartridges on the Maurice platform.
Both CE-SDS and imaging capillary isoelectric focusing (icIEF) methods can be performed on a single Maurice system for the characterization of a wide range of proteins, including mAbs, fusion proteins, and ADCs, significantly saving effort, resources, and time.

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