[Exhibition Information] 25th International Heart Research Conference World Congress

A patch clamp system that incorporates a patch clamp amplifier, achieving miniaturization and reduction of installation costs, allowing for easy data acquisition and verification.

This is a world-class patch clamp system capable of performing gigaseal recordings, optimal for safety testing/toxicity testing/pharmacological testing/screening of compounds at the cellular level in the functional structural analysis of ion channels, research on related diseases, and drug development processes. ■ No experience with manual patch clamping or difficult operations required ■ No need for microscope/vibration isolation table/manipulator/Faraday cage/puller ■ 20 to 50 data points per day ■ Automation from gigaseal formation to whole cell formation ■ Compatible with voltage-dependent and ligand-dependent channels through pipetting ■ Measurement of action potentials using current clamp is also possible ■ Supports a wide range of applications, enabling rapid assay system development ■ Reduces compound adsorption with borosilicate glass chips

• Other physicochemical equipment
• Analytical Equipment
• Patch clamp system

A world-class patch clamp system that is easy to operate for anyone, allowing for simple data acquisition and verification.

This is a patch clamp system of the world's smallest class that can perform gigaseal recordings, optimal for safety testing/toxicity testing/pharmacological testing/screening of compounds at the cellular level in the functional structural analysis of ion channels, research on related diseases, and drug development processes. 【Features】 ■ No need for manual patch clamp experience or difficult operations ■ No need for microscope, vibration table, manipulator, Faraday cage, or puller ■ 20 to 50 data points per day ■ Automation from gigaseal formation to whole cell formation ■ Compatible with voltage-dependent, ligand-dependent, and temperature-dependent channels ■ Options available for research on channel rhodopsins and mechanosensitive channels using light stimulation ■ Measurement of action potentials using current clamp is also possible ■ Supports a wide range of applications and enables rapid assay system development ■ Reduces compound adsorption with borosilicate glass chips ■ Optional temperature control (10 to 50°C), capable of extracellular/intracellular perfusion ■ Can be integrated with amplifiers such as HEKA and Axon *For details, please refer to the catalog available for download in PDF.

• Other physicochemical equipment
• Analytical Equipment
• Patch clamp system

Nanion Technologies realizes the automation of electrophysiology experiments and supports a wide range of membrane protein-related research.

**Catalog Products** ■ Auto Patch Clamp System Ideal for evaluating the effects of compounds on ion channels and for functional and structural analysis of ion channels. From a compact system that allows you to check data immediately at hand to high-throughput systems for compound screening in pharmaceutical research and development. ■ Artificial Lipid Bilayer Experimental Device For functional and structural evaluation of target membrane proteins reconstituted into artificial lipid bilayers, as well as for evaluating drug actions. ■ Liposome Preparation Device Quickly and easily automates the preparation of liposomes without hassle. ■ Transporter Activity Measurement Device Enables label-free and real-time direct measurement of transporter currents without using fluorescent probes or radiolabeled ligands. ■ iPS-Derived Cardiomyocyte Measurement System For assessing cardiotoxicity, contractility, and drug screening using iPS-derived cardiomyocytes. ■ Cell Monitoring Device Allows for label-free and real-time high-throughput measurement of cell kinetics (up to 6 x 96-well plates).

• Analytical Equipment
• Patch clamp system
• Other Analysis

We would like to extend our heartfelt congratulations on the continued prosperity of your esteemed company. Our company will be exhibiting at the following trade show, where we will introduce a number of products, including our new product, the Pillow Packaging Full Air Tightness Inspection Machine MSQ-2003. We sincerely apologize for the inconvenience during your busy schedule, but we would like to invite you to visit us at this opportunity. 【 Exhibition Name 】 JAPAN PACK 2025 Japan Packaging Industry Exhibition https://www.japanpack.jp/ 【 Dates 】 October 7 (Tuesday) to October 10 (Friday), 2025 *4 days 10:00 AM to 5:00 PM 【 Venue / Booth Number 】 Tokyo Big Sight / East Hall 8, Booth 8-505

8-15 OCTOBER ２０２５　 Exhibit at K2025 -World`s No.1 Trade Fair for Plastics & Rubber

【Key Points of This Seminar】 - What is "push-type"? The true nature of common waste in the workplace - Basic principles of pull production and steps for on-site implementation - The concept of "downstream pull" to reduce work-in-progress and inventory - Case studies of companies that have made improvements - Specific methods for establishing a small start 【Target Audience: Improvement leaders and management】 - Those who feel there is too much "overproduction," "bottlenecks," and "wasteful movements" in the workplace - Those struggling with the gap between production planning and actual work - Those looking for ways to sustain improvement activities - Those who want to know practical methods for implementing TPS (Toyota Production System) ~ Visualizing waste to achieve "just enough, when needed" ~ "Is your workplace being 'pushed'?" In the workplace, issues such as "produced but not used" and "work-in-progress overflowing and halting flow" are common. Many of these problems may stem from push-type production, where items are made "just in case" rather than "because they are needed." A chain moves easily when "pulled," but what happens when it is "pushed"? ── This is precisely the difference between push and pull. We will teach you the system of production that "does not overproduce and does not stagnate" based on the concept of "pull production."

**Seminar Points** Improvement means changing standards for the better. There can be no improvement where there are no standards. If there are no standards, start by creating them. Standards are "rules." What to decide are "procedures," "methods," and "timing." This seminar is focused on determining "procedures" and creating "work instruction documents." **"Without standards, there is no improvement" — Learning from Toyota's teachings on documentation in the workplace** The source of Toyota's strength lies in the concepts of "improvement" and "standardization." At the core of this is a culture of making insights and skills visible in the workplace and documenting them. In other words, it is a system of knowledge transfer through documentation. Relying on the experience and intuition of veterans can be a strength in the workplace, but it also carries the risk that quality may change when people change. By ensuring that everyone performs tasks in the same way, we can achieve the same quality products (good products) in the same amount of time. First and foremost, the development of "work instruction documents" is essential. When presenting work instruction documents in video format, it is also a prerequisite that this "foundational document" is well established. *For more details, please download the PDF or contact us.*

Kobayashi Co., Ltd. will be exhibiting at the 5th Sustainable Materials Exhibition (SUSMA) held at Makuhari Messe. This exhibition is a specialized event focused on sustainable materials (environmentally friendly materials) and their manufacturing and recycling technologies. Technicians, product planners, and management from various industrial sectors such as electronics, automotive, batteries, and construction materials, as well as manufacturers of food, beverages, daily necessities, and miscellaneous goods will be attending. We sincerely look forward to your visit.