How can we streamline the creation of separation methods for active pharmaceutical ingredients and nitrosamines? Nitrosamine Analysis Workshop [Tokyo, Osaka]

The self-inspection period will soon end. Are you ready for the upcoming operations?

The self-inspection regarding the contamination of nitrosamines in pharmaceuticals, notified by the Ministry of Health, Labour and Welfare in October 2021, has a deadline of August 1, 2025. By the deadline, it is necessary to measure the amount of nitrosamines contained in items at risk of contamination, and if the levels exceed the limit, risk reduction measures such as setting standard values must be taken. When setting standard values for nitrosamines, it is essential to use systems and analytical conditions that enable high-sensitivity analysis, and we also want the systems to have the robustness to withstand daily analysis. Waters supports high-sensitivity and robust analysis of nitrosamines with total solutions including high-sensitivity and robust mass spectrometers, LC systems and columns that achieve high separation, and informatics, as a specialized manufacturer of LC and mass spectrometry. By clicking [Submit], you are deemed to have agreed that Waters will use and process the information provided on this site in accordance with Waters' Terms of Use and Privacy Notice. Terms of Use and Privacy Notice www.waters.com/legalandprivacy

• Liquid Chromatograph
• Mass Spectrometer
• High Performance Liquid Chromatograph

Are you satisfied with just high sensitivity? - Ultra-high sensitivity LC-MS/MS that maintains stable operation for a long time and is easy to maintain.

Many people are struggling with systems that are prone to contamination and time-consuming maintenance. The Xevo TQ Absolute, known for its resistance to contamination thanks to the "ZSpray Ion Source," along with a new source shield, minimizes contamination of the ion source from sample matrices and salts in the mobile phase. It also allows for the removal of neutral molecules before the mass separation section (StepWave XS), concentrating ions for introduction into the mass separation section. This helps maintain the system in a "good condition" for a longer period, maximizing uptime. As a latest high-sensitivity model, it achieves higher sensitivity and lower quantitation limits. Additionally, it is more compact compared to conventional products, reducing power and gas consumption by about 50%, and also decreasing heat generation by approximately 50%. 【Features】 - Sensitivity to anionic compounds improved by up to 15 times (compared to previous products) - Ensures consistent robustness and reproducibility, maintaining performance and productivity over a longer period - Reduces electricity and gas consumption by about 50% compared to typical high-performance TQ mass spectrometers, with heat generation also reduced by about 50%

• Mass Spectrometer

Reliable characteristic analysis - A mass spectrometer that maximizes information about the analysis species.

By using the Xevo G3 QTof, you can maximize the information about the analysis species from samples, enhancing the reliability of results from detailed characterization to accurate quantification. It simplifies and expands the characterization and evaluation of properties, from unstable low molecular weight compounds to complex biopharmaceuticals. By updating the design of the ion optical system and incorporating core technologies that achieve comprehensive quantification capabilities, consistent robustness and performance have been achieved. 【Features】 - Improved permeability of unstable low molecular compounds maximizes coverage of analysis species - Enhanced quantitativeness and expanded dynamic range within and between spectra enable optimal comprehensive quantification/qualitative analysis for screening and target applications - Improvements in the ion optical system lead to a more reliable and robust system - Achieves high levels of accuracy and reproducibility

• Analytical Equipment and Devices

Solving non-specific sample adsorption! Improved peak shape and sensitivity with new technology, featuring low adsorption and bio-inert LC with excellent reproducibility and durability.

The ACQUITY Premier system incorporates the new MaxPeak High Performance Surfaces (HPS) technology, which effectively reduces sample loss due to nonspecific adsorption caused by interactions with metals, while providing the following benefits: ■ Ideal for the analysis of organic acids, organophosphates, oligonucleotides, peptides, glycoproteins, phospholipids, veterinary drugs, chelating agents, and more. ■ Improved sensitivity and reduced risk of peak omission. ■ Elimination of column and system passivation and conditioning, saving time and costs. ■ Enhanced reproducibility and reliability of results. A variety of low-adsorption columns featuring MaxPeak High Performance Surfaces (HPS) technology are also available. When used in combination with the system, they enable more reliable analyses. *We also offer online briefings and demonstrations, so please feel free to contact us.

• Analytical Equipment and Devices

In the fields of precision machinery and medical devices, precision management at the micron and nano level is essential. A key component in this is the ultra-small diameter pin gauge. In particular, pin gauges made of carbide are excellent in wear resistance and strength, achieving stable measurements. This page explains the applications and benefits of introducing ultra-small diameter pin gauges, so please take a look.

The "Mechanical Stitching Method" by Nichinichisui Road Machinery Co., Ltd. is a new technique that allows for the repair of metal cracks without the application of heat. By using special bolts and reinforcement plates, cracks are physically removed, and repairs are made without causing any thermal impact to the base material. Repairs can be carried out in environments where open flames cannot be used. Since no heat is applied, the disassembly of equipment is minimized. ◎ For more details, please contact us. ◎ If you require a detailed technical explanation, please contact us.

The "Mechanical Stitching Method" by Nichinichisui Road Machinery Co., Ltd. is a new technique that allows for the repair of metal cracks without the application of heat. By using special bolts and reinforcement plates, cracks are physically removed without causing any thermal impact on the base material. Repairs can be made even in environments where open flames cannot be used. Since no heat is applied, the disassembly of equipment is minimized. ◎ For more details, please contact us. ◎ If a detailed technical explanation is needed, please contact us.

Combining LIXIL's aluminum profiles manufactured in Japan with precise parts delivered from the German company Schüco, perfectly matching the color and texture of both—this is a rare craftsmanship where Japan's delicacy resonates with Germany's rationality.

Stamp duty, which can be a significant cost in contract business... By switching to electronic contracts, you can reduce this cost. The PDF files of contracts used in electronic contracts do not fall under taxable documents according to the Stamp Duty Act. Therefore, by switching to electronic contracts, you eliminate the need for physical stamps. ◆ "Electronic Contracts" without worrying about stamp duty When you use electronic contracts, there is no stamp duty. Electronic contracts can prove "authenticity" and "non-repudiation" through electronic signatures with electronic certificates and timestamps from certified service providers. * Electronic signature: Ensures authenticity through email addresses, identification, and certificates of registered matters. * Certified service provider timestamp: Proves that the document "existed" at that time and in that state, indicating that it has "not been altered." ◆ For inquiries about electronic contract services, contact paperlogic! "paperlogic Electronic Contract" is a cloud service specialized in electronic contracts and document management. It can be used not only for managing estimates and invoices but also for electronic contracts using witness-type (equivalent to a seal) and party-type (equivalent to a registered seal). Additionally, we offer consulting plans for DX, so please feel free to contact us.