How can we streamline the creation of separation methods for active pharmaceutical ingredients and nitrosamines? Nitrosamine Analysis Workshop [Tokyo, Osaka]

The self-inspection period will soon end. Are you ready for the upcoming operations?

The self-inspection regarding the contamination of nitrosamines in pharmaceuticals, notified by the Ministry of Health, Labour and Welfare in October 2021, has a deadline of August 1, 2025. By the deadline, it is necessary to measure the amount of nitrosamines contained in items at risk of contamination, and if the levels exceed the limit, risk reduction measures such as setting standard values must be taken. When setting standard values for nitrosamines, it is essential to use systems and analytical conditions that enable high-sensitivity analysis, and we also want the systems to have the robustness to withstand daily analysis. Waters supports high-sensitivity and robust analysis of nitrosamines with total solutions including high-sensitivity and robust mass spectrometers, LC systems and columns that achieve high separation, and informatics, as a specialized manufacturer of LC and mass spectrometry. By clicking [Submit], you are deemed to have agreed that Waters will use and process the information provided on this site in accordance with Waters' Terms of Use and Privacy Notice. Terms of Use and Privacy Notice www.waters.com/legalandprivacy

• Liquid Chromatograph
• Mass Spectrometer
• High Performance Liquid Chromatograph

Are you satisfied with just high sensitivity? - Ultra-high sensitivity LC-MS/MS that maintains stable operation for a long time and is easy to maintain.

Many people are struggling with systems that are prone to contamination and time-consuming maintenance. The Xevo TQ Absolute, known for its resistance to contamination thanks to the "ZSpray Ion Source," along with a new source shield, minimizes contamination of the ion source from sample matrices and salts in the mobile phase. It also allows for the removal of neutral molecules before the mass separation section (StepWave XS), concentrating ions for introduction into the mass separation section. This helps maintain the system in a "good condition" for a longer period, maximizing uptime. As a latest high-sensitivity model, it achieves higher sensitivity and lower quantitation limits. Additionally, it is more compact compared to conventional products, reducing power and gas consumption by about 50%, and also decreasing heat generation by approximately 50%. 【Features】 - Sensitivity to anionic compounds improved by up to 15 times (compared to previous products) - Ensures consistent robustness and reproducibility, maintaining performance and productivity over a longer period - Reduces electricity and gas consumption by about 50% compared to typical high-performance TQ mass spectrometers, with heat generation also reduced by about 50%

• Mass Spectrometer

Reliable characteristic analysis - A mass spectrometer that maximizes information about the analysis species.

By using the Xevo G3 QTof, you can maximize the information about the analysis species from samples, enhancing the reliability of results from detailed characterization to accurate quantification. It simplifies and expands the characterization and evaluation of properties, from unstable low molecular weight compounds to complex biopharmaceuticals. By updating the design of the ion optical system and incorporating core technologies that achieve comprehensive quantification capabilities, consistent robustness and performance have been achieved. 【Features】 - Improved permeability of unstable low molecular compounds maximizes coverage of analysis species - Enhanced quantitativeness and expanded dynamic range within and between spectra enable optimal comprehensive quantification/qualitative analysis for screening and target applications - Improvements in the ion optical system lead to a more reliable and robust system - Achieves high levels of accuracy and reproducibility

• Analytical Equipment and Devices

Solving non-specific sample adsorption! Improved peak shape and sensitivity with new technology, featuring low adsorption and bio-inert LC with excellent reproducibility and durability.

The ACQUITY Premier system incorporates the new MaxPeak High Performance Surfaces (HPS) technology, which effectively reduces sample loss due to nonspecific adsorption caused by interactions with metals, while providing the following benefits: ■ Ideal for the analysis of organic acids, organophosphates, oligonucleotides, peptides, glycoproteins, phospholipids, veterinary drugs, chelating agents, and more. ■ Improved sensitivity and reduced risk of peak omission. ■ Elimination of column and system passivation and conditioning, saving time and costs. ■ Enhanced reproducibility and reliability of results. A variety of low-adsorption columns featuring MaxPeak High Performance Surfaces (HPS) technology are also available. When used in combination with the system, they enable more reliable analyses. *We also offer online briefings and demonstrations, so please feel free to contact us.

• Analytical Equipment and Devices

● The production time for casting prototypes can be shortened! Since model production is not required, the time needed to create prototypes, which previously took about a month, can be significantly reduced. ● Model costs can be reduced! By directly producing sand molds from 3D data, there is no need for model production costs. If changes to the model are necessary, they can be addressed by modifying the 3D data. ● Similar products with different shapes and dimensions can be prototyped simultaneously! With one molding process, different products with similar shapes or varying dimensions can be molded at the same time. This allows for the verification of multiple types in a short period.

The "Mechanical Stitching Method" by Nichinichisui Road Machinery Co., Ltd. is a new technique that allows for the repair of metal cracks without the application of heat. By using special bolts and reinforcement plates, cracks are physically removed, and repairs are made without causing any thermal impact to the base material. Repairs can be carried out in environments where open flames cannot be used. Since no heat is applied, the disassembly of equipment is minimized. ◎ For more details, please contact us. ◎ If you require a detailed technical explanation, please contact us.

A "non-contact switch" that allows you to open and close doors simply by waving your hand, without directly touching the doorknob or switch! By adopting microwave technology, the risk of malfunction due to condensation in environments with temperature differences, such as cold storage warehouses, is significantly reduced. It reduces the risk of virus and bacterial infections in places where hygiene is a concern, such as food factories, hospitals, nursing facilities, and restaurant kitchens. 【Features】 ○ Reduces the risk of virus infection by allowing door operation without contact ○ Waterproof and dustproof (IP55 design), allowing the main unit to be washed with water (note: the wall surface (back side) is not applicable) ○ LED display and response sound allow for easy confirmation of detection status ○ Two pattern settings for one-shot and latch output are possible ○ The thinnest in the industry! Only 22mm thick! ◎ For more details, please download the catalog or contact us.

Japan is among the top 10 countries in the world with frequent earthquakes. The 2020 White Paper on Land, Infrastructure, Transport and Tourism has also reported an increase in the probability of significant earthquakes occurring. For the Nankai Trough earthquake, the probability of an earthquake with a magnitude of 8 to 9 occurring within the next 30 years is estimated to be 70 to 80%. At Hotron, we recommend the introduction of seismic devices for earthquake measures in buildings and equipment. The seismic device 'HK-2' is a product that automatically performs various controls that have been pre-set when it detects strong shaking equivalent to a seismic intensity of 5 lower or higher. For example, it can automatically execute actions such as: "Open automatic doors and gates to secure evacuation routes and access for emergency vehicles" "Transmit signals to the control room and stop facility equipment" "Unlock the keys to locked lockers" "Automatically play voice guidance" ◎ For more details, please download the materials or contact us.

The non-contact beam touch sensor "HA-T401/HA-T520" has a compact detection range, making it an ideal automatic door sensor for installation on automatic doors facing narrow corridors or busy streets. Depending on the application and installation location, you can choose between "non-vision mounting type" and "non-vision built-in type." 【Features】 ● With the beam touch sensor, you can open and close the automatic door simply by bringing your hand close without touching it, ensuring hygiene. ● Depending on the installation environment, such as single sliding or bi-parting doors, the detection range can be set in four ways: left, center, right, with 4 spots and 12 spots settings. ● Two types of activation row settings are available to reduce unnecessary opening and closing of the automatic door due to cross traffic, contributing to energy-saving effects. ● The touch switch and infrared sensor are integrated, allowing for a switch between beam touch and infrared sensor modes with a single model. 【Recommended for such places!】 ☑ Entrances facing busy corridors ☑ Counters or signs near the door ☑ Buildings facing narrow corridors ☑ Buildings that prioritize aesthetics ☑ Hospitals and facilities that consider hygiene ☑ Large facilities with many doors ◎ For more details, please download the materials or contact us.