gPROMS FormulatedProducts 1.4 Release (April 18)

Process model library (reaction, crystallization, wet and dry grinding, spray drying, wet and dry granulation, blending, and tablet compression, etc.)

gPROMS Formulated Products is equipped with a library of process models for operations such as reactions, crystallization, wet and dry milling, spray drying, wet and dry granulation, blending, and tablet compression. In case studies applied to pharmaceutical processes, it enables consistent performance analysis of the entire system from active pharmaceutical ingredient (API) manufacturing through formulation processes to oral absorption risk analysis. ■ Solution crystallization analysis ■ Solid-liquid and solid-gas separation, classification, and granulation process analysis ■ Oral absorption analysis This product was developed with the cooperation of major pharmaceutical companies in Europe and the United States. By using mathematical models of raw materials, unit operations, and product performance, it allows for formulation design aimed at optimizing pharmaceuticals and their manufacturing. It enables faster screening of new formulation candidates against quality attributes, including in vivo performance and manufacturability.

• simulator
• Other analyses
• Analysis Services

Regardless of your license usage, anyone interested in gPROMS, including companies, researchers, and students, is welcome to participate!

At SPSE, we regularly conduct product demonstrations and practical training for our products. The participation fee is free, so please feel free to join us. You will have the opportunity to use the software! ■ Introduction to gPROMS Process Model-based process engineering (batch and continuous processes) Catalyst reactor, adsorption separation, and membrane separation model library ■ Custom Modeling ■ Bioprocess Models ■ gPROMS Formulated Products Crystallization Analysis ■ gPROMS Formulated Products Oral Absorption Analysis *Please note that registration may take some time. We recommend applying early.

• simulator
• Other analyses
• Analysis Services

For increasing production volume, optimizing operations, scale-up design, cost reduction, energy saving, etc.!

<gPROMS FormulatedProducts Crystallization Process Library> It can be used for various considerations and decision-making in production volume enhancement, operational improvement, and process optimization. To build efficient procedures (recipes) in the crystallization process, we will efficiently carry out operations in the following flow and achieve these within a short period (approximately 1 to 2 months). Modeling → Experiment → Model Verification (Parameter Estimation, Validation) → Process Optimization Consideration → Scale-Up Consideration The ability to automatically perform parameter estimation with the tool is a significant factor in reducing the consideration period. Additionally, since it is a kinetic model (expressing mechanisms in mathematical formulas), the number of parameters is kept to a necessary minimum. Furthermore, tools that automatically optimize cooling temperature reduction methods and patterns, the amount and timing of seed crystals, evaporation rates, and heating patterns are powerful, and scale-up may be conducted in conjunction with CFD (Computational Fluid Dynamics) simulations when necessary.

• Contract Analysis

The glass pot lid has a hydrophilic heat-resistant coating, allowing you to check the cooking state without any fogging.

Based on practical experience in support companies and business companies, SBS Marketing Co., Ltd. provides consulting services related to marketing, sales promotion, and customer attraction mainly in the BtoB (business-to-business) sector. On August 7, 2025 (Thursday), they published a page titled "Can You Leave an 'Impact' in Business Meetings and Presentations!? 'Echoic Memory'". 'Echoic Memory' is the temporary storage of auditory information received through the ears. The page explains the mechanisms and examples of its occurrence, the differences from 'Iconic Memory', points to maximize its effectiveness, and advanced utilization techniques. (Page Overview: Excerpts) ■ What is 'Echoic Memory'? ■ The mechanism of 'Echoic Memory' and familiar examples ■ 'Echoic Memory' and 'Iconic Memory' ■ Examples of utilization in business scenes ■ Four points to maximize the effectiveness of 'Echoic Memory' ■ Advanced utilization techniques for 'Echoic Memory' (DL content only) ▼ For more details, please visit this page. https://sbsmarketing.co.jp/blog/echoic-memory-2025-08/

We would like to inform you that our company has recorded a special loss (executive retirement benefits) for the first half of the fiscal year ending December 2025, as detailed below. Furthermore, the payment of executive retirement benefits was approved at the "51st Annual General Meeting of Shareholders" held on March 28, 2025. 1. Recording of Special Loss In recognition of the long-standing contributions of one retiring director, we have recorded a special loss of 14,045 thousand yen as executive retirement benefits. 2. Impact on Performance The impact of this matter on the performance forecast for the fiscal year ending December 2025 is minimal. End.

We will disclose the interim financial results for the fiscal period ending December 2025.

As part of the "Hometown Ibara Future Creation Human Resource Development Project," we welcomed local elementary and middle school students to the special summer program "Ibara Job Exploration Tour 2025," a collaboration between the Ibara City Chamber of Commerce and the Corporate Branding Committee. We conducted a presentation that clearly and enjoyably introduced how our technology supports society, allowing the children to learn about the appeal of manufacturing and the significance of working while interacting with actual devices and products. Through this initiative, we hope to deepen our connection with the community and nurture the curiosity of the children who will carry the future. We sincerely thank everyone who participated, as well as all those involved in planning and organizing the event.