[Sending recorded video] 11/2 [Every Tuesday in Japan] Process Enhancement Series, all 3 sessions - Session 2: High-Throughput Bioreactor Supporting Process Enhancement Efforts

Process enhancement. Modify. Intensify. Amplify.

Process Intensification (PI) is a comprehensive framework aimed at maximizing overall production volume across manufacturing units, manufacturing processes, or biopharmaceutical facilities. Sartorius Stedim offers scalable and versatile modular solutions, including high-throughput process development tools. These can be implemented in current and future manufacturing facilities for a variety of upstream and downstream PI scenarios. - Enables faster drug development - Improves efficiency and productivity in GMP manufacturing - Applicable to various processes regardless of the pharmaceutical ◆ International Webinar [Process Intensification Webinar Series] This webinar series provides a comprehensive guide to maximizing process intensification. It covers upstream and downstream strategies, media management, data analysis, and more. You can watch it here: ⇒ https://bit.ly/3ihwdT1

• Other physicochemical equipment

Industry-standard high-throughput bioreactor system optimized for process characteristic analysis.

The Ambr 250 High Throughput Generation 2 is a multi-parallel bioreactor system that accelerates process development and characterization analysis schedules to achieve cost reduction. Its fully continuous gas supply system realizes similarity with large-scale bioreactors and optimizes the scale-down model. Through the integration of analysis options such as the capacitance-based BioPAT Viamass, it supports extensive feedback control.

• others
• Culture Equipment
• Bioreactor

A fully automated bioreactor system for the development of high-density cell culture processes!

The "Ambr250 Perfusion" is a fully automated multi-parallel bioreactor system that uses single-use culture vessels of 100-250 mL to accelerate the development of scalable perfusion processes. This system allows for the simultaneous execution of up to 24 different perfusion cultures while returning cells to the culture vessel using hollow fibers, which are commonly reported specifications. This system transforms the perfusion processes that could not be achieved with multi-parallel or small-scale setups, reducing experimental costs with small volumes and accelerating the optimization of high-density cell culture processes. 【Features】 ■ Increased productivity / Reduced experimental costs ■ Simultaneous parallel fed-batch and perfusion cultures are also possible ■ Exceptional scalability ■ Sampling and reagent addition are performed by a fully automated liquid handler, reducing daily working hours *For more details, please refer to the PDF document or feel free to contact us.

• Other physicochemical equipment

A fully automated tool for acquiring and fully utilizing Raman spectroscopy data to build a robust cultivation process for the production of uniform and high-quality products.

BioPAT(R) Spectro is a product specifically developed for Quality by Design (QbD). By generating more process data using this product, the potential of Raman spectroscopy can be maximized. This enables the construction of very robust processes, resulting in the production of consistently high-quality products.

• others

Bioreactor system for cell line development and process optimization.

The Ambr1515 Generation 2 is a high-throughput "automated micro-scale bioreactor system" that reproduces the performance of laboratory-scale bioreactors. The system consists of single-use vessels, an automated workstation, and enhanced convenience software. It is designed to be installed in a standard biosafety cabinet for aseptic operations, allowing for parallel monitoring and control of 24 or 48 micro-bioreactor cultures. As the manufacturing processes for biopharmaceuticals become more complex and the density of cultures increases, scientists around the world are facing an unprecedented challenge in developing "clone, medium, and process" that meet new demands. The Ambr15 Generation 2 system enhances equipment performance that influences the success of cultures, improves flexibility, and incorporates new features that reflect user feedback. It helps address the aforementioned challenges and supports the acceleration of research by scientists.

• others

A single-use bioreactor system that dramatically enhances speed, quality, and productivity from process development to scale-up.

The "Biostat STR Series" is a single-use bioreactor system designed for rapid process development and seamless scale-up to commercial production. The newly launched third generation features a new automation platform, "BIOBRAIN," and the analytical tool "BioPAT(R)," enabling exceptional speed, quality, and productivity. Stable and predictable processes greatly contribute to providing safe and reliable biopharmaceuticals to patients worldwide, accelerating our customers' manufacturing operations and business.

• others

Seed culture for small-scale protein production.

- The BioStat RM is a single-use rocking bioreactor that is fully compliant with GMP. < BioStat RM 20 | 50 Basic > The BioStat RM 20 | 50 Basic is a standalone bioreactor that is the ideal size for benchtop use. < BioStat RM 200 > The BioStat B and RM 200 Rocker are single-use rocking bioreactors designed for large-scale applications. - The Flexsafe bags have a proven track record with a wide range of cell lines including CHO, NS0, SF9, E. coli, T cells, and mesenchymal stem cells. Using Flexsafe RM bags in the seed train allows for easy scale-up to the BioStat STR single-use bioreactor that utilizes Flexsafe STR bags. The same polyethylene film material can be used for all cell culture steps. Flexsafe RM bags can be used with rocking bioreactors from multiple manufacturers, providing excellent growth characteristics and robustness, with stable supply.

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[Instructor] Shintaro Fukasawa, President of BM Consulting Co., Ltd. Business Mathematics Educator [Key Lecture Content] There are things we somewhat think about. However, when asked for our opinions, we hesitate to speak up because we dread being questioned with "What is your basis?" This is a growing issue among business professionals. Shintaro Fukasawa, the only advocate of business mathematics in Japan and a business mathematics educator, identifies the inability of modern business people to articulate their thoughts and ideas as a "symptom." He finds commonalities between mathematical thinking and verbalization, and has developed a verbalization framework that anyone can easily practice. This content has been compiled into a book titled "How Can an Idea Become 'My Opinion'? - A Class to Turn Intuition into Logical Opinions" (2023). In this session, we will extract the essence of that book and explain how to create "logical and communicative opinions." You will take home tips that will dramatically change your business communication starting tomorrow.

[Speaker] Tokyo Electric Power Company Holdings, Inc. Area Energy Innovation Business Office Battery Business Group Manager Akira Oguri [Key Lecture Content] In a carbon-neutral society where renewable energy becomes the main power source, batteries play a crucial role in avoiding output suppression of renewable energy and providing adjustment capabilities to the power grid. Utilizing the knowledge, business experience, and engineering skills cultivated through NAS batteries and the electric power business, we will introduce our efforts to provide battery energy services that align with the actual usage of customers aiming for carbon neutrality and resilience enhancement. [Lecture Items] 1. Tokyo Electric Power Group's initiatives toward carbon neutrality 2. Current situation surrounding the battery market 3. Safety requirements for battery systems 4. Introduction of Tokyo Electric Power Group's initiatives related to batteries 5. Future business outlook 6. Q&A / Business card exchange

[Speaker] Takuya Oue, Executive Officer COO, ExaWizards Inc. Hiroaki Izuma, Advisor, Business Creation Division, Tohoku Electric Power Co., Inc. Advisor, ExaWizards Inc. [Key Lecture Content] Since the emergence of ChatGPT at the end of 2022, generative AI has rapidly permeated various aspects of society, fundamentally changing its nature. In Japan's energy industry, which is faced with the extremely challenging task of simultaneously addressing the supreme issues of decarbonization, stable supply, and economic growth, AX (AI Transformation) based on the utilization of AI plays a crucial role. This lecture will illustrate the AX in the energy sector and depict the vision for 2030 based on a wealth of examples. [Lecture Topics] 1. Structural transformation facing the energy industry 2. Energy AX from the field perspective 3. Learning from the AX strategies of major domestic players 4. Learning from advanced overseas examples 5. Vision for 2030 6. Q&A / Business card exchange

Thank you very much for your continued support. We are pleased to announce the 2024 Cutting Heat Treatment Research Conference, which will be held as follows. This year, it will be conducted online via ZOOM. <Date and Time> February 13, 2025 (Friday) Event Time: 10:00 AM - 5:00 PM (Login starts at 9:30 AM) Cutting Part: 10:00 AM - DX & Environment: 1:00 PM - Heat Treatment Part: 3:00 PM - <Registration Method> This event will be conducted by prior reservation. Participation Fee: Free Registration Deadline: February 6, 2026 (Friday) *Please check the details at the provided URL. We look forward to your participation. Thank you very much for your cooperation. ◆ Seminar Information URL https://www.idemitsu.com/jp/business/lube/news/2025/251212.pdf

We will be exhibiting at "Japan IT Week Nagoya," which will be held at Port Messe Nagoya from February 25 (Wednesday) to February 27 (Friday), 2026. Japan IT Week Nagoya is the largest comprehensive exhibition in the Chubu region related to system development, operation, and maintenance. It consists of four exhibitions. Our company will be participating in the "Embedded, Edge, and IoT Development EXPO." At our booth, we will offer free consultations on our production management cloud system, "SmartF." If you have any of the following concerns, please feel free to stop by our booth: ✅ I want to know how to digitalize the manufacturing site. ✅ I am considering implementing barcode management. ✅ I want to move away from manual management using handwritten notes or Excel. ✅ I want to streamline the management of inventory, quality, and costs. ✅ I want to know the differences from the production management system I am currently using. We can also provide proposals based on the challenges faced by attendees. If you have any issues with digitalizing your operations, please feel free to consult with us!