Analysis of multivalent aggregates of monoclonal antibodies using size exclusion UPLC.
Improvement of separation of high molecular weight proteins up to 1.8 MDa.
We will demonstrate the advancements in size exclusion separation based on UPLC using data analyzed from polymer protein complexes, comparing it with HPLC data. Additionally, we will analyze monoclonal antibodies containing multivalent aggregates by connecting ACQUITY UPLC BEH SEC columns with pore sizes of 200 Å and 450 Å, showcasing the benefits obtained. 【Application Benefits】 ○ Compared to conventional HPLC-based SEC, improved separation of high molecular weight proteins up to 1.8 MDa. ○ In the analysis of monoclonal antibody aggregates containing dimers and higher-order multimers, the separation range is expanded by connecting the BEH450 SEC column with the BEH200 SEC column. For more details, please contact us or download the catalog.
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basic information
【Waters Solutions】 ○ ACQUITY UPLC BEH450 SEC, 2.5 μm column ○ ACQUITY UPLC BEH200 SEC, 1.7 μm column ○ ACQUITY UPLC H-Class Bio system ○ BEH450 SEC protein standard mix ○ Auto•BlendTM Plus technology ○ Empower(R) 3 chromatography data software ● For more details, please contact us or download the catalog.
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For more details, please contact us or download the catalog.
Company information
Waters Corporation, headquartered in Milford, Massachusetts, USA, has played a pioneering role as a specialized manufacturer of liquid chromatography since its establishment in 1958. Actively engaged in the development of new products and technologies, it has grown into an international group company that supplies not only high-performance liquid chromatography but also mass spectrometers (MS) and thermal analysis instruments. Waters Japan started operations in 1973 (Showa 48) as the Japanese base of Waters Corporation. Inheriting the corporate ethos of the U.S. headquarters, we have made "Customer Success" our mission and continue to provide innovative technologies and lab solutions.
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