SwitchSENSE High-Sensitivity Molecular Interaction Analysis Device heliX+
heliX Biosensors
High-sensitivity biosensor based on the SwichSENSE principle using DNA as a fixation tool.
heliX/heliX+ is a high-sensitivity device for analyzing molecular interactions and protein properties that adopts a new principle called "SwitchSENSE," which uses DNA nanolevers as a immobilization tool. It has approximately 100 times the sensitivity of existing biosensors and possesses a wide range of applications and analytical capabilities, including the analysis of high-affinity interactions that are difficult to measure with conventional devices, dual specificity interaction analysis, and enzyme kinetics analysis of nucleic acid-related enzymes. Additionally, the chip can be reused multiple times. Since DNA is used for immobilization, it allows for a high degree of freedom in presenting molecules on the chip, such as immobilizing two types of molecules. There are also no effects from the immobilization matrix. Furthermore, being a sensor that uses nucleic acids allows for easy implementation of enzyme kinetics analysis for nucleic acid-related enzymes such as polymerases and endonucleases, and it demonstrates significant power in evaluating inhibitors of viral proliferation. The modular design of the device also enables easy high-throughput capabilities. It can be utilized in a wide range of research, from drug discovery to biophysical fundamental research on biomolecules.
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basic information
[Features] - A high-sensitivity sensor approximately 100 times more sensitive than conventional biosensors: Detection limit of 10 fM - Capable of detecting structural changes in proteins with high precision (±0.1 nm) - By using nucleic acids to present molecules on the chip, various molecules can be easily presented and exchanged on the chip through hybridization - The density of the molecules presented on the chip can be easily controlled. Immobilization of two types of molecules is also possible. - Compatible with 96/384 well plates. Modular design allows for high-throughput capabilities.
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P8
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Applications/Examples of results
● High-sensitivity analysis of molecular interactions High-sensitivity measurements with about 1/100 of the immobilization amount of conventional biosensors like SPR Accurately detect strong interactions with very slow dissociation! Also accurately detect very fast dissociation! ● Analysis of dual specificity interactions Accurately analyze the cooperative interactions of molecules with different targets, such as bispecific antibodies and PROTACs ● Simplified kinetics analysis of nucleic acid-related enzyme reactions (Analysis of enzyme reactions such as polymerases, ligases, helicases) ● Detection of structural changes Detection of structural changes associated with interactions (accuracy ±0.1nm) ● Compatible with 96/384 well plates Easily scalable to high throughput through modularization
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| Model number | overview |
|---|---|
| heliX | |
| heliX+ |
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Company information
DKSH is a member of the Swiss global company "DKSH Group." It provides comprehensive services and solutions across the entire value chain, combining procurement, marketing, sales, distribution, and after-sales service, through its three business divisions: consumer goods, production materials, and technology, with a long-term perspective.
