DKSH Japan Co., Ltd. will be exhibiting at BioPharma 2017.

High-sensitivity biosensor based on the SwichSENSE principle using DNA as a fixation tool.

heliX/heliX+ is a high-sensitivity device for analyzing molecular interactions and protein properties that adopts a new principle called "SwitchSENSE," which uses DNA nanolevers as a immobilization tool. It has approximately 100 times the sensitivity of existing biosensors and possesses a wide range of applications and analytical capabilities, including the analysis of high-affinity interactions that are difficult to measure with conventional devices, dual specificity interaction analysis, and enzyme kinetics analysis of nucleic acid-related enzymes. Additionally, the chip can be reused multiple times. Since DNA is used for immobilization, it allows for a high degree of freedom in presenting molecules on the chip, such as immobilizing two types of molecules. There are also no effects from the immobilization matrix. Furthermore, being a sensor that uses nucleic acids allows for easy implementation of enzyme kinetics analysis for nucleic acid-related enzymes such as polymerases and endonucleases, and it demonstrates significant power in evaluating inhibitors of viral proliferation. The modular design of the device also enables easy high-throughput capabilities. It can be utilized in a wide range of research, from drug discovery to biophysical fundamental research on biomolecules.

• Analytical Equipment and Devices

A flow imaging microscope capable of particle size distribution and particle image analysis in solution. It is used for detecting impurities in biopharmaceuticals.

Features - Measurement possible with a small sample volume (100 μL and above) - Measurable particle size: 0.3 μm to 600 μm - High-resolution image analysis through threshold optimization - Equipped with autofocus function - Capable of saving raw image (video) files - No sheath fluid required - Easy replacement of flow cell and simple cleaning - Lens interchangeable (2X, 4X, 10X, 20X) - Compatible with dedicated auto-sampler - Compliant with 21 CFR Part 11

• Other physicochemical equipment

High-precision viscosity measurement with a minimum of 10μL of micro-sample, up to 100,000 cp. Fully automated system compatible with 96-well plates. Also supports shear rate scanning.

A new ultra-micro viscometer utilizing microfluidic control and microelectromechanical systems technology. The VROC Initium is a fully automated model that handles everything from sample introduction to channel cleaning, solving the issues of traditional viscosity measurement that required cumbersome procedures and large sample volumes. It contributes to research and development and quality control across a wide range of fields, including biopharmaceuticals, biological samples, inkjet inks, various petrochemical products, and battery materials. [Features] - Fully automated system compatible with 96 wells - High precision and high reproducibility - Supports temperature and shear rate scanning - Small sample volume (10 μL and up) - Wide measurement range (0.2 to 100,000 cp) - High shear rate capability (up to 1.6 million /sec) - Accurate temperature control (4 to 70 °C) - Closed system measurement - Compatible with non-Newtonian fluids

• Composite Materials
• Viscometer
• Testing Equipment and Devices

**Exhibition Content** Streamlining Software Development in the SDV Ecosystem In this exhibition, we will introduce comprehensive solutions for the arrival of the Software Defined Vehicle (SDV) era. As the value of automobiles shifts from hardware to software, there is a growing demand for balancing development efficiency and quality. Our services, which leverage advanced technologies and know-how based on our extensive track record, will strongly support your SDV development: - SDV Total Solution: An integrated approach to optimize the entire vehicle system - SDV Safety Integration: Development processes and verification techniques compliant with functional safety standards - Streamlining Software Development with Generative AI: Code generation and test automation utilizing the latest AI technologies - Integrated Simulation Environment Construction Solutions: Building an efficient development environment by linking multiple simulation tools - Simulink Model Guideline Check Tool "Model Dr. MDiA": Automatically verifying model quality to improve development efficiency and quality

On Tuesday, April 21, at Iidabashi, paperlogic will have a booth at "Canon Selection 2026." The theme of this event is "Paper Output × Data Utilization." It is a comprehensive exhibition filled with hints to promote DX in the office and achieve operational efficiency. At the venue, there will be the latest "Security Measures Seminar" to protect companies from supply chain attacks, as well as programs like creating promotional flyers that anyone can make, "Super Easy! PDF Utilization Techniques" to alleviate daily frustrations, and "Paperless Fax Experience" to support remote work, all aimed at solving on-site challenges. From paperlogic, we will introduce the 【paperlogic Electronic Contract】 as a solution for "Document Management and Back Office Digitization." We will have actual operation demonstrations at our booth and will directly address your concerns regarding document management. We also have special plans exclusively for Otsuka Corporation, so please come and visit us.

We will be holding a technical training session for MilkoScanFT3 as detailed below. In this training, we will provide a broad range of information useful for operating the equipment, including explanations of the principles and structure of the device, how to create measurement products, daily maintenance, and responses to troubleshooting. Additionally, this year we will introduce new ways to utilize digital services (such as FossCalibrator and IQX), and we have also prepared hands-on sessions where customers can experience operating the equipment using a PC. The training content is designed to be more practical and immediately applicable in real-world settings. We understand you may be busy, but we kindly ask you to consider participating. ■ Osaka Venue: June 25-26 ■ Morioka Venue: July 8-9 ■ Tokyo Venue: August 27-28 ■ Obihiro Venue: September 17-18 ■ Fukuoka Venue: October 8-9 *Please check the PDF for more details.

■Connecting Biomarker Discovery to Clinical Application - Explained with Real Cases of Neurodegenerative Diseases Although biomarkers are discovered, many do not reach clinical application. The reasons for this lie in multiple hurdles that arise after discovery, such as "narrowing down candidates," "reproducibility," and "connecting to clinical practice." 1. How should promising candidates obtained from comprehensive exploration be narrowed down? 2. How can reproducibility and scalability be ensured? 3. What are the key points for smoothly transitioning to clinical research? 4. What should be considered in data science throughout the overall flow? In this online seminar, we will clearly explain specific strategies for advancing from discovery to clinical application based on actual research cases of Alzheimer's disease and multiple sclerosis, in an easy-to-understand manner in Japanese. *Olink products and services are for research purposes only. Please note that they cannot be used for diagnostic purposes.

[Lecturer] Shingo Horiguchi, CEO of DigitalBlast Inc. / CEO of SpaceBlast Inc. Yoshifumi Sakamoto, CTO of DigitalBlast Inc. / CTO of SpaceBlast Inc. [Key Lecture Content] Amid ongoing discussions both domestically and internationally, DigitalBlast and SpaceBlast are working towards the realization of next-generation infrastructure that processes data generated in space and delivers its value to the ground. In this lecture, we will introduce the development of high-reliability edge computing technology, based on the adoption of the JAXA Space Strategy Fund's technology development theme "On-Orbit Data Center Construction Technology," and the business concept of the "Space AI Cloud" that we aim to realize through this technology. Additionally, we will explain the worldview envisioned by the "Space AI Cloud," including communication satellites, observation satellites, space stations, lunar exploration, and their contributions to the ground.