In vivo drug imaging device (coherent Raman microscopy system)

Technical Overview This technology enables the three-dimensional imaging of the localization distribution of small molecular compounds whose properties change when labeled with fluorescent dyes, by identifying molecular structures through induced Raman scattering under a microscope. Unlike commercially available Raman microscopes, this system detects high-intensity induced Raman scattering light, which is advantageous for depth-direction tomography. To make the coherent Raman microscope operable by non-specialist users, the light source has been integrated, and it has been commercialized as an all-in-one measurement device. Highlights of the Exhibition The actual device will be used to demonstrate the measurement procedures for inhalation anesthetic molecules, steroid molecules, amino acids and amino acid derivatives, vitamins, and other samples, presented through video explanations. The panel will explain a successful case where the cornea of a mouse eye was immersed in a taurine solution, which is also included in eye drops, and the concentration distribution within the cornea was detected. Expected Applications - Non-destructive measurement of drug penetration into the skin and other tissues - Measurement of the distribution of drug molecules within cells - Tracking changes in molecular composition due to metabolism and other factors

The explanation of the device, its operation methods, and features will be provided in a video. 1. Technical Overview This technology allows for the three-dimensional imaging of the localization distribution of small molecular compounds that change their properties when labeled with fluorescent dyes, by identifying molecular structures through induced Raman scattering under a microscope. Unlike Raman microscopes that are commercially available elsewhere, this technology detects high-intensity induced Raman scattering light, which is advantageous for depth-direction tomography. To enable users who are not specialists in coherent Raman microscopy to operate it, the light source has been integrated, and it has been commercialized as an all-in-one measurement device. 2. Highlights of the Exhibition The procedures for measuring samples such as inhalation anesthetic molecules, steroid molecules, amino acids and amino acid derivatives, and vitamins using this device will be introduced with explanations in video format. The panel will explain a successful case where the cornea of a mouse eye was immersed in a taurine solution, which is also included in eye drops, and the concentration distribution within the cornea was detected. 3. Expected Applications - Non-destructive measurement of drug penetration into the skin and other tissues - Measurement of the distribution of drug molecules within cells - Tracking changes in molecular composition due to metabolism and other factors