Drug membrane permeability tests using artificial membranes without Caco-2 cells, with a unique lamination technology to create multilayers of lipids and films.
Evaluation of Drug Permeability from Cell Membranes Using Artificial Membranes In the development of new drugs, the examination of the pharmacological properties and toxicity of compounds, along with the study of absorption characteristics from intestinal membranes, is considered one of the important factors. The evaluation of absorption characteristics is generally conducted using Caco-2 cell tests. To perform Caco-2 tests, cell culture on the membrane of test well plates is required, but this cultivation demands significant time and effort. Issues may arise with the reproducibility of permeability tests due to the heterogeneity of the culture. The Permeapad Plate, which laminates phospholipids with a special film, serves as an alternative method for compounds where membrane permeability is rate-limiting in Caco-2 tests. Since the phospholipids are laminated with a film, they can be stored at room temperature and used immediately. The homogeneous film allows for high measurement reproducibility.
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basic information
Test temperature: 25℃, 37℃, etc. pH range: 1-10 Reagent concentration: e.g. 5mM Test duration: up to 24 hours Wells: 96 Material: Polystyrene (plate) Storage: Place away from direct sunlight and ultraviolet light Storage temperature: 25℃ Shelf life: 1 year
Price range
P2
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Applications/Examples of results
Membrane permeability test
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Company information
Starting as an import trading company in 1927, we have been developing our business with many overseas suppliers and domestic customers over the years. Through our services of connecting the two together, Higuchi has become the well trusted "Japan distribution channel" for suppliers, and the "dependable vendor" who provides a stable supply of the latest high-valued overseas products to customers. Today, we conduct not only importing but also exporting businesses, trilateral trades, and overseas business investments as well. We have also expanded to local subsidiaries in the United States and China, to which we are able to effectively network overseas. Higuchi believes in the criticalness of providing a stable supply to customers, and we also place the highest priority on the coexistence with suppliers, to whom we can mutually develop together in a long-term perspective. Your support and consideration to our corporate philosophy would be much appreciated.