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  6. Evolved Biochromatography Media CIM Monolith Column

Evolved Biochromatography Media CIM Monolith Column

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last updated:Oct 15, 2025

Sartorius Stedim Japan K.K.
Sartorius Stedim Japan K.K.
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Suitable for the purification and analysis of bioprocesses such as viruses, nucleic acids, and antibodies.

The CIM monolith column enables high-purity chromatography purification in 2 or 3 steps for viral vectors and nucleic acids (mRNA, pDNA, oligonucleotides) such as AAV used in cell and gene therapy, vaccine manufacturing, as well as for bio-nanoparticles like exosomes, and for the purification of peptides, proteins, and antibodies. With demonstrated scalability from 1 mL to 8000 mL, we support efforts to enhance productivity and process efficiency in biotechnology through the provision of pre-packed cGMP formats, fast run times, large capacities, and purification packages tailored to specific fields and modalities.

    Other physicochemical equipmentothers
cimmultus-group-intermediate-volumes-b-0000991-white-sartori.jpg

Evolved Biochromatography Media CIM Monolith Column

cimmultus-group-intermediate-volumes-b-0000991-white-sartori.jpg
cimmultus-group-intermediate-volumes-b-0000991-white-sartori.jpg
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basic information

CIM monolith columns and services provided by Sartorius offer suitable solutions for various challenges in chromatography during downstream processes. ● Excellent separation capability and high throughput - Achieves high flow rates of up to 16 CV/min - Supports from lab adjustments to bioproduction processes High throughput purification with high flow rates and low back pressure ● Easy handling - Pre-packed columns enclosed in disposable housings - Reusable through CIP - Fittings compatible with equipment from various manufacturers ● Validation and quality - Designed, developed, and manufactured with a QC system compliant with ISO 9001 - Monolith columns focused on biopharmaceutical purification - Materials certified to USP Class VI

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catalog(16)

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CIMac analysis column

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Purification of AAV empty/full: Chromatographic separation of adeno-associated virus particles (empty/full) using a CIM monolith.

Purification of AAV empty/full: Chromatographic separation of adeno-associated virus particles (empty/full) using a CIM monolith.

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Purification of AAV empty/full: Chromatographic separation of AAV8 capsid empty/full.

Purification of AAV empty/full: Chromatographic separation of AAV8 capsid empty/full.

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Purification of messenger RNA using affinity chromatography with CIMmultus Oligo dT columns.

Purification of messenger RNA using affinity chromatography with CIMmultus Oligo dT columns.

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Purification of Messenger RNA: Analysis of mRNA Purity Using CIMac PrimaS

Purification of Messenger RNA: Analysis of mRNA Purity Using CIMac PrimaS

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Purification of messenger RNA: mRNA purification using CIMmultus C4 HLD.

Purification of messenger RNA: mRNA purification using CIMmultus C4 HLD.

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Purification of Plasmid DNA: Improving the productivity of pDNA downstream processes through sample replacement chromatography.

Purification of Plasmid DNA: Improving the productivity of pDNA downstream processes through sample replacement chromatography.

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Purification of Plasmid DNA: A new purification process for plasmid DNA (pDNA) from lab to production scale.

Purification of Plasmid DNA: A new purification process for plasmid DNA (pDNA) from lab to production scale.

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Purification of Plasmid DNA: Optimization of CIMac pDNA-0.3 Analysis Column - Reproducibility of Chromatography

Purification of Plasmid DNA: Optimization of CIMac pDNA-0.3 Analysis Column - Reproducibility of Chromatography

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Purification of Plasmid DNA: CIMmultus HiP2 Plasmid Process Pack

Purification of Plasmid DNA: CIMmultus HiP2 Plasmid Process Pack

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Purification of Exosomes: Development of a Separation Method for Exosomes Using Large Pore Size Monolithic Support

Purification of Exosomes: Development of a Separation Method for Exosomes Using Large Pore Size Monolithic Support

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Purification of Exosomes: Purification of Exosomes using CIMmultusTM EV-1 Advanced Composite Column

Purification of Exosomes: Purification of Exosomes using CIMmultusTM EV-1 Advanced Composite Column

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Purification of Exosomes: Process Monitoring Using Immunofluorescence and Multi-Angle Light Scattering Detector - Tracking Extracellular Vesicles in Analytical HPLC

Purification of Exosomes: Process Monitoring Using Immunofluorescence and Multi-Angle Light Scattering Detector - Tracking Extracellular Vesicles in Analytical HPLC

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PATfix pDNA platform

PATfix pDNA platform

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[Sending Recorded Video] Cutting-edge pDNA and AAV Therapeutics: Next-Generation Purification Technology Utilizing Monoliths

  • Seminar・Event

Participation in this webinar has ended. If you wish to view it, please contact us. We will send you the URL for the recorded video at a later date. AAV-based gene therapy is widely accepted and recognized in the biopharmaceutical industry. However, there are still challenges to address in order to manufacture affordable and safe AAV-based products with robust purification processes that are easy to scale up in downstream process development. In this webinar, we will explain how Sartorius can assist you in developing scalable and robust downstream purification processes for AAV using the Monolith provided by Sartorius. AAV Webinar Series 1 is here: https://srtrs.info/ios9v *We apologize, but participation from companies in the same industry and from email addresses other than those of your organization is not permitted. Thank you for your understanding.

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[Sending recorded video] Cutting-edge mRNA therapeutics - Next-generation purification technology utilizing Monoliths

  • Seminar・Event

Participation in this webinar has ended. If you wish to view it, please contact us. We will send you the URL for the recorded video at a later date. During the COVID-19 pandemic, mRNA-based vaccines have been widely recognized by the biopharmaceutical industry and regulatory authorities. However, in downstream process development, there are challenges to address in order to manufacture affordable and safe mRNA-based vaccines using scalable and robust purification processes. We aim to introduce solutions that can be provided using our CIM monolith and develop a scalable and robust downstream purification process from pDNA to mRNA. ▪ Method of holding: Webinar recorded broadcast [in Japanese, free of charge] *We sincerely apologize, but participation from individuals using email addresses other than those from your company or organization is not permitted. Thank you for your understanding.

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[We will send a recorded video] Solutions for mRNA pharmaceutical manufacturing proposed by Sartorius (from process development to production)

  • Seminar・Event

Participation in this webinar has ended. If you wish to view it, please contact us, and we will send you the URL for the recorded video at a later date. In recent years, the rapid spread of mRNA vaccines has suddenly drawn attention to this field, but it seems that a standardized platform has yet to be established. In this webinar, we will particularly address two key points—IVT and purification—through our company's new solution-based approach. 【Main Learning Content】 ▪ Current status and challenges of mRNA pharmaceutical manufacturing processes ▪ Revolutionary purification column (Monolith) ▪ Diverse process development approaches *We kindly ask that inquiries be made using email addresses from your company or organization, as we regretfully cannot accommodate inquiries from other email addresses. Thank you for your understanding.

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[On-Demand Streaming Available] September 28 (Tuesday) Overseas Webinar 'Simplifying the mRNA Process_Part 1: Improving pDNA Purity and Yield'

  • Seminar・Event

Participation in this webinar has ended. Those who wish to view it on demand can register through the details and application section. mRNA vaccines play a crucial role in combating SARS-CoV-2, and the need to produce mRNA has never been greater due to the ongoing development of treatments for various indications. In this three-part webinar series, Sartorius experts will explain how improvements in processes, analytics, and tools are key to meeting demand. Part 1 will explore the processes, analytics, and tools needed to meet the high demand for mRNA, starting with the production of pDNA. We will introduce methods to achieve high yields of pDNA by ensuring the quality and purity of raw materials and optimizing the manufacturing process. [Topics] ▪ Examination of strategies to minimize contamination from product-derived impurities in IVT reactions ▪ Introduction of ready-to-use solutions for scalable pDNA chromatography purification ▪ Verification of the actual effectiveness of the HiP2 Plasmid Process Pack for purifying linearized pDNA

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Sartorius

Sartorius Stedim Japan K.K.

Pharmaceuticals and Biotechnology

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Sartorius Stedim, established in 2007 through the merger of the German company Sartorius, founded in 1870, and the French company Stedim, is a pioneer in "Single-Use Technology (SUT)." As a company capable of providing comprehensive technical support to the pharmaceutical and biotechnology industries, its cutting-edge technology is highly regarded worldwide in the fields of scientific instruments and biotechnology.

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