To facilitate the rapid and easy removal of enzymes, we offer a wide range of products that immobilize enzymes in spin columns.
Genovis provides rapid and user-friendly proprietary enzyme tools primarily for the biopharmaceutical industry. These tools, available worldwide, are called SmartEnzymes and are highly useful for the following applications: ● Analysis and characterization of antibody drugs and antibody-drug conjugates (ADCs) ● Conversion of antibody glycosylation ● Automation of antibody subunit analysis ● Antibody modification (fluorescent labeling, biotinylation, azidation, etc.) ● Research and development of antibody-drug conjugates (ADCs) ● De-fucosylation of glycoproteins ● Removal of glycans from proteins You can check the features and usage examples of various enzymes by downloading the PDF. Please feel free to take a look.
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basic information
<Antibody-related Products> FabRICATOR (IdeS) - Cleaves just below the IgG hinge region FabALACTICA (IgdE) - Cleaves above the human IgG1 hinge region FabRICATOR Z (IdeZ) - Cleaves just below the mouse IgG hinge region FabULOUS (SpeB) - Cleaves above the IgG1 hinge region GingisKHAN (Kgp) - Cleaves above the human IgG1 hinge region GlycINATOR (EndoS2) - Hydrolyzes the glycan in the IgG Fc region IgGZERO (EndoS2) - Hydrolyzes the complex-type glycan in the Fc region GlyCLICK - Site-specific modification of native IgG TransGLYCIT - Transglycosylation of IgG <Saccharide Analysis Related> PNGase F - Hydrolyzes N-linked glycans OpeRATOR - Specifically cleaves proteins with O-linked glycans OglyZOR - Hydrolyzes core-1 O-linked glycans SialEXO - Hydrolyzes sialic acid FucosEXO - Hydrolyzes α1-2,3,4-linked fucose GalactEXO - Hydrolyzes β1-3,4-linked galactose
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Applications/Examples of results
<Antibody-related Products> Generation of antibody fragments Characterization of antibody-drug conjugates (ADCs) Automation of antibody subunit analysis Deglycosylation of antibodies Antibody modifications (fluorescent labeling, biotinylation, azidation, etc.) Conversion of glycan structures in IgG antibodies Production of antibody-drug conjugates (ADCs) <Glycan Analysis Related> Glycan profiling Removal of glycans from proteins Defucosylation of glycoproteins Mapping of O-linked glycans
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Rohmatsu Trading Co., Ltd. engages in the procurement, research, and contracting of overseas chemical products, as well as providing information on them. From the top management to all employees, we unite as one, always keeping five keywords in mind, continuously striving for creativity and ingenuity, and serving the market to contribute to society.