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  6. RheaVita Corporation RheaLyo Mono System

RheaVita Corporation RheaLyo Mono System

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RheaLyo Mono for R&D use

last updated:May 12, 2025

ライフィクスアナリティカル
ライフィクスアナリティカル
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Reduction of time/cost in process development and improvement of quality in freeze-drying of biopharmaceuticals.

The "RheaLyo Mono Single Vial Unit" is a freeze-drying device specifically designed for research and development, based on continuous freeze-drying technology. It is well-suited for very rapid formulation, process development, and optimization with minimal material consumption. From vial-level to continuous freeze-drying production lines (GMP Flex), it enables quick and easy process development and production scale-up based on numbering up. 【Features】 ■ Spin freeze vials that allow precise control of cooling rates ■ Control of primary freezing and secondary drying using infrared ■ Rapid freeze-drying is possible due to the thin product layer and large surface area ■ Complete monitoring, control, and inspection of vials ■ Reduction of quality variation for each vial *At the 2024 CPHI, RheaVita's GMP-Flex continuous freeze-drying system received the "Manufacturing Excellence" award! *For more details, please refer to the PDF document or feel free to contact us.

    Drying EquipmentOther process controls
rheavitaDSCF9915e-2025x2048

RheaVita Corporation RheaLyo Mono System

rheavitaDSCF9915e-2025x2048 System aith Scientist.png
rheavitaDSCF9915e-2025x2048 System aith Scientist.png Vial pic.jpeg RheaLyo TM.jpeg
  • https://rheavita.com/
  • Special site - Product/service details - https://pr.mono.ipros.com/reifycsant/product/

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【Other Features】 - Stable quality from preclinical trials to production during scale-up - Proven processes based on validated mechanical models and digital twin model-based design - Flexibility/production efficiency: short CIP/SIP times, flexible production volumes and capacities - Reduction of ecological footprint and operational costs (over 50%) *For more details, please refer to the PDF document or feel free to contact us.

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Detailed information

  • rheavitaGMP-

    The first continuous freeze-drying system that enables GMP production. RheaVita offers a custom-designed continuous freeze-drying line compliant with GMP standards.

catalog(10)

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Automatic visual inspection of freeze-dried preparations

Automatic visual inspection of freeze-dried preparations

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Spin freeze-drying of attenuated viruses

Spin freeze-drying of attenuated viruses

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Freeze-drying lipid nanoparticles (LNP)

Freeze-drying lipid nanoparticles (LNP)

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BSL-2 Compatible Spin Freeze Drying RheaLyo Mono - RheaVita Corporation

BSL-2 Compatible Spin Freeze Drying RheaLyo Mono - RheaVita Corporation

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Information about the partnership between IMA Life and RheaVita.

Information about the partnership between IMA Life and RheaVita.

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RheaVita Single Vial Unit (SVU)

RheaVita Single Vial Unit (SVU)

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RheaVita (Reobita) Demonstration Experiment Flyer

RheaVita (Reobita) Demonstration Experiment Flyer

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Technical Information: How Continuous Freeze-Drying Fits into the Paradigm Shift from Batch Manufacturing to Continuous Production.

Technical Information: How Continuous Freeze-Drying Fits into the Paradigm Shift from Batch Manufacturing to Continuous Production.

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White Paper - Stabilization of mRNA LNPs through Continuous Freeze-Drying RheaVita

White Paper - Stabilization of mRNA LNPs through Continuous Freeze-Drying RheaVita

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The world's first GMP-compliant continuous freeze dryer has finally arrived! RheaVita.

The world's first GMP-compliant continuous freeze dryer has finally arrived! RheaVita.

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News about this product(7)

ISLFD

Notice of Participation in ISLFD - RheaVita Corporation

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From March 24 (Tuesday) to March 27 (Friday), 2026, RheaVita will exhibit as a conference sponsor at ISLFD, held in Fukuoka, in collaboration with Lifix Analytical. ISLFD is an international conference where researchers and engineers involved in freeze-drying and related technologies gather from around the world to exchange information and discuss research results and technological trends. Through our sponsorship at this conference, RheaVita will present the latest information on spin freeze-drying technology. At our booth, in addition to introducing the latest information about spin freeze-dryers, we will be open to consultations on a wide range of topics, including research and development, feasibility testing, scaling up, and comparisons with existing processes. We aim to create a valuable platform for information exchange for those asking questions such as "What is spin freeze-drying?", "What are the differences from conventional freeze-drying processes?", "What are the challenges of scaling up and reproducibility?", and "What new formulation and manufacturing approaches should be considered?". Additionally, individual meetings will be possible during the conference. If you contact us in advance, we will secure a meeting opportunity at a time that is convenient for you. Please be sure to stop by the RheaVita booth.

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RheaVita_Certificate

RheaVita has been selected as the top pharmaceutical freeze-drying solution company in Europe for 2025!

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Award to RheaVita by Pharma Tech Outlook This award is backed by numerous recommendations from many readers of Pharma Tech Outlook and is a testament to the strong trust and high evaluation RheaVita has received from customers and industry stakeholders. As a result of a rigorous review by top executives, industry experts, and the editorial board, RheaVita has been selected as the "Top Pharmaceutical Freeze Drying Solution in Europe 2025."

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Monitoring and Control of Product Temperature Using Thermal Imaging During Continuous Freeze-Drying Process of Unit Dose Formulations - Aug 2019

  • Other・notification

In recent years, the pharmaceutical industry has rapidly advanced the development of biopharmaceuticals such as therapeutic proteins and vaccines. These drugs face challenges regarding stability in aqueous solution, which is why freeze-drying has become an essential technology for long-term storage. Traditional freeze-drying is conducted in a batch process that handles multiple vials at once, resulting in long processing times and high costs. Furthermore, controlling the freezing process is difficult, leading to variations in ice crystal size among vials, which causes inconsistencies in drying rates and poses challenges for ensuring product quality uniformity. Additionally, the heat distribution within the drying chamber is uneven, raising concerns about the risk of product collapse and quality variability. To address these issues, a new manufacturing technology called "continuous freeze-drying" has emerged in recent years. This technology combines continuous supply of raw materials with continuous discharge of products, achieving shorter processing times, cost reductions, and smaller equipment. Moreover, it reduces quality differences between vials, allowing for the efficient production of uniform and stable products. This groundbreaking technology has been further commercialized by RheaVita since its introduction in 2019, and in March 2025, a GMP-compliant system was implemented at their headquarters in Belgium.

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The 41st Annual Meeting of the Japanese DDS Society

We will exhibit at the 41st Annual Meeting of the Japanese DDS Society and the accompanying exhibition.

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We will be exhibiting at the "41st Annual Meeting of the Japanese DDS Society" (at Makuhari Messe International Conference Hall) to be held from June 17 to 18, 2025, with a panel display by RheaVita. RheaVita is a pioneer in continuous freeze-drying technology, providing innovative solutions for formulation development and manufacturing processes. In this exhibition, we will introduce the company's technology through a panel display. The installation of the "GMP-Flex" continuous freeze-drying system, compliant with GMP (Good Manufacturing Practice) standards, has been completed at our headquarters in Belgium, enabling its application in actual formulation development and commercial manufacturing. We warmly invite you to visit our booth during the event. We look forward to seeing you there.

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ライフィクスアナリティカル

ライフィクスアナリティカル

Pharmaceuticals and Biotechnology

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Raifiks Analytical Co., Ltd. conducts sales activities nationwide, primarily focusing on pharmaceutical companies. Therefore, we can propose products that align with the latest model information and trends. We offer suggestions for equipment suited to each department, from the drug discovery phase, where unique medications not available from other companies are developed, to production and manufacturing. Our network extends overseas, allowing us to propose products not available through Japanese distributors and to suggest the development of products that do not currently exist in the market. We will provide solutions tailored to our customers' needs.

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