4Cell CHO Platform

"Next-Generation CHO Cell Line Development Service Integrating AI and Process Intensification - Innovation of Sartorius CLD Workflow" In biopharmaceutical development, establishing high-quality cell lines in a short period has become increasingly important. Sartorius's Cell Line Development (CLD) service has supported the approval of 7 antibody products and over 80 clinical projects to date. Seminar Points: ■ The latest workflow that selects optimal clones by AI analysis of nano-well images and fluorescence data immediately after single-cell cloning with CellCelector ■ A series of CLD processes that continue from Clone Evaluation, quality analysis, scale-up, to technology transfer to CDMO ■ Process Intensification strategies based on High Inoculation Fed-Batch and Perfusion culture ■ Media optimization service that can be used independently (supporting non-GMP prototypes to GMP manufacturing scale) Date and Time: December 3 (Wednesday) 12:20–13:20 Venue: Omiya Sonic City, Exhibition Hall 2

We will be exhibiting and presenting a luncheon seminar at BioJapan 2025, which will be held at Pacifico Yokohama from October 8 to 10, 2025. At our booth, we will introduce our cell line development services and media optimization services that achieve a scalable fed-batch process with a monoclonal antibody titer of up to 10 g/L in just 9 weeks, from DNA to RCB. We will also showcase single-use culture vessels for process development. In addition, during the luncheon seminar, we will provide a clear overview of Sartorius' CLD services, making it easy to understand for those who are new to the topic. If you are considering shortening timelines, optimizing product quality, or exploring flexible development strategies, please join us. We look forward to seeing you there. Event Overview: October 8 (Wed) - 10 (Fri), 2025, Pacifico Yokohama Exhibition Booth: Small Booth Number D-109 Luncheon Seminar: Title: Minimizing Risks in CHO Cell Line Development through Automation and Predictive Models Seminar Date and Time: October 9 (Thu) 11:30 AM - 12:30 PM

Participation in this webinar has ended. If you wish to view it, please contact us. We will send you the URL for the recorded video at a later date. Sartorius has developed CHO cell lines for over 300 projects, with 7 projects approved and more than 80 in clinical trials. The projects include IgG1, 2, 4, multi-specific antibodies, Fc fusion proteins, enzymes, hormones, new drugs, and biosimilars. Our customers range from large companies to startups, with over 70% of them being repeat clients. In this webinar, we will introduce the details of our flexible and comprehensive services, including CHO cell line development, MCB/WCB manufacturing and testing, molecular characterization, FUT8 Knock Out, provision of optimized media, and process enhancement. *We sincerely apologize, but we kindly ask that participants refrain from joining with email addresses other than those from your company or organization. Thank you for your understanding.

This event has ended. We will be exhibiting and presenting at BioProcess International Asia 2024, which will be held in Kyoto from October 21 to 23, 2024. We will introduce Sartorius's cell line development solutions that comprehensively support the commercialization of biopharmaceuticals through products, services, experience, and expertise. 【Event Overview】 Date: October 21 (Monday) 9:00 AM - October 23 (Wednesday) 5:30 PM Location: The Westin Miyako Kyoto *Pre-registration required 【Our Seminar】 Title: Fit for Future: Advancing Bioprocess Manufacturing by Identifying Top Performing Clones and Enhancing Productivity through Process Intensification Seminar Date: October 22 (Tuesday) 9:30 AM