Gene transfer with low toxicity and high efficiency
Calcium phosphate, which has long been used as a vector to transfer genes into cells, is easy to prepare and has a good shelf life, but has a problem of low gene transfer efficiency. On the other hand, it has recently been reported that gene transfer efficiency is improved by modifying oligoarginine in the vector. In the gene transfer using calcium phosphate vector modified with oligoarginine, we found that the gene transfer efficiency was improved by pre-treating target cells with a potassium-sparing diuretic. ・The present invention is cheaper and simpler than gene transfer methods such as lipofection, electroporation, microinjection, and viral vectors. ・It is less cytotoxic than non-viral gene transfer agents. ・Treatment of target cells with potassium-sparing diuretics improved gene transfer efficiency up to 10 fold.
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The revenue generated from technology transfer is reinvested as new research funding for universities and researchers, and is utilized to create further research outcomes. To ensure the smooth operation of this cycle, known as the "Intellectual Creation Cycle," we will vigorously promote technology transfer. The types of seeds we handle include patents, know-how, databases, and programs. We have established a collaborative framework by signing basic technology transfer agreements with the following universities (as of June 1, 2025): Tohoku University, Hirosaki University, Iwate University, Akita University, Fukushima University, Yamagata University, Tohoku Gakuin University, Iwate Medical University, Fukushima Medical University, Aizu University, Miyagi University, Hokkaido University, Muroran Institute of Technology, and Showa Medical University.
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