To prevent and control of the progression of bone resorption with food
Rheumatoid arthritis and periodontal disease are known to cause bone resorption due to inflammation. Although various drugs have been administered, it is desirable to inhibit and prevent bone resorption through food intake, which is easier and more convenient. In this invention, we found that two-step fermented rice bran (FRB) inhibits the formation of osteoclasts caused by inflammation and suppresses bone resorption. Furthermore, the mechanism of the suppression was confirmed, and the route to directly and indirectly suppress the formation of osteoclasts was elucidated.
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The revenue generated from technology transfer is reinvested as new research funding for universities and researchers, and is utilized to create further research outcomes. To ensure the smooth operation of this cycle, known as the "Intellectual Creation Cycle," we will vigorously promote technology transfer. The types of seeds we handle include patents, know-how, databases, and programs. We have established a collaborative framework by signing basic technology transfer agreements with the following universities (as of June 1, 2025): Tohoku University, Hirosaki University, Iwate University, Akita University, Fukushima University, Yamagata University, Tohoku Gakuin University, Iwate Medical University, Fukushima Medical University, Aizu University, Miyagi University, Hokkaido University, Muroran Institute of Technology, and Showa Medical University.
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