A patented technology that simultaneously tests both the drug release rate and permeability in a single tablet test, supporting formulation development by ranking formulations for research purposes.
DissofluxTM is a patented technology that enables simultaneous testing of both drug dissolution rates and permeability in formulations. This has the potential to function as an important research and development tool, aiding in the ranking of formulations for development. It allows for the investigation of the effects of various excipients on drug dissolution and permeability. Based on Flux values, correlations can be drawn between in vitro and in vivo results.
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basic information
This is a groundbreaking device that allows for simultaneous testing of absorption in the gastrointestinal tract layer in vivo by attaching a special apparatus to the dissolution tester.
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Applications/Examples of results
Influence of Excipients ● The differences in excipients between the test product and the standard product need to be evaluated for their potential impact on in vivo absorption. ● Common excipients known to affect absorption include: - Sugars - Alcohols = Mannitol and Sorbitol - Surfactants = Sodium Lauryl Sulfate ● Caco-2 cell-based assays are time-consuming and expensive, and there are limitations for formulations containing surfactants. ● Dissoflux can be used to understand the drug excipient-based effects on both dissolution and permeability.
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Company information
Aivic Research was established with the aim of contributing to the improvement of healthcare by helping to enhance the data accuracy of dissolution testing through the provision of excellent dissolution testers and dissolution tester inspection services, as well as introducing the latest dissolution testing information by utilizing various pipes from overseas, thereby supporting the development of the pharmaceutical industry in Japan.