Tohoku Univ. Technology : Fermentation of fully-dispersed filamentous fungi mutant : T16-155
Capable of several-fold production of the desired product!
Filamentous fungi (e.g. Aspergillus oryzae) are well-used for production of useful proteins and small molecules in industry. However, it is well-known that hyphal aggregation during the liquid cultivation often prevents from growing with high density, resulting in low productivity. This invention discloses a mutant fungus, in which α-1,3-glucan synthase (AGS) genes plus the genes on galactosaminogalactan (GAG) cluster are deficient. AGS deficient fungi (AGΔ) showed a highly dispersed property [1]. By inducing further deficiency in genes on GAG cluster, the mutant (AGΔ-GAGΔ) shows a fully dispersed state in liquid culture. Further, this phenotype contributes to well aerobic conditions during cultivation, resulting in increasing growth of cells and substance production thereby.
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The revenue generated from technology transfer is reinvested as new research funding for universities and researchers, and is utilized to create further research outcomes. To ensure the smooth operation of this cycle, known as the "Intellectual Creation Cycle," we will vigorously promote technology transfer. The types of seeds we handle include patents, know-how, databases, and programs. We have established a collaborative framework by signing basic technology transfer agreements with the following universities (as of June 1, 2025): Tohoku University, Hirosaki University, Iwate University, Akita University, Fukushima University, Yamagata University, Tohoku Gakuin University, Iwate Medical University, Fukushima Medical University, Aizu University, Miyagi University, Hokkaido University, Muroran Institute of Technology, and Showa Medical University.
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