Tohoku Univ. Technology : Strong promoter for marine invertebrates : T22-084
OsHV-1 promoter for gene delivery and a variety of applications in bivalve molluscs.
Understanding gene functions in marine invertebrates has been limited, largely due to the lack of suitable assay systems. The inventors discovered a strong viral promoter derived from a bivalve-infectious virus, ostreid herpesvirus-1 (OsHV-1). This promoter showed 24.7-fold and 16.1-fold higher activity than the cytomegalovirus immediate early (CMV IE) promoter and the endogenous EF1α promoter, the two most commonly used promoters in bivalves so far (Fig.1). GFP assays showed that the OsHV-1 promoter is active not only in scallop cells (Fig.2) but also in HEK293 cells (Fig.3) and zebrafish embryos.
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The revenue generated from technology transfer is reinvested as new research funding for universities and researchers, and is utilized to create further research outcomes. To ensure the smooth operation of this cycle, known as the "Intellectual Creation Cycle," we will vigorously promote technology transfer. The types of seeds we handle include patents, know-how, databases, and programs. We have established a collaborative framework by signing basic technology transfer agreements with the following universities (as of June 1, 2025): Tohoku University, Hirosaki University, Iwate University, Akita University, Fukushima University, Yamagata University, Tohoku Gakuin University, Iwate Medical University, Fukushima Medical University, Aizu University, Miyagi University, Hokkaido University, Muroran Institute of Technology, and Showa Medical University.







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