Tohoku University Technology: Diagnostic marker for inflammatory bowel disease: T19-072
Anti-vascular endothelial antibody (serum marker) detected in ulcerative colitis
Inflammatory bowel disease (IBD) is a general term for disease in which inflammation occurs in the colon, such as ulcerative colitis. The number of patients with ulcerative colitis is said to be 170,000 in Japan. Ulcerative colitis is an intestinal canal chronic inflammation that occurs in a relatively young aged people and it is an intractable disease with repeated recurrence and remission. The ulcerative colitis diagnosis is made through inflammatory findings and endoscopy. The presence of autoantibody such as anti-neutrophil cytoplasmic antibody and anti-smooth muscle cell antibody has been reported in ulcerative colitis, but the positivity rate is low with less than 50%. This invention is about a new marker with a positive rate of nearly 70% in patient with ulcerative colitis: anti-endothelial cell protein C receptor antibody (anti-EPCR antibody). This invention could be a new diagnostic marker for ulcerative colitis.
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The revenue generated from technology transfer is reinvested as new research funding for universities and researchers, and is utilized to create further research outcomes. To ensure the smooth operation of this cycle, known as the "Intellectual Creation Cycle," we will vigorously promote technology transfer. The types of seeds we handle include patents, know-how, databases, and programs. We have established a collaborative framework by signing basic technology transfer agreements with the following universities (as of June 1, 2025): Tohoku University, Hirosaki University, Iwate University, Akita University, Fukushima University, Yamagata University, Tohoku Gakuin University, Iwate Medical University, Fukushima Medical University, Aizu University, Miyagi University, Hokkaido University, Muroran Institute of Technology, and Showa Medical University.
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