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  6. Endotoxin measurement Sievers Eclipse

Endotoxin measurement Sievers Eclipse

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Sievers Eclipse

last updated:May 26, 2025

セントラル科学
セントラル科学
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Endotoxin measurement is semi-automated! It significantly reduces the test error rate!

The endotoxin measurement device Eclipse, developed by Sievers, aims to make endotoxin testing easy for anyone. Many users have experienced challenges with traditional endotoxin measurements, such as the time and effort required for pipetting operations and the occurrence of human errors. Eclipse has achieved semi-automation of endotoxin measurement by developing a dedicated microplate and microfluidic technology. For measuring 21 samples, pipetting operations are reduced to fewer than 30 times, and since the standard samples are pre-filled, the preparation time and effort for testing are significantly reduced. Additionally, the amount of lysate reagent used is reduced by 90% to just 1mL, contributing to the ecological protection of horseshoe crabs. The IQ/OQ can also be completed in just a few days, so you can rest assured.

    Testing Equipment and Devices
Eclipse_2.jpg

Endotoxin measurement Sievers Eclipse

Eclipse_2.jpg
Eclipse_2.jpg
  • Related Link - https://aqua-ckc.jp/topic/eclipse
  • Special site - Product/service details - https://pr.mono.ipros.com/aqua-ckc/product/

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basic information

Measurement principle: Kinetic colorimetric method/turbidity method Detection method: Absorbance Measurement range: 0.005 to 50 EU/mL Reproducibility: CV within 15% Analysis time: Up to 2 hours Sample temperature: 37±1℃ Number of samples: Up to 21 samples

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Applications/Examples of results

Endotoxin measurement of pharmaceutical water, raw materials, final products, and in-process products.

Detailed information

  • Veolia-Buyers-Guide-640x352.png

    Main body. An example of pipetting operation.

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    Main body. Microplate mounting image.

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Model number overview
SPRD85000-01 Sievers Endotoxin Analyzer Eclipse

catalog(21)

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Sievers Endotoxin Measurement Eclipse

Sievers Endotoxin Measurement Eclipse

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Validation Overview of Sievers Eclipse - PYROSTAR ES-F Turbidity Measurement Reagent

Validation Overview of Sievers Eclipse - PYROSTAR ES-F Turbidity Measurement Reagent

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Determination of equivalent onset optical density (OD) values in the Sievers Eclipse endotoxin assay.

Determination of equivalent onset optical density (OD) values in the Sievers Eclipse endotoxin assay.

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Validation Overview of Sievers Eclipse - Endochrome-LAL Reagent

Validation Overview of Sievers Eclipse - Endochrome-LAL Reagent

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Guidance on Endotoxin Testing Methods or Changes in Reagent Vendors for BLA Applications

Guidance on Endotoxin Testing Methods or Changes in Reagent Vendors for BLA Applications

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Sample storage period and summary test: How to maximize the testing efficiency of endotoxins.

Sample storage period and summary test: How to maximize the testing efficiency of endotoxins.

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Validation Overview of Sievers Eclipse - Chromo-LAL Reagent

Validation Overview of Sievers Eclipse - Chromo-LAL Reagent

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Evaluation of the storage of lysate reagents using the Endotoxin Test Sievers Eclipse.

Evaluation of the storage of lysate reagents using the Endotoxin Test Sievers Eclipse.

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Validation Overview of Sievers Eclipse_Bioendo-TAL Reagent

Validation Overview of Sievers Eclipse_Bioendo-TAL Reagent

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Validation Overview of Sievers Eclipse_PYROSTAR ES-F Turbidity Method Reagent

Validation Overview of Sievers Eclipse_PYROSTAR ES-F Turbidity Method Reagent

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Comparison of Setup Time and Measurement Results: Eclipse vs 96-Well Microplate

Comparison of Setup Time and Measurement Results: Eclipse vs 96-Well Microplate

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Reduction of the amount of lysate reagent used in endotoxin assays compliant with the pharmacopoeia.

Reduction of the amount of lysate reagent used in endotoxin assays compliant with the pharmacopoeia.

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Overview of ANSI AAMI ST72:2019 and Sievers Eclipse

Overview of ANSI AAMI ST72:2019 and Sievers Eclipse

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Endotoxin analysis using genetically modified reagents

Endotoxin analysis using genetically modified reagents

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Endotoxin measurement Sievers Eclipse compliance with 21 CFR Part 11

Endotoxin measurement Sievers Eclipse compliance with 21 CFR Part 11

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Selection of experimental equipment for endotoxin testing

Selection of experimental equipment for endotoxin testing

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Quality of Sievers Eclipse Microplate

Quality of Sievers Eclipse Microplate

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Endotoxin Measurement Sievers Eclipse Buyer's Guide

Endotoxin Measurement Sievers Eclipse Buyer's Guide

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Seven Reasons to Switch to the Sievers Eclipse Simple Endotoxin Testing Method

Seven Reasons to Switch to the Sievers Eclipse Simple Endotoxin Testing Method

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What is an endotoxin test using microfluidic technology?

What is an endotoxin test using microfluidic technology?

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Three ways to simplify endotoxin automated testing.

Three ways to simplify endotoxin automated testing.

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News about this product(2)

Notice of Participation in the 27th Interphex Week Tokyo from July 9 (Wednesday) to July 11 (Friday), 2025

  • Seminar・Event

Central Science Co., Ltd. will be exhibiting in the Process Inspection and Measurement Zone at the "27th Interphex Week Tokyo" held at Tokyo Big Sight. At our booth, we will focus on products under the Sievers brand, showcasing measuring instruments used for pharmaceutical water management. - Products to be displayed: "Online TOC Analyzer Sievers M500" "Laboratory TOC Analyzer Sievers M9" "Endotoxin Analyzer Sievers Eclipse" "Bio-Burden Rapid Analysis Device Sievers Soleil," among others. Additionally, we plan to hold a seminar at the exhibitor seminar venue on the theme "How to streamline manufacturing processes while ensuring the quality of pharmaceutical water?" We sincerely look forward to your visit.

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[Notice of Exhibition Participation] Announcement of Participation in CPHI Japan 2026

  • Seminar・Event

~Exhibiting measurement instruments for pharmaceutical water management centered around Sievers brand products~ Central Science Co., Ltd. will exhibit at "CPhI Japan 2026 (International Pharmaceutical Development Exhibition)" held at Tokyo Big Sight from April 21 (Tuesday) to April 23 (Thursday), 2026. At this exhibition, we will focus on products from the Sievers brand and introduce various measurement instruments used for pharmaceutical water management and cleaning validation. Through the display of actual devices, you can confirm the features of the measurements and the operational image. - Main exhibited products Sievers TOC Analyzer M9 Sievers Online TOC Analyzer M500 Sievers BioBurden Rapid Measurement Device Soleil Sievers Endotoxin Analyzer Eclipse If you are interested in improving the efficiency of water quality management and quality assurance operations in the pharmaceutical and biotech fields, please stop by our booth.

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セントラル科学

セントラル科学

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Since our establishment in 1967, we have been dedicated to the development and dissemination of water quality measurement devices that anyone can use quickly, easily, and with high precision. In today's world, where the effective use of water, a limited resource, is required alongside environmental conservation, we aim to be a total solution provider that responds to all water environments by utilizing our water quality measurement devices, technology, and services. Furthermore, leveraging the latest technology and years of know-how, we are committed to delivering user-friendly and reliable water quality measurement devices more affordably, quickly, and widely.

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